Primary Immunodeficiency Diseases: A Molecular & Cellular Approach / Edition 2

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $40.61
Usually ships in 1-2 business days
(Save 67%)
Other sellers (Hardcover)
  • All (6) from $40.61   
  • New (3) from $79.62   
  • Used (3) from $40.61   
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any coupons and promotions
Seller since 2010

Feedback rating:



New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

"New, ships through UPS and DHL. Excellent customer service. Satisfaction guaranteed!! "


Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2014

Feedback rating:


Condition: New
Hardcover New in new dust jacket. Brand New US edition, 3-5 days shipping!

Ships from: foxboro, MA

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
  • Express, 48 States
  • Express (AK, HI)
Seller since 2009

Feedback rating:


Condition: New
Hardcover New 019514774X Special order direct from the distributor.

Ships from: Victoria, Canada

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
  • Express, 48 States
  • Express (AK, HI)
Page 1 of 1
Showing All
Sort by


The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders—disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.

The book contains predominantly black-and-white illustrations, with some color illustrations.

Read More Show Less

Editorial Reviews

From the Publisher
"This latest edition of Primary Immunodeficiency Diseases emphasized the molecular bases of these disorders, but there are also thorough discussions of their clinical aspects, and these will make the book an important addition to the library of any physician who treats patietns with primary immunodeficiencies."—New England Journal of Medicine
New England Journal of Medicine
Most of our current understanding of how the human immune system functions has been derived from the lessons learned from patients with these rare disorders. With this exciting and useful book as a guide, the interested reader will be well informed as to the current clinical state of affairs and the biologic advances that will continue to be made by studying these diseases.
Read More Show Less

Product Details

  • ISBN-13: 9780195147742
  • Publisher: Oxford University Press, USA
  • Publication date: 8/24/2006
  • Edition description: REV
  • Edition number: 2
  • Pages: 776
  • Product dimensions: 11.00 (w) x 8.80 (h) x 2.10 (d)

