Principles and Practice of Skin Toxicology / Edition 1

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Written by authorities in the field, this book provides a "bottom up" approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

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Editorial Reviews

From the Publisher
"This is a very useful book for students or toxicologists who want to familiarize themselves with the specific subdiscipline of ermatoxicology, and with the currently validated methods of the trade. The fact that the book is easy to read with a logical story line makes it suitable for students." (BTS Newsletter, Summer 2009)
Doody's Review Service
Reviewer: Patricia Wong, MD (Stanford University Medical Center)
Description: This book will be useful for those who are interested in creating effective skin products and topical medications. The basic principles of cutaneous diffusion, absorption, oxidation, metabolism, and cellular entry are nicely covered. Factors which can enhance or decrease these parameters are discussed in detail. The methodology and instrumentation for studying these changes is explained, as are assays to quantify effects.
Purpose: The purpose is to aid researchers and those in the cosmeceutical industry in designing effective topical agents to achieve various goals: prevention of mitochondrial DNA damage, reduction of reactive oxygen species, increase hydration, provide barrier protection, and minimize phototoxicity in the skin.
Audience: The audience is scientists whose research focuses on the study and design of medications and products applied to skin.
Features: The authors discuss the cellular biology background first and then the applications of such knowledge in choosing appropriate delivery vehicles, pH, and chemicals to achieve specific therapeutic goals. How to measure water permeability, transepidermal electrical resistance, and partitioning of the product into the stratum corneum and dermal layer are extensively covered. The appendix has a list of the many abbreviations used throughout the book and numerous graphs, equations, and schematic diagrams illustrate what is discussed in the text.
Assessment: Researchers will find this book a handy reference. Those who are contemplating manufacturing their own skin care products should definitely read this book.
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Product Details

  • ISBN-13: 9780470511725
  • Publisher: Wiley
  • Publication date: 10/27/2008
  • Edition number: 1
  • Pages: 392
  • Product dimensions: 6.80 (w) x 9.80 (h) x 1.00 (d)

