Primer on Transplantation / Edition 2

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Primer on Transplantation Second Edition is an important reference for individuals, students, fellows, faculty and practitioners with an interest in the transplantation of life-saving organs. This second edition is longer than the first, in order to include new material on transplantation. As in the first edition, this volume contains information about kidney, heart, liver, and lung transplantation to allow students and practitioners to 'see how it's done.' But because there is so much information common to transplant recipients--irregardless of the organ involved--the author has added a new section entitled Medical Complications of Transplantation, which covers topics like heart disease in non-heart transplant patients and liver disease in non-liver transplant patients. This section also has valuable information on bone, eye and skin diseases and reproduction in transplant patients. The remaining [generic] sections of the book include updated information on the immunologic basis of transplantation, tissue typing, pharmacology, and immunosuppressive drugs, as well as a new chapter on understanding, interpreting and conducting transplantation research.
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Editorial Reviews

Doody's Review Service
Reviewer: Jeffrey S. Crippin, M.D.(Washington University School of Medicine)
Description: This is an overview of solid organ transplantation directed at those new to the field. first edition appeared four to five years ago.
Purpose: The purpose is to provide a reference for students, housestaff, fellows, and practitioners interested in the field of solid organ transplantation. There is no similar book that encompasses ALL aspects of solid organ transplantation, including transplantation immunology, the pharmacology of immunosuppressive medications, with separate sections on heart, lung, liver, kidney, and pancreas transplantation. The editors have done a masterful job in attaining this goal.
Audience: The book is directed at those new to the field, though transplant physicians and surgeons can certainly use it as an update on aspects of the field with which they lack familiarity. Furthermore, the information provided on other solid organ transplants is helpful for the physician whose practice may encompass the care of patients who have received different organs, e.g., nephrologists and infectious disease specialists. The editors, recognized leaders in their respective fields, have successfully attained this goal.
Features: The book covers the immunobiology of transplantation, the pharmacology of transplantation, medical complications of transplantation, organ procurement, the economics of transplantation, and has separatre sections on heart, lung, kidney/pancreas, and liver transplantation. The sections on medical complications and pharmacology are relatively unique to this book, and are particularly helpful to a primary care physician. The book also provides a list of recommended readings at the end of each chapter, supplying the trainee with a useful list of focused manuscripts for further study.
Assessment: This is a useful reference for those actively involved in the field, as well as for those peripherally involved in the care of transplant patients. In the face of nearly daily advances in the field, the second edition provides a useful update to the initial edition.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780966015010
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/15/2001
  • Edition description: REV
  • Edition number: 2
  • Pages: 768
  • Product dimensions: 8.75 (w) x 11.30 (h) x 1.50 (d)

Table of Contents

I. Immonobiology and Transplant Research.

1. Historical Overview.

2. Normal Immune Responses.

3. Immune Response to Allografts.

4. Inflamatory Response to Allografts.

5. Mechanisms of Tolerance.

6. Basic Immunogenetics.

7. Clinical Immunogenetics.

8. Xenotransplantation.

II. Pharmacology and Immunosuppression.

9. Historical Overview of Pharmacology and Immunosuppression.

10. Basic Principles of Pharmacology.

11. Principles and Overview of Immunosuppression.

12. Commonly Used Drugs and Drug Interactions.

13. Design and Interpretation of Clinical Trials in Transplantation.

14a. Action, Efficacy and Toxicities: Cyclosporine.

14b. Action, Efficacy and Toxicities: Tacrolimus.

14c. Action, Efficacy and Toxicities: Mycophenolate Mofetil.

14d. Action, Efficacy and Toxicities: Azathioprine.

14e. Action, Efficacy and Toxicities: Corticosteroids.

14f. Action, Efficacy and Toxicities: Polyclonal Antilymphocyte Antibodies.

14g. Action, Efficacy and Toxicities: Anti-CD3 Monoclonal Antibodies.

14h. Action, Efficacy and Toxicities: Anti-CD25 Monoclonal Antibodies.

14i. Action, Efficacy and Toxicities: Rapamycin.

