Preclinical Drug Development by Mark C. Rogge, Rogge C. Rogge |, Hardcover | Barnes & Noble
Preclinical Drug Development

Preclinical Drug Development

by Mark Rogge
     
 

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Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials.

Highlights of the Second Edition include:

Overview

Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials.

Highlights of the Second Edition include:

  • Pharmacokinetics
  • Modeling and simulation
  • Formulation and routes of administration
  • Toxicity evaluations
  • The assessment of drug absorption and metabolism
  • Interspecies scaling
  • Lead molecule selection and optimization via profiling
  • Screening using in silico and in vitro toxicity evaluations

The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences.

Product Details

ISBN-13:
9781420084726
Publisher:
Taylor & Francis
Publication date:
09/25/2009
Series:
Drugs and the Pharmaceutical Sciences Series, #187
Pages:
384
Product dimensions:
7.10(w) x 10.10(h) x 1.00(d)

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