Prenatal Exposures in Schizophrenia / Edition 1

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1999 New pp. 275. Light blemishes on page block edges.

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Arlington, Virginia, U.S.A. 1999 Hardcover New 0880484993. BRAND NEW, FLAWLESS COPY, NEVER OPENED--296 pages. "One of the most devastating of illnesses, schizophrenia remains ... something of a mystery for scientists and psychiatrists trying to pinpoint its causes, understand its effects, and find a cure. Although we know that schizophrenia is an inherited disorder, new clues point to the probability that genes are only partly responsible for the disease. A growing body of evidence suggests that schizophrenia is often the result of environmental factors combined with a genetic predisposition. In Prenatal Exposures in Schizophrenia, a group of distinguished scientists considers a range of epigenetic elements thought to interact with abnormal genes to produce the onset of illness. The authors pay particular attention to the evidence implicating obstetric complications, prenatal infection, autoimmunity, and prenatal malnutrition in brain disorders. Chapters are arranged within four sections: Schizophrenia and bra Read more Show Less

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Overview

One of the most devastating of illnesses, schizophrenia remains something of a mystery for scientists and psychiatrists trying to pinpoint its causes, understand its effects, and find a cure. Although we know that schizophrenia is an inherited disorder, new clues point to the probability that genes are only partly responsible for the disease. A growing body of evidence suggests that schizophrenia is often the result of environmental factors combined with a genetic predisposition.

In Prenatal Exposures in Schizophrenia, a group of distinguished scientists considers a range of epigenetic elements thought to interact with abnormal genes to produce the onset of illness. The authors pay particular attention to the evidence implicating obstetric complications, prenatal infection, autoimmunity, and prenatal malnutrition in brain disorders. Chapters are arranged within four sections: • Schizophrenia and brain development• Prenatal infectious exposures• Prenatal nutritional exposures• Prenatal immunological exposures

The book uses new findings on the effects of environment combined with genetics to shed light not only on the causes of schizophrenia, but also on preventive measures and potential cures.

In recent years, evidence has emerged that early and sustained intervention with antipsychotic medication can reduce the duration and severity of schizophrenic symptoms. Now, by identifying events during pregnancy that place the fetus at risk for developing schizophrenia and taking steps to prevent them, the outlook for decreasing the morbidity and perhaps even the incidence of schizophrenia has never been more promising.

American Psychiatric Publishing

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Nancy Schell, MD (Rush University Medical Center)
Description: This book brings together top investigators to discuss the role of prenatal factors in schizophrenia.
Purpose: The purpose is to consider the wide range of "epi-genetic" elements that may interact with abnormal genes in the development of schizophrenia.
Audience: It is intended for scientists and clinicians interested in schizophrenia and its possible etiologies.
Features: Evidence suggesting the disease may be the result of environmental factors combined with genetic predisposition is examined. The editors persuasively propose that schizophrenia may result from neurodevelopmental processes beginning before birth. The chapters are divided into four main sections, the first presenting overviews of conceptual models of prenatal influences and the remaining three focusing on infectious, nutritional, and immunological exposures. This book is up-to-date and thorough, yet easy to read, with presentation of ideas and data in an easy to understand framework. References are excellent and the contributors are distinguished in this field.
Assessment: This is an extremely useful book for those interested in the latest research on schizophrenia and, in particular, how it may develop. It is highly recommended.
Nancy P. Schell
This book brings together top investigators to discuss the role of prenatal factors in schizophrenia. The purpose is to consider the wide range of "epi-genetic" elements that may interact with abnormal genes in the development of schizophrenia. It is intended for scientists and clinicians interested in schizophrenia and its possible etiologies. Evidence suggesting the disease may be the result of environmental factors combined with genetic predisposition is examined. The editors persuasively propose that schizophrenia may result from neurodevelopmental processes beginning before birth. The chapters are divided into four main sections, the first presenting overviews of conceptual models of prenatal influences and the remaining three focusing on infectious, nutritional, and immunological exposures. This book is up-to-date and thorough, yet easy to read, with presentation of ideas and data in an easy to understand framework. References are excellent and the contributors are distinguished in this field. This is an extremely useful book for those interested in the latest research on schizophrenia and, in particular, how it may develop. It is highly recommended.
Booknews
Considers a range of epigenetic elements thought to interact with abnormal genes to produce the onset of illness, paying particular attention to the evidence implicating obstetric complications, prenatal infection, autoimmunity, and prenatal nutrition in brain disorders. Uses new findings on the effects of environment combined with genetics to shed light not only on the causes of schizophrenia, but also on preventive measures and potential cures. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780880484992
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 3/28/1999
  • Series: Progress in Psychiatry Series
  • Edition description: 1 ED
  • Edition number: 1
  • Pages: 296
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.00 (d)

Meet the Author

Ezra S. Susser, M.D., Dr.P.H., is Chair of the Division of Epidemiology, at the Joseph L. Mailman School of Public Health at Columbia University. He is also Professor of Clinical Psychiatry in Public Health at Columbia University and the Head of the Developmental Brain Disorders Department at the New York State Psychiatric Institute in New York, New York.

Alan S. Brown, M.D., is Assistant Professor of Psychiatry in the College of Physicians and Surgeons of Columbia University at the New York State Psychiatric Institute in New York, New York.

Jack M. Gorman, M.D., is Professor of Psychiatry in the College of Physicians and Surgeons of Columbia University at the New York State Psychiatric Institute in New York, New York.

American Psychiatric Publishing

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Table of Contents

Schizophrenia and Brain Development. Schizophrenia: evidence for its neurodevelopmental origins. Interaction of genes and prenatal exposures in schizophrenia. Prenatal development of the brain. Prenatal Infectious Exposures. Seasonality, prenatal influenza, and schizophrenia. Plausibility of prenatal viral infection as a risk factor for schizophrenia. Prenatal Nutritional Exposures. The Dutch Famine Studies: prenatal nutritional deficiency and schizophrenia. Plausibility of early nutritional deficiency as a risk factor for schizophrenia. Prenatal Immunological Exposures. Rhesus incompatibility and schizophrenia. Heat shock proteins and autoimmune mechanisms of disease in schizophrenia. Conclusion. Schizophrenia: closing the gap between genetics, epidemiology, and prevention. Index.

American Psychiatric Publishing

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