A Practical Guide to Combinatorial Chemistry

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This book is a practical guide for those engaged in small-molecule com binatorial chemistry as well as those wishing to learn the field. Aime d at nonspecialists, the chapters are written in a tutorial style by i nternationally recognized experts. The text reviews the use of computa tional tools to analyze molecular diversity and presents a detailed su rvey of solid-phase peptide synthesis and the tools used for small-mol ecule synthesis. Up-to-date automated approaches and equipment for syn thesizing solid- and solution-phase libraries are reviewed, including synthesis, analytical, and deconvolution tools. This book will be usef ul to medicinal chemists, organic chemists, biochemists engaged in hig h-throughput screening, materials scientists, patent professionals, an d science writers.

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Editorial Reviews

A practical tutorial-style guide for nonspecialists engaged in small- molecule combinatorial chemistry as well as those wishing to learn the field. Reviews the use of computational tools to analyze molecular diversity, and presents a detailed survey of solid-phase peptide synthesis and the tools used for small-molecule synthesis. Overviews automated approaches and equipment for synthesizing solid- and solution-phase libraries, including synthesis, analytical, and deconvolution tools. For medicinal chemists, organic chemists, biochemists engaged in high-throughput screening, materials scientists, patent professionals, and science writers. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780841234857
  • Publisher: American Chemical Society
  • Publication date: 12/28/1997
  • Series: ACS Professional Reference Book Series
  • Edition description: New Edition
  • Pages: 360
  • Product dimensions: 9.00 (w) x 6.10 (h) x 1.10 (d)

Table of Contents

1 Introduction: Combinatorial Chemistry Approaches the Next Millennium 1
2 Using Computational Tools To Analyze Molecular Diversity 17
3 The Context of Solid-Phase Synthesis 51
4 Synthesis Tools for Solid-Phase Synthesis 99
5 On-Resin Analysis in Combinatorial Chemistry 123
6 Deconvolution Tools for Solid-Phase Synthesis 153
7 Synthesis Tools for Solution-Phase Synthesis 177
8 Analytical Tools for Solution-Phase Synthesis 199
9 Deconvolution Tools in Solution-Phase Synthesis 249
10 Equipment for the High-Throughput Organic Synthesis of Chemical Libraries 281
11 Automated Approaches to Reaction Optimization 309
12 Application of Automated Parallel Synthesis 327
13 Information Management 357
14 Screening of Combinatorial Libraries 399
15 Summary 413
Glossary 417
Abbreviations 433
Index 439
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