Practical Transfusion Medicine / Edition 3

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This new edition of the comprehensive guide to transfusion medicine is now fully revised and updated. The Third Edition includes two new sections, one on alternatives to blood transfusion, and one on cellular and tissues therapy and organ transplantation. It focuses on clinical aspects but also covers background science and organizational issues. This timely volume highlights controversial issues and provides advice for everyday clinical questions in transfusion medicine. Practical Transfusion Medicine, Third Edition, is an essential manual for all those working in modern transfusion medicine.
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Editorial Reviews

From the Publisher
"This book should be a standard reference volume in every blood bank and department of hematology in virtually every hospital. The editors should be commended for compiling such a readable text that is clear and easily understood which also contains consistent themes about transfusion practices and the dangers of allogenic blood." (SABM Newsletter, Summer 2010)
A study guide for trainee hematologists facing exams and a reference for clinical hematology staff looking for solutions to specific problems. British specialists in blood transfusion here provide more detailed information than do handbooks on transfusion medicine, but in a less daunting manner than the standard reference texts. The material might also be of use to oncologists, surgeons, anaesthetists, other clinicians, general and specialist nurses, and scientific and technical staff. It covers basic principles, clinical practice, complications, and practice in blood centers and hospitals. Annotation c. Book News, Inc., Portland, OR (
From The Critics
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is a comprehensive intermediate level book on transfusion medicine.
Purpose: The authors' intent was to provide a comprehensive book on transfusion medicine that would contain more in-depth information than existing handbooks, yet be more concise and user-friendly than standard textbooks.
Audience: The book has broad appeal and would be useful to anyone interested in any aspect of transfusion medicine, including medical technology students, practicing medical technologists, medical students and residents, practicing physicians, and hematology consultants.
Features: The material is divided into five major sections, covering basic principles, clinical practice, complications, practice in blood centers and hospitals, and new developments. The book is concise and well written and the principles are easy to grasp. The illustrations are relatively simple, yet the teaching points are crystal clear. I particularly enjoyed the introduction, which gives an interesting historical perspective to this discipline and hints at the intense political controversies of recent years. The book, however, is authored by individuals residing and practicing in the U.K. and represents the U.K. perspective, which is not consistently aligned with practice in the U.S. Textbooks are often out of date by the time of publication, and this one is no exception. A glaring example is the brief discussion of allogeneic bone marrow transplant for chronic myeloid leukemia (CML), a treatment that has been superseded in recent months by the spectacular clinical success of a newly available oral tyrosine kinase inhibitor medication. Another example is the failure to mention the Parvovirus B19 contamination of batches of solvent detergent treated plasma prepared in the U.S. The desire for brevity also has disadvantages; for example, there is no discussion of the problems that arose when solvent detergent treated plasma was introduced (e.g., donor tracing when each batch is prepared from thousands of donors).
Assessment: This book is best suited for practitioners relatively new to transfusion medicine who desire a more in-depth knowledge than that afforded by handbooks. However, the knowledge of the practicing transfusion or hematology consultant exceeds that contained in this book and more experienced practitioners would be better served by the standard references in this field.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781405181969
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/4/2009
  • Edition number: 3
  • Pages: 576
  • Product dimensions: 7.50 (w) x 9.70 (h) x 1.40 (d)

Meet the Author

Michael F. Murphy MD, FRCP, FRCPath
Professor of Blood Transfusion Medicine, University of Oxford
Consultant Haematologist, NHS Blood & Transplant and Department of Haematology, The John Radcliffe Hospital, Oxford, UK

Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath
Consultant Haematologist, NHS Blood & Transplant
Honorary Clinical Reader, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

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Table of Contents



Preface to the third edition.

Preface to the first edition.

1 Introduction: recent evolution of transfusion medicine (Ian M. Franklin).

Part 1 Basic principles of immunohaematology.

2 Essential immunology for transfusion medicine (Timothy Wallington).

3 Human blood group systems (Geoff Daniels).

4 Human leucocyte antigens (Cristina V. Navarrete).

5 Platelet and neutrophil antigens (David L. Allen, Geoffrey F. Lucas, Michael F. Murphy and Willem H. Ouwehand).

Part 2 Complications of transfusion.

