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Practical Bioinformatics / Edition 1

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Overview

The book is unique in that it bridges the gap between bioinformaticists and molecular biologists, i.e. the developers and the users of computational methods for biological data analysis and in that it presents examples of practical applications of the bioinformatics tools in the "daily practice" of an experimental research scientist.

The book starts with reviews on computational methods for protein sequence-structure-function analysis (sequence studies, structure prediction), followed by methods that explicitly utilize experimental data routinely obtained in the laboratory to improve the functional predictions. The second part comprises a series of examples on how particular applications of different types of bio-informatics methods in combination with experimental studies to validate the hypotheses have led to important scientific discoveries. Therefore, the book is a guide to application of bioinformatics methods in molecular biology, addressed mainly to research scientists, postdocs, and advanced graduate students.

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Product Details

  • ISBN-13: 9783540742678
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 10/28/2007
  • Series: Nucleic Acids and Molecular Biology Series , #15
  • Edition description: 1st ed. 2004. 2nd printing 2007
  • Edition number: 1
  • Pages: 265
  • Product dimensions: 6.37 (w) x 9.25 (h) x 0.59 (d)

Table of Contents

Computational methods for protein structure prediction and fold recognition 1
'Meta' approaches to protein structure prediction 23
From molecular modeling to drug design 35
Structure determination of macromolecular complexes by experiment and computation 73
Modeling protein folding pathways 97
Structural bioinformatics and NMR structure determination 123
Bioinformatics-guided identification and experimental characterization of novel RNA methyltransferases 139
Finding missing tRNA modification genes : a comparative genomics goldmine 169
Evolution and function of processosome, the complex that assembles ribosomes in eukaryotes : clues from comparative sequence analysis 191
Bioinformatics-guided experimental characterization of mismatch-repair enzymes and their relatives 221
Predicting functional residues in DNA glycosylases by analysis of structure and conservation 243
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