Principles and Practice of Fertility Preservation

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The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

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Editorial Reviews

Doody's Review Service
Reviewer: Patricia T Jimenez, MD (Washington University School of Medicine)
Description: This is a comprehensive review of the biology of cancer and the implications for reproductive health, as well as fertility preservation options for men and women.
Purpose: The purpose is to provide a resource about the quickly evolving field of fertility preservation. This is becoming a much more important issue as advances in cancer therapy lead to longer survival and as women delay childbearing.
Audience: Well written for a wide audience, this book will be a useful reference for clinical practitioners in oncology and reproductive medicine, as well as scientists and embryologists who do not have direct patient contact. The authors are all leaders in the field, and many have participated in the creation and development of these technologies.
Features: The book covers the biology of cancer, the effects of treatment on the reproductive system and potential fertility-sparing options for men and women. One of the outstanding features of this book is the merging of oncology and reproduction so that people in both fields will benefit from reading it. The selected color images are useful and appropriate.
Assessment: This is a valuable addition to the current literature on fertility preservation. It is quite thorough and appropriate for a wide audience. This is very important as cancer treatment and reproductive medicine require a multidisciplinary approach.
From the Publisher
"...valuable addition to the current literature on fertility preservation...quite thorough and appropriate for a wide audience. This is very important as cancer treatment and reproductive medicine require a multidisciplinary approach." Doody's Review Service, Patricia T. Jimenez, MD, Washington University School of Medicine, St. Louis

There are few areas of the book that I can criticise. Indeed, I believe my review cannot do it justice: the expertise involved is so wide-ranging that no individual reviewer would have sufficient expertise to do so...all other aspects of fertility preservation are included. The text is easy to read and explanations for the uninitiated are careful and thorough. The editors have achieved the almost impossible: a textbook that is as informative as it is interesting. I would recommend it to anyone who treats illnesses that can affect fertility in both men and women." The Obstetrician & Gynaecologist (2012), Geoffrey Lane, MD, FRCOG, FFRSH, Guy's and St. Thomas' NHS Foundation Trust, London

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Product Details

  • ISBN-13: 9780521196956
  • Publisher: Cambridge University Press
  • Publication date: 2/3/2011
  • Pages: 536
  • Product dimensions: 7.50 (w) x 9.70 (h) x 1.30 (d)

Meet the Author

Jacques Donnez is Head of the Department of Gynecology and Andrology, Université Catholique de Louvain, Brussels, Belgium.

S. Samuel Kim is Director and Associate Professor of the Division of Reproductive Endocrinology at the University of Kansas, Kansas City, KS, USA.

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Table of Contents

Foreword; Preface; Part I. Introduction: 1. The evolution of ART; 2. The effect of chemotherapy and radiotherapy treatment for cancer on the reproductive system in humans; 3. Fertility preservation in non-cancer patients; Part II. Cancer Biology, Epidemiology and Treatment: 4. Basic cancer biology and immunology; 5. Breast cancer and fertility preservation: a view from oncology; 6. Breast cancer therapy and reproduction; 7. Pediatric cancer therapy and fertility; 8. Cancer epidemiology and environmental factors in children, adolescents and young adults; Part III. Reproductive Biology and Cryobiology: 9. Life and death in the germ line: apoptosis and the origins of DNA damage in human spermatozoa; 10. Molecular aspects of follicular development; 11. Fundamental cryobiology of reproductive cells and tissues: concepts and misconceptions; 12. Fundamental aspects of vitrification as a method of reproductive cell, tissue, and organ cryopreservation; Part IV. Fertility Preservation Strategies in the Male: 13. Hormonal suppression for fertility preservation in the male; 14. Cryopreservation of spermatozoa: old routine and new perspectives; 15. Transplantation of cryopreserved spermatogonia; 16. Fertility preservation strategies in males: cryopreservation and transplantation of testicular tissue; 17. Assisted reproductive techniques and donor sperm in cancer patients; Part V. Fertility Preservation Strategies in the Female: Medical/Surgical: 18. Use of GnRH agonists for prevention of chemotherapy-induced gonado-toxicity; 19. Ovarian transposition; 20. Fertility-saving surgery for cervical cancer; 21. Results of conservative management of ovarian malignant tumors; Part VI. Fertility Preservation Stategies in the Female: ART: 22. Embryo cryopreservation as a fertility preservation strategy; 23. Oocyte cryopreservation – slow freezing; 24. Cryopreservation of human oocytes and the evolution of vitrification technology for this purpose; 25. Cryopreservation and transplantation of isolated follicles; 26. ART and oocyte donation in cancer survivors; Part VII. Ovarian Cryopreservation and Transplantation: 27. General overview of ovarian cryobanking; 28. Ovarian tissue cryopreservation; 29. Ovarian tissue transplantation; 30. Whole ovary freezing; 31. Ovarian transplantation: whole ovary transplantation; Part VIII. In-Vitro Follicle Growth and Maturation: 32. Molecular and cellular integrity of cultured follicles; 33. In-vitro growth (IVG) systems for human oocytes: from primordial to maturation; 34. Contributions of ovarian stromal cells to follicle culture; 35. In-vitro maturation of GV oocytes; 36. Clinical potential of in-vitro maturation; Part IX. Future Technologies: 37. From pluripotent stem cells to germ cells; 38. Artificial ovary; 39. Predicting ovarian futures: the contribution of genetics; Part X. Ethical, Legal and Religious Issues with Fertility Preservation: 40. Psychological issues of cancer survivors; 41. Fertility preservation: ethical considerations; 42. Legal aspects of fertility preservation; 43. Christian ethics in fertility preservation; Index.

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