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Doody's Review ServiceReviewer: M. Joe Ma, M.D., Ph.D.(Associated Pathologists, Chartered)
Description: This book is a description of the diagnostic challenges (neoplastic and non-neoplastic) of surgical neuropathology.
Purpose: Both authors are very experienced in the field and they have, for the most part, succeeded in the inclusion of the most practical information needed for diagnostic consideration.
Audience: The text is surprisingly easy to read despite a few obvious typographic errors, and any surgical pathologist would enjoy the natural flow of information given. Radiologists and neurosurgeons, however, may find the indispensable morphologic details difficult to follow.
Features: The authors begin with a brief introduction to intraoperative consultation, followed by 34 concise chapters of different diseases, each replete with pathology, immunohistochemistry, genetics, clinical history, radiology, differential diagnoses, treatment of choice, and prognostic implications. Most are conveniently summarized in tables. They cover almost all neoplasms in the neuraxis and several important inflammatory diseases. In addition to the popular grading systems of diffuse fibrillary astrocytomas, specific variants of astrocytomas are delineated. The responsiveness to chemotherapy of oligodendrogliomas (well differentiated or anaplastic) and mixed oligoastrocytomas is emphasized. Important mimics of neoplasm, such as multiple sclerosis and radiation necrosis, are discussed separately. Pertinent immunohistochemical findings and caveats (such as immunoreactivity of astrocytic cytoplasm to antibodies against pancytokeratins) are included whenever applicable. All the key features are displayed in photomicrographs, although pathologists and non-pathologists alike may find the black-and-white illustrations less impressive than colored ones. The references in each and every chapter are relevant and quite up-to-date, but this approach results in a few duplicate appearances and possible waste of space.
Assessment: Compared with three other references in surgical neuropathology of similar size: Burger's Tumors of the Central Nervous System (AFIP); Kleihues' Pathology and Genetics: Tumors of the Nervous System (International Agency for Research on Cancer, 1997); and Moss' Intra-Operative Diagnosis of CNS Tumors (Arnold, 1997), this monograph contains very practical information, is very easy to read and comprehend, and is convenient to use in daily intraoperative consultation and regular sign-out.