Preclinical and Clinical Development of New Vaccines: Symposium, Institut Pasteur, Paris, May, 1997 / Edition 1

Paperback (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $105.02
Usually ships in 1-2 business days
(Save 66%)
Other sellers (Paperback)
  • All (2) from $105.02   
  • New (1) from $320.25   
  • Used (1) from $105.02   

Product Details

Table of Contents

David Magrath Memorial Lecture 1
Lessons Learned from the Development of Poliovaccines 3
Vaccines, Human Experimentation, and Ethics in Evolutionary Perspective 13
Overview of Current Preclinical Testing Strategies for Viral Vaccines 19
Review of Current Preclinical Testing Strategies for Bacterial Vaccines 25
A Respiratory Challenge Model for Infection with Bordetella pertussis: Application in the Assessment of Pertussis Vaccine Potency and in Defining the Mechanism of Protective Immunity 31
DNA Vaccines 43
A Phased Approach to Clinical Testing: Criteria for Progressing from Phase I to Phase II to Phase III Studies 57
Natural History and Pathogenesis as they Affect Clinical Trials 61
Regulatory Aspects of Clinical Trials with Vaccines 69
Epidemiological Factors in Clinical Trial Design 75
Clinical Evaluation of New Pneumococcal Vaccines: the Finnish Approach 85
Assessment of Human CD4+ and CD8+ T Lymphocyte Responses in Experimental Viral Vaccine Studies 95
B Cell Responses and Immune Memory 105
Immunological Issues in Vaccine Trials: T-Cell Responses 117
Immunisation and the Maturation of Infant Immune Responses 125
Maternal Immunity and Infant Responses to Immunization: Factors Influencing Infant Responses 133
Mucosal Responses to Parenteral and Mucosal Vaccines 141
HIV-1 DNA Based Vaccine Induces a CD8 Mediated Cross-Clade CTL Response 147
Standardization of Acellular Pertussis Vaccine by Assay of Serum Neutralizing Antibodies to Pertussis Toxin (Antitoxin): Analogy with Diphtheria Toxoid 155
Standardization May Suffice for Licensure of Conjugate Vaccines 161
Experimental Challenge Studies in the Development of Vaccines for Infectious Diseases 169
Immunogenicity Assays and Surrogate Markers to Predict Vaccine Efficacy 175
Bridging Studies 181
Long-Term Efficacy of Pertussis Vaccines in Italy 189
Measuring Protection: Efficacy Versus Effectiveness 195
Monitoring and Safety Assessment in Phase I to III Clinical Trials 203
Measuring Protection; a Case Study of Pertussis Vaccines - Swedish Trial II: Secondary Non-Randomized Comparisons Between two Schedules of Infant Vaccination 211
Measurement of Human Serum IgG Antibodies or a Surrogate is Sufficient to Standardize (Predict Efficacy) Vaccines 221
Mathematical Modelling of Effectiveness 225
Safety Assessment Post-Licensure 235
Clinical Safety Evaluation of Combination Vaccines 245
Development and Efficacy Assessment of Combination Vaccines, with Emphasis on Acellular Pertussis 251
From Immunisation Research to Policy and Implementation 257
Summary and Conclusions 261
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)