Practical Fermentation Technology / Edition 1

by Brian McNeil, Linda Harvey

Overview

A hands-on book which begins by setting the context;- defining 'fermentation' and the possible uses of fermenters, and setting the scope for the book. It then proceeds in a methodical manner to cover the equipment for research scale fermentation labs, the different types of fermenters available, their uses and modes of operation. Once the lab is equipped, the issues of fermentation media, preservation strains and strain improvement strategies are documented, along with the use of mathematical modelling as a method for prediction and control. Broader questions such as scale-up and scale down, process monitoring and data logging and acquisition are discussed before separate chapters on animal cell culture systems and plant cell culture systems. The final chapter documents the way forward for fermenters and how they can be used for non-manufacturing purposes. A glossary of terms at the back of the book (along with a subject index) will prove invaluable for quick reference.Edited by academic consultants who have years of experience in fermentation technology, each chapter is authored by experts from both industry and academia. Industry authors come from GSK (UK), DSM (Netherlands), Eli Lilly (USA) and Broadley James (UK-USA).

Product Details

ISBN-13:	9780470014349
Publisher:	Wiley
Publication date:	03/17/2008
Pages:	408
Product dimensions:	6.97(w) x 9.94(h) x 1.09(d)

About the Author

Dr Brian McNeil, Dr Linda Harvey,  Strathclyde Fermentation Centre, Department of Biosciences, Strathclyde University
Leading centre for fermentation research and consultancy in the UK.

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Table of Contents

List of Contributors ix

Acknowledgements xi

Preface xiii

1 Fermentation: An Art from the Past, a Skill for the Future Brian McNeil Linda M. Harvey 1

2 Fermentation Equipment Selection: Laboratory Scale Bioreactor Design Considerations Guy Matthews 3

3 Equipping a Research Scale Fermentation Laboratory for Production of Membrane Proteins Peter C.J. Roach John O'Reilly Halina T. Norbertczak Ryan J. Hope Henrietta Venter Simon G. Patching Mohammed Jamshad Peter G. Stockley Stephen A. Baldwin Richard B. Herbert Nicholas G. Rutherford Roslyn M. Bill Peter J.F. Henderson 37

4 Modes of Fermenter Operation Sue Macauley-Patrick Beverley Finn 69

5 The Design and Preparation of Media for Bioprocesses Linda M. Harvey Brian McNeil 97

6 Preservation of Cultures for Fermentation Processes James R. Moldenhauer 125

7 Modelling the Kinetics of Biological Activity in Fermentation Systems Ferda Mavituna Charles G. Sinclair 167

8 Scale Up and Scale Down of Fermentation Processes Frances Burke 231

9 On-line, In-situ, Measurements within Fermenters Andrew Hayward 271

10 SCADA Systems for Bioreactors Erik Kakes 289

11 Using Basic Statistical Analyses in Fermentation Stewart White Bob Kinley 323

12 The Fermenter in Research and Development Ger T. Fleming John W. Patching 347

Index 377