15. Nonbiologics.

16. Investigational Immunosuppressive Agents: Biologicals.

III. Organ Procurement/Economics.

17. Cadaver Donor Management.

18. Economics of Transplantation.

IV. Medical Complications of Transplantation.

19. Heart Disease in Non-Heart Transplant Patients.

20. Principles of Infectious Disease Management for the Organ Transplant Recipient.

21. Kidney Disease in Nonrenal Transplantation.

22. Liver Disease in Non-Liver Transplant Patients.

23. Lung Disease in Non-Lung Transplant Patients.

24. Metabolic Complications.

25. Bone Disease Following Transplantation.

26. Neoplasia Following Transplantation.

27. Transplantation and Reproductive Health.

28. Diseases of the the Skin Following Transplantation.

29. Ocular Complications in Transplant Patients.

30. Long-term Management of the Transplanted Patient: Health Maintenance Issues.

31. Special Issues in Pediatric Organ Transplantation.

V. Heart Transplantation.

32. Historical Overview of Heart Transplantation.

33. Evaluation and Management of Prospective Heart Recipients.

34. Living Heart Donors -- Domino Heart Transplantation.

35. Cadaver Heart Donor Selection Criteria.

36. The Continuing Evolutions of Donor Heart Allocation.

37. Heart Transplantation: Technical Tips to the Surgical Procedure.

38.Immediate Postoperative Management of the Heart Transplant Recipient.

39. Physiology of the Transplanted Heart.

40. Induction Immunosuppression Protocols for Heart Transplantation.

41. Left Ventricular Dysfunction after Cardiac Transplantation: Etiologies, Diagnosis and Treatment.

42. Pathologic Findings of Cardiac Dysfunction.

43. Long-Term Management Issues in Heart Transplantation.

44. Maintenance Immunosuppression Protocols for Heart Transplantation.

45. Expected Clinical Outcomes -- Risk Factors for Heart Transplantation.

46. Special Considerations in Pediatric Heart Transplantation.

47. Heart-Lung Transplantation.

VI. Kidney and Pancreas Transplantation.

48. History of Kidney and Pacreas Transplantation.

49. Evaluation and Management of Prospective Kidney Patients.

50. Living Kidney Donor Evaluation and Selection.

51. Cadaver Kidney Donor Selection.

52. Sharing and Allocation.

53. Technical Aspects of Renal Transplantation.

54. Immediate Postoperative Management of the Kidney Transplant Recipient.

55. Physiology of the Transplanted Kidney.

56. Induction Immunosuppression Protocols for Kidney Transplantation.

57. Diagnosis and Treatment of Renal Dysfunction Episodes.

58. Pathologic Findings of Renal Allogaft Dysfunction.

59. Long-Term Management Issues in Kidney Transplantation.

60. Maintenance Immunosuppression Protocols for Kidney Transplantation.

61. Expected Clinical Outcomes -- Risk Factors in Kidney Transplantation.

62. Special Considerations in Pediatric Kidney Transplantation.

63. Pancrease and Simultaneous Kidney-Pancreas Transplantation.

64. Pancreatic Islet Cell Transplantation.

VII. Liver and Intestinal Transplantation.

65. Historical Overview of Liver Transplantation.

66. Evaluation and Management of Prospective Liver Transplant Candidates.

67. Living-Related Liver Transplantation: Selection and Recipient Donors.

68. Cadaver Liver Donor Selection Criteria.

69. Liver Donor Allocation Scheme.

70. Surgical Techniques in Liver Transplantation.

71. Immediate Postoperative Management of the Liver Transplant Patient.

72. Physiology of the Transplanted Liver.

73. Induction Immunosuppression Protocols for Liver Transplantation.

74. Diagnosis and Treatment of Hepatic Allograft Dysfunction.

75. The Histopathology of Liver Allograft Dysfunction.

76. Long-Term Issues in Liver Transplantation.

77. Mantenance Immunosuppression for Liver Transplantation.

78. Expected Clinical Outcomes/Risk Factores for Liver Transplantation.

79. Special Considerations in Pediatric LIver Transplantation.

80. Clinical Intestinal Transplantation: Recent Advances and Future Consideration.

81. Hepatocyte Transplantation.

VIII. Lung Transplantation.

82. Lung Transplantation - Historical Perspective.

83. Evaluation and Mangement of Prospective Lung and Lung-Heart Recipients.

84. Living-Donor Lobar Lung Transplantation: Donor Evaluation and Selection.

85. Living-Donor Lung Transplantation: Surgical Technique and Perioperative Management.

86. Cadaver Lung Donor Selection Criteria.

87. Cadaver Lung Donor Allocation Scheme.

88. Lung and Heart-Lung Transplant Surgical Procedure.

89. Immediate Postoperative Management of the Lung Transplant Recipient.

90. Physiology of the Transplanted Lung.

91. Induction Immunosuppression Protocols for Lung Transplantation.

92. Diagnosis and Treatment of Pulmonary Dysfunction Episodes.

93. Pathology of Pulmonary Allograft Dysfunction.

94. Long-Term Management Issues in Lung Transplantation.

95. Maintenance Immunosuppression Protocols for Lung Transplantation.

96. Lung Transplantation: Outcomes.

97. Pediatric Lung Transplantation: Special Considerations and Remaining Hurdles

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