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Doody's Review ServiceReviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: This is an excellent guide to the currently available techniques to create genetically engineered stem cells that could be used to create disease models and screens, or cells for therapeutic applications.
Purpose: The purpose is to bridge the concepts of genetic engineering with primary and stem cells and to provide an understanding of cell engineering principles and outline their applications in primary and stem cells.
Audience: The book is written for researchers entering the field as well as established stem cell scientists looking to expand their areas of research. Graduate students interested in this field also will find this book very useful.
Features: The four parts of the book cover cloning and gene delivery, nonintegrating technologies, integrating technologies, and applications. Each chapter in these parts discusses a new technology and its applications in primary and stem cells. The book is well illustrated with beautiful figures.
Assessment: This is an excellent resource on the new techniques for the engineering of stem cells and the delivery of transgenes into stem cells via various viral and nonviral systems. It provides comprehensive information on the concepts of cell engineering principles and their application in primary and stem cells. Researchers, established stem cell scientists, and graduate students interested in this field will find this book very handy.