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From The CriticsReviewer: Patricia Wong, MD (Stanford University Medical Center)
Description: This book will be useful for those who are interested in creating effective skin products and topical medications. The basic principles of cutaneous diffusion, absorption, oxidation, metabolism, and cellular entry are nicely covered. Factors which can enhance or decrease these parameters are discussed in detail. The methodology and instrumentation for studying these changes is explained, as are assays to quantify effects.
Purpose: The purpose is to aid researchers and those in the cosmeceutical industry in designing effective topical agents to achieve various goals: prevention of mitochondrial DNA damage, reduction of reactive oxygen species, increase hydration, provide barrier protection, and minimize phototoxicity in the skin.
Audience: The audience is scientists whose research focuses on the study and design of medications and products applied to skin.
Features: The authors discuss the cellular biology background first and then the applications of such knowledge in choosing appropriate delivery vehicles, pH, and chemicals to achieve specific therapeutic goals. How to measure water permeability, transepidermal electrical resistance, and partitioning of the product into the stratum corneum and dermal layer are extensively covered. The appendix has a list of the many abbreviations used throughout the book and numerous graphs, equations, and schematic diagrams illustrate what is discussed in the text.
Assessment: Researchers will find this book a handy reference. Those who are contemplating manufacturing their own skin care products should definitely read this book.