Table of Contents

1. Genetically Determined Immunodeficiency Diseases: A Perspective, C.I. Edward Smith, Hans D. Ochs, and Jennifer M. Puck
2. Genetic Principles and Technologies in the Study of Immune Disorders, Jennifer M. Puck and Robert L. Nussbaum
3. Mammalian Hematopoietic Development and Function, Gerald J. Sprangrude
4. T-Cell Development, Rae S. M. Yeung, Josef M. Penninger, and Tak W. Mak
5. Molecular Mechanisms Guiding B-Cell Development, Antonius Rolink, Jan Andersson, Ulf Grawunder, and Fritz Melchers
6. Signal Transduction by T and B Lymphocyte Antigen Receptors, Neetu Gupta, Anthony L. DeFranco, and Arthur Weiss
7. Regulation of Lymphocyte Responses, Cell Trafficking and Lymphoid Organ Development, Sirpa Jalkanen and Marko Salmi
8. The Phagocytic System, Kuender D. Yang, Anthony Segal, Harry R. Hill
Part II Syndromes.
9. X-linked Severe Combined Immunodeficiency, Jennifer M. Puck
10. Autosomal Recessive SCID Due to Defects of Cytokine Signaling Pathways, Fabio Candotti and Luigi Notarangelo
11. Recombination Defects, Anna Villa, Klaus Schwarz, and , J.P. Villartay
12. Immunodeficiency Due to Defects of Purine Metabolism, Rochelle Hirschhorn, Fabio Candotti
13. CD45 Deficiency, Markku Heikinheimo and Talal Chatila
14. SCID Due to Defects in T-Cell-Receptor-Associated Protein Kinases, Melissa E. Elder
15. Human Interleukin-2 Receptor Alpha Deficiency, Chaim M. Roifman
16. CD3 and CD8 Deficiencies, Jose R. Regueiro Teresa Espanol et al.
17. Molecular Basis of Major Histocompatibility Complex Class II Deficiency, Walter Reith, Barbara Lisowska-Grospierre, and Alain Fischer
18. Peptide Transporter Defects in HLA Class I Deficiency, Henri de la Salle, Lionel Donato, Daniel Hanau, and Marie-Marthe Tongio
19. CD40, CD40 Ligand, and theHyper-IgM Syndrome, Raif S. Geha, Alessandro, and Luigi Notarangelo
20. Autosomal Hyper-IgM Syndromes Caused by an Intrinsic B-cell Defect, Anne Durandy, Patrick Revy, and Alain Fischer
21. X-linked Agammaglobulinemia: A Defect of Btk Tyrosine Kinase, C.I. Edvard Smith and Owen N. Witte
22. Autosomal Recessive Agammaglobulinemia, Mary Ellen Conley
23. Genetic Approach to Common Variable Immunodeficiency and IgA Deficiency, Lennart Hammarstrm and C.I. Edvard Smith
24. Defects in Apoptosis with Autoimmune Manifestations, Jennifer M. Puck, Stephen E. Straus, Francoise Le Deist, Frederic Rieux-Laucat
25. Autoimmune Polyendocrinopathy, Candidiasis and Ectodermal Dystrophy (APECED), Leena Peltonen, Maria Halonen, and Jaakko Perheentupa
26. Immune Dysregulation, Polyendocrinopathy, Enteropathy; X-linked (IPEX), Hans D. Ochs, Mary E. Brunkow, and Steve Siegler
27. Periodic Fever Syndromes, Daniel Kastner, Susannah Brydges, and Keith M. Hull
28. Inherited Disorders of the Interleukin-12/23-Interferon Gamma Axis, Melanie Newport, Steve Holland, Michael Levin, and Jean-Laurent Casanova
29. Ataxia-Telangiectasia, Martin F. Lavin and Yosef Shiloh
30. DNA Breakage and Repair Associated Syndromes Other Than Ataxia-Telangiectasia, Karl Sperling, Markus Stumm, James German, Fanconi expert (e.g. Johnson Liu/French woman/Dutch)
31. The Wiskott-Aldrich Syndrome, Hans D. Ochs, Fred S. Rosen
32. X-linked Lymphoproliferative Disease (XLP) due to Defects of SH2D1A, Volker Schuster and Cox Terhorst
33. DiGeorge Syndrome: A Chromosome 22q11.2 Deletion Syndrome, Deborah A. Driscoll and Kathleen E. Sullivan
34. Hyper IgE Recurrent Infection Syndromes, Bodo Grimbacher and Stevn M. Holland
35. Immunodeficiency with Centromere Instability and Facial Anomalies, Scott Hansen, Corry Weemaes, and Cisca Wijmenga
36. Immunodeficiencies with Associated Manifestations of Skin, Hair, Teeth, and Skeleton, Mario Abinun, Ilkka Kaitila and Jean-Laurent Casanova
37. Chronic Granulomatous Disease, Dirk Roos, Taco W. Kuijpers, and John T. Curnutte
38. Cell Adhesion and Leukocyte Adhesion Defects, Amos Etzioni and John M. Harlan
39. Cyclic and Congenital Neutropenia Due to Defects in Neutrophil Elastase, David Dale and Andrew Aprikyan
40. Chediak-Higashi Syndrome, Richard A. Spritz
41. Inherited Hemophagocytic Syndromes, Genevive de Saint Basile
42. Genetically Determined Deficiencies of the Complement System, Kathleen E. Sullivan and Jerry A. Winkelstein
Part III Assessment and Treatment.
43. Assessment of the Immune System, Helen M. Chapel, Siraj Misbah, and David Webster
44. Genetic Aspects of Primary Immunodeficiencies, Jennifer M. Puck
45. Immunodeficiency Information Systems, Jouni Valiaho, Crina Samarghitean, Hilkka Piirila, Marianne Pusa, and Mauno Vihinen
46. Conventional Therapy of Primary Immunodeficiency Diseases, E. Richard Stiehm and Helen M. Chapel
47. Bone Marrow Transplantation for Primary Immunodeficiency Diseases, Rebecca H. Buckley and Alain Fischer
48. Gene Therapy, Fabio Candotti and Alain Fischer

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)