Table of Contents





List of contributors

PART I Introduction

1 Cutaneous anatomy and function

Robert P. Chilcott

1.1 Introduction and scope

1.2 Surface features

1.3 Functional histology of the epidermis and associatedstructures

1.4 Species differences



2 Biochemistry of the skin

Simon C. Wilkinson

2.1 Introduction and scope

2.2 Protein synthesis and organisation during epidermaldifferentiation

2.3 Lipid synthesis and organisation during epidermaldifferentiation

2.4 Lipid classes in the stratum corneum

2.5 Stratum corneum turnover

2.6 Biotransformations in skin



3 Skin photobiology

Mark A. Birch-Machin and Simon C. Wilkinson

3.1 Introduction and scope

3.2 Photoprotection and melanogenesis

3.3 Increased environmental ultraviolet radiation exposure andits link with photoageing and skin cancer

3.4 Mitochondrial DNA as a biomarker of sun exposure in humanskin

3.5 Apoptosis

3.6 Sun protection



PART II Skin Absorption

4 Skin as a route of entry

Simon C. Wilkinson

4.1 Salient anatomical features of the stratum corneum –the ‘brick and mortar model’

4.2 Species and regional variation in skin structure

4.3 Species and regional variation in skin permeability

4.4 Intra- and inter-individual variation in percutaneousabsorption

4.5 Effect of age on skin barrier function

4.6 Role of skin appendages

4.7 The in vitro skin sandwich model

4.8 Penetration of particles through appendages



5 Physicochemical Factors Affecting Skin Absorption

Keith R. Brain and Robert P. Chilcott

5.1 Introduction

5.2 Physicochemical properties

5.3 Exposure considerations



6 Principles of Diffusion and Thermodynamics

W. John Pugh and Robert P. Chilcott

6.1 Introduction and scope

6.2 Some definitions pertaining to skin absorptionkinetics 

6.3 Basic concepts of diffusion

6.4 Fick’s Laws of diffusion

6.5 Thermodynamic activity

6.6 Skin absorption of a substance from two differentvehicles

6.7 Partitioning

6.8 Diffusivity

6.9 Skin absorption data and risk assessments



7 In vivo measurements of skinabsorption

James C. Wakefield and Robert P. Chilcott

7.1 Introduction and scope

7.2 Why conduct in vivo studies?

7.3 Ethics and legislation

7.4 Standard methodology: OECD Guideline 427

7.5 Alternative in vivo methods



8 In vitro percutaneous absorptionmeasurements

Ruth U. Pendlington

8.1 Introduction and scope

8.2 Regulatory guidelines

8.3 Why assess percutaneous absorption in vitro?

8.4 Basic principle of in vitro percutaneous absorptionmeasurements

8.5 Choice of diffusion cell

8.6 Skin membrane considerations

8.7 Integrity measurements

8.8 Choice of receptor fluid and sampling considerations

8.9 Test material considerations

8.10 Application of test preparation to the skin

8.11 Examples of results from in vitro skin absorptionstudies

8.12 What is considered to be absorbed?

8.13 Micro-autoradiography



PART III Toxicological Assessment

9 Skin immunology and sensitisation

David A. Basketter

9.1 Introduction

9.2 Definitions

9.3 Skin sensitisation

9.4 Identification of skin sensitisers

9.5 Risk assessment

9.6 Other types of allergic skin reaction

9.7 Future prospects



10 In vitro phototoxicity assays

Penny Jones

10.1 Introduction and scope 

10.2 In vitro strategies for phototoxicity testing

10.3 The UV/visible absorption spectrum as a pre-screen forphototoxicity

10.4 In vitro assays for phototoxicity using monolayercultures

10.5 In vitro assays for photoallergenicity

10.6 In vitro assays for phototoxicity using human 3-Dskin models 



11 In vitro alternatives for irritationand corrosion assessment

Penny Jones

11.1 Introduction and scope

11.2 Acute dermal irritation/corrosion

11.3 Validation/regulatory status of in vitro assays forskin corrosion 

11.4 In vitro tests for skin corrosion

11.5 Validation/regulatory status of in vitro assays forskin irritation

11.6 In vitro tests for skin irritation



12 Instruments for measuring skin toxicity 

Helen Taylor

12.1 Introduction and scope

12.2 Skin surface pH

12.3 Biomechanical properties

12.4 Sebum

12.5 Skin surface contours

12.6 Thickness

12.7 Desquamation

12.8 Applications and measurement of transepidermal waterloss

12.9 Guidance for TEWL measurements 

12.10 Hydration measurement

12.11 Guidance for hydration measurements

12.12 Relationship between hydration and dermal toxicity

12.13 Colour measurement

12.14 Measurement of vascular perfusion

12.15 A final word of caution



PART IV Clinical Aspects 

13 Introduction to dermatology

Manjunatha Kalavala and Alex Anstey

13.1 Introduction and scope

13.2 Clinical assessment of patient with skin disease

13.3 Cutaneous manifestations of disease following exposure tochemicals and pharmaceutical formulations

13.4 Overview of standard treatments


14 Clinical aspects of phototoxicity

Anthony D. Pearse and Alex Anstey

14.1 Introduction and scope 

14.2 UV-induced skin reactions

14.3 Phototoxicity (photoirritancy) reactions

14.4 Photosensitive reactions



15 Occupational skin diseases

Jon Spiro

15.1 Introduction and scope

15.2 Dermatitis 

15.3 Development of occupational dermatitis 

15.4 Patterns of occupational dermatitis 

15.5 Incidence of occupational dermatitis

15.6 Effects of dermatitis on work

15.7 The outlook in occupational dermatitis

15.8 Identification of occupational dermatitis

15.9 Other occupational skin disorders

15.10 Investigation of a case of dermatitis at work



16 Prevention of occupational skin disease

Chris Packham

16.1 Prevention of occupational skin disease

16.2 Defining the problem

16.3 Material safety data sheets

16.4 Chain of responsibility

16.5 Managing dermal exposure

16.6 Selection and use of personal protective equipment

16.7 Protective or ‘barrier’ creams: do they have arole? 

16.8 The role of education and training

16.9 Conclusions



PART V Regulatory

17 Occupational skin exposures: legal aspects

Chris Packham

17.1 Introduction and scope

17.2 Brief overview of current United Kingdom legislation

17.3 The employer’s perspective

17.4 Hazard identification

17.5 Risk assessment

17.6 Gloves: a note of caution



18 Safety assessment of cosmetics: an EU perspective

Jo Larner

18.1 Introduction and scope

18.2 Overview and scope of Cosmetics Directive 76/768/EC

18.3 Overview of the requirements of the EU CosmeticsDirective

18.4 Scientific advice

18.5 Influence of other legislation

18.6 Adverse effects from cosmetics

18.7 Toxicity of cosmetic ingredients

18.8 The safety assessment

18.9 A final consideration



Appendix 18.1 Additional obligations for cosmetic suppliers

19 Regulatory dermatotoxicology and internationalguidelines

Adam Woolley

19.1 Introduction

19.2 Regulatory context

19.3 Product groups and the human context

19.4 Dermal toxicology with the different product groups

19.5 Factors in dermal toxicity

19.6 Repeat dose dermal toxicology

19.7 Classic short-term dermal toxicity studies

19.8 Pragmatic considerations



20 Glossary of main terms and abbreviations

James C. Wakefield


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