Practical Bioinformatics / Edition 1

Practical Bioinformatics / Edition 1

by Janusz M. Bujnicki
     
 

ISBN-10: 3540742670

ISBN-13: 9783540742678

Pub. Date: 10/28/2007

Publisher: Springer Berlin Heidelberg

The book is unique in that it bridges the gap between bioinformaticists and molecular biologists, i.e. the developers and the users of computational methods for biological data analysis and in that it presents examples of practical applications of the bioinformatics tools in the "daily practice" of an experimental research scientist.

The book starts with reviews on

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Overview

The book is unique in that it bridges the gap between bioinformaticists and molecular biologists, i.e. the developers and the users of computational methods for biological data analysis and in that it presents examples of practical applications of the bioinformatics tools in the "daily practice" of an experimental research scientist.

The book starts with reviews on computational methods for protein sequence-structure-function analysis (sequence studies, structure prediction), followed by methods that explicitly utilize experimental data routinely obtained in the laboratory to improve the functional predictions. The second part comprises a series of examples on how particular applications of different types of bio-informatics methods in combination with experimental studies to validate the hypotheses have led to important scientific discoveries. Therefore, the book is a guide to application of bioinformatics methods in molecular biology, addressed mainly to research scientists, postdocs, and advanced graduate students.

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Product Details

ISBN-13:
9783540742678
Publisher:
Springer Berlin Heidelberg
Publication date:
10/28/2007
Series:
Nucleic Acids and Molecular Biology Series, #15
Edition description:
1st ed. 2004. 2nd printing 2007
Pages:
265
Product dimensions:
6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Computational methods for protein structure prediction and fold recognition1
'Meta' approaches to protein structure prediction23
From molecular modeling to drug design35
Structure determination of macromolecular complexes by experiment and computation73
Modeling protein folding pathways97
Structural bioinformatics and NMR structure determination123
Bioinformatics-guided identification and experimental characterization of novel RNA methyltransferases139
Finding missing tRNA modification genes : a comparative genomics goldmine169
Evolution and function of processosome, the complex that assembles ribosomes in eukaryotes : clues from comparative sequence analysis191
Bioinformatics-guided experimental characterization of mismatch-repair enzymes and their relatives221
Predicting functional residues in DNA glycosylases by analysis of structure and conservation243

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