Preterm Birth: Prevention and Management / Edition 1

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Preterm birth is an increasing challenge in the developed and developing world. As we begin to understand what contributes to the likelihood of preterm birth, obstetricians and gynecologists can advise mothers and aspiring mothers on how to minimize the risks. Doctors can also monitor those patients who are likely to be at risk to increase the chances of preventing or effectively managing preterm labor.

This practical book provides a clinically focused approach to the prevention and management of premature births, using the best available evidence to provide clear guidance to obstetricians, gynecologists, nurse midwives and family practitioners. Written for an international audience, the author addresses the special issues affecting patients in the developing world, including infectious-and poverty-related preterm birth.

Each of the 30 chapters follows a wealth of practical features:

Key points and chapter summaries

Algorithms, tables and graphs

Summary of the evidence-based literature

Easy-to-use clinical guidelines

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Editorial Reviews

From the Publisher
"This is an excellent reference that covers the pathophysiology and potential interventions for this global health problem. The credibility of the authors lends added weight to the book." (Doody's, 7 October 2011)
Doody's Review Service
Reviewer: Anthony Shanks, MD (Washington University School of Medicine)
Description: This is an evidence-based resource that attacks the significant health problem of preterm birth from multiple angles.
Purpose: The purpose is to investigate the epidemiology of preterm birth and discuss the pathophysiology and interventions that attempt to decrease it.
Audience: The book is aimed at physicians and physicians in training in the field of obstetrics. All physicians would find it interesting, but those who work in high-risk obstetrics may find it most helpful. The authors are some of the most respected names in the field of maternal-fetal medicine.
Features: The economic and medical burden of preterm birth is supported by statistics in the introductory chapter on the global impact of preterm birth. Given the multifactorial nature of preterm birth, subsequent chapters break down each problem individually. Genetics of preterm birth, the cervix, and inflammation are just some of the areas that the book chooses to tackle. The excellent chapter on the genetics of preterm birth has an interesting spin on the genetic associations of preterm birth and, thankfully, the author stops short of recommending routine genetic testing. Chapter 6, on the cervix, and chapter 12, on short cervical length, are two very important chapters on conditions that are the source of many referrals to maternal-fetal medicine specialists. Chapter 6 presents the physiology of cervical disorders and its association with preterm birth while chapter 12 takes the clinical perspective, discussing what to do with this information. Certainly these two chapters could have been presented next to each other, but that is a small quibble. Chapter 20 is a nice treatment of fetal lung maturation. Given that antenatal steroids have been proven to improve neonatal morbidity and mortality, it is essential to have an adequate discussion of this in a book on preterm birth. This chapter is very thorough, although the author comes down on the side of not providing rescue steroids. That is certainly an acceptable management strategy, but the language in the Committee Opinion from ACOG (February 2011) seems to advocate the other side.
Assessment: This is an excellent reference that covers the pathophysiology and potential interventions for this global health problem. The credibility of the authors lends added weight to the book.
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Product Details

  • ISBN-13: 9781405192903
  • Publisher: Wiley
  • Publication date: 5/4/2010
  • Edition number: 1
  • Pages: 304
  • Product dimensions: 6.90 (w) x 9.70 (h) x 0.90 (d)

Meet the Author

Vincenzo Berghella, MD, Professor of Obstetrics and Gynecology, Director of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA

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Table of Contents

List of Contributors vii

Definitions xi

Abbreviations xii

Preface xiii

1 The Global Impact of Preterm Birth Jennifer Harris Requejo Mario Merialdi 1

2 Preterm Birth: A Complex Disease Eric J. Hodgson Charles J. Lockwood 8

3 Why Prevention? Jason K. Baxter 17

4 The Epidemiology of Preterm Birth Robert L. Goldenberg Elizabeth M. McClure 22

5 Genetics of Preterm Birth Heidi L. Thorson Hyagriv N. Simhan 39

6 The Cervix Vincenzo Berghella 50

7 Inflammation and Infection Roberto Romero Francesca Gotsch Shali Mazaki-Tovi Juan Pedro Kusanovic 57

8 The Endocrine Regulation of Human Labor Roger Smith Julia I. Smith Andrew M. Bisits 78

9 Preventive Issues for All Gravidas Priyadarshini Koduri 88

10 Tobacco and Preterm Birth Jeroen P. Vanderhoeven Jorge E. Tolosa 102

11 Care for Women with Prior Preterm Birth Jay D. Iams 115

12 Short Cervical Length Timothy J. Rafael 130

13 Fetal Fibronectin Maria Bisulli 149

14 Bacterial Vaginosis Nancy W. Hendrix 161

15 Sexually Transmitted Infections Neil S. Seligman 171

16 Multiple Gestations: Preventing and Managing Preterm Birth Edward J. Hayes Suneet P. Chauhan 183

17 Asymptomatic Manual Cervical Changes Leonardo Pereira 190

18 Preterm Labor Amen Ness Yair Blumenfeld Joyce F. Sung 198

19 Preterm Premature Rupture of the Membranes Brian M. Mercer 217

20 Promotion of Fetal Maturation Kellie E. Murphy 232

21 Location, Mode of Delivery and Intrapartum Issues for the Preterm Gestation Dana Figueroa Dwight J. Rouse 242

22 Perinatal Care and Long-Term Implications Janet E. Larson Shobhana A. Desai William McNett 252

23 Ethical Issues Related to Preterm Birth Frank A. Chervenak Laurence B. McCullough 262

24 Future Research Catherine Y. Spong 270

Index 275

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