6 Investigation of acute transfusion reactions (Nancy M. Heddle and Kathryn E. Webert).

7 Haemolytic transfusion reactions (Edwin Massey and Geoff Poole).

8 Febrile and allergic transfusion reactions (Cynthia Wu and Nancy M. Heddle).

9 Transfusion-related acute lung injury (Steven H. Kleinman and Ram Kakaiya).

10 Transfusion-related immunomodulation (Morris A. Blajchman and Eleftherios C. Vamvakas).

11 Transfusion-associated graft-versus-host disease and microchimerism (Beth H. Shaz and Christopher D. Hillyer).

12 Post-tranfusion purpura (Michael F. Murphy).

13 Tranfusion-transmitted infections (Alan D. Kitchen and John A.J. Barbara).

14 Bacterial contamination (Patricia E. Hewitt).

15 Variant Creutzfeldt–Jakob disease (Marc L. Turner).

16 Emerging infections and transfusion safety (Roger Y. Dodd).

Part 3 Practice in blood centres and hospitals.

17 Regulatory aspects of blood transfusion (Joan Jones and Adrian Copplestone).

18 The role of haemovigilance in transfusion safety (James P. AuBuchon).

19 Donors and blood collection (William Murphy and Ellen McSweeney).

20 Blood donation testing and the safety of the blood supply (David Wenham, Lisa Byrne and Simon J. Stanworth).

21 Production and storage of blood components (Rebecca Cardigan and Lorna M. Williamson).

22 Medicolegal aspects of transfusion practice (Patricia E. Hewitt).

23 Blood transfusion in hospitals (Sue Knowles and Geoff Poole).

24 Blood transfusion in a global context (David J. Roberts, Jean-Pierre Allain, Alan D. Kitchen, Stephen Field and Imelda Bates).

Part 4 Clinical transfusion practice.

25 Good blood management: the effective and safe use of blood components (Brian McClelland and Tim Walsh).

26 Prenatal and childhood transfusions (Irene Roberts).

27 Haematological disease (Michael F. Murphy and Simon J. Stanworth).

28 Blood transfusion in the management of patients with haemoglobinopathies (David Rees).

29 Massive blood loss (Beverley J. Hunt).

30 Inherited and acquired coagulation disorders (Vickie McDonald, J. Kim Ryland, Joanne E. Joseph and Samuel J. Machin).

31 Recombinant proteins in diagnosis and therapy (Marion Scott).

32 Immunodeficiency and immunoglobulin therapy (Siraj A. Misbah).

Part 5 Alternatives to transfusion.

33 The principles of bloodless medicine and surgery (Aryeh Shander and Lawrence Tim Goodnough).

34 Autologous transfusion (Dafydd Thomas and John Thompson).

35 Blood substitutes (Chris V. Prowse and David J. Roberts).

36 Pharmacological agents and recombinant factor VIIa (Beverley J. Hunt).

Part 6 Cellular and tissues therapy and organ transplantation.

37 Regulation and accreditation in cellular therapy (Derwood H. Pamphilon and Zbigniew M. Szczepiorkowski).

38 Stem cell collection and therapeutic apheresis (Khaled El-Ghariani).

39 Haemopoietic stem cell processing and storage (David H. McKenna Jr and Mary E. Clay).

40 Haemopoietic stem cell transplantation (I. Grant McQuaker and Ian M. Franklin).

41 Cord blood transplantation (Leandro de Padua Silva, Marcos de Lima, Elizabeth J. Shpall and Susan Armitage).

42 Recent advances in clinical cellular immunotherapy (Mark W. Lowdell and Emma Morris).

43 Cytokines in transfusion practice (Derwood H. Pamphilon and Michael F. Murphy).

44 Tissue banking (Ruth M. Warwick and Deirdre Fehily).

45 Transfusion strategies in organ transplant patients (Anneke Brand and Derwood H. Pamphilon).

Part 7 Development of the evidence base for transfusion.

46 The design of interventional trials in transfusion medicine (Paul C. H´ebert, Alan T. Tinmouth and Dean Fergusson).

47 Getting the most out of the evidence for transfusion medicine (Simon J. Stanworth, Susan J. Brunskill, Carolyn Doree and Chris J. Hyde).

48 How to influence clinicians’ use of blood – improving the transfusion practice in hospitals? (Simon J. Stanworth, J.J. Francis, M.P. Eccles, Chris J. Hyde, Michael F. Murphy and Alan T. Tinmouth).

49 Scanning the future of transfusion medicine (Walter H. Dzik).


Colour plates can be found facing page.

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