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Smallpox made its first appearance at least as early as 10,000 B.C., but it wasn't until 1977 when the deadly disease that killed as many as a third of its victims was eradicated worldwide. We owe its total disappearance to the first successful vaccine. Implementing this successful device was, however, not without great struggle. In the nineteenth century United States, Great Britain, and other countries, enforcement of compulsory vaccination laws were met with legal appeals, resistance and sometimes violence. Michael Willrich's Pox returns us to Progressive era antivaccination movements that will remind many contemporary readers of much more recent events.