Principles of Bio-Nanotechnolgy: Lessons from Nature / Edition 1

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Biological molecules are themselves the premier, proven examples of the feasibility and utility of nanotechnology in effect, "lessons from nature" informing the design of nanoscale machines. Bionanotechnology encompasses the study, creation, and illumination of the connections between structural molecular biology and molecular nanotechnology. The very first resource to address this discipline comprehensively and exclusively, Bionanotechnology: Lessons from Nature delivers an accessible overview that features a stunning set of original watercolor illustrations by the author. Bionanotechnology: Lessons from Nature shows both students and practitioners how the lessons that may be learned from biology can be applied to nanotechnology today. The first part of the book explores the properties of nanomachines that are available in cells. The second looks to the structure and function of natural nanomachines for guidance in building nanomachinery. The book then concludes with chapters on applications, surveying some of the exciting bionanotechnological tools and techniques that are currently in development, and speculating on those that may prove feasible in the not-too-distant future. Features of this one-of-a-kind reference include: High-quality illustrations produced by cutting-edge design programs Discussions of basic structural, nanotechnological, and system engineering principles Numerous real-world examples, such as applications in genetic engineering Undergraduates, graduate students, practicing researchers, and policymakers will find David Goodsell's Bionanotechnology an accessible, visually compelling introduction to this exciting field.

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Editorial Reviews

From the Publisher
“…a stimulating volume…borrow it from yourlibrary…” (Journal of Chemical Technology andBiotechnology, Vol. 80 (8), August 2005)

"…Goodsell's book is a good start." (Yale Journal ofBiology and Medicine, May 2005) 

"David S. Goodsell's new book is a useful introduction tobionanotechnology…" (NanoToday, May 2005)

“This is a stimulating volume …borrow it from yourlibrary.”  (Journal of Chemical Technology andBiotechnology, 2005; Vol. 80, 964-965)

“…concludes with chapters on applications, surveyingsome of the exciting bionanotechnology tools and techniques thatare currently in development…” (CAB Abstracts,2005)

"…will quickly bring intelligent readers up to speed onthe most important aspects...I enthusiastically recommend thistimely and well-written book on this important, emerging field."(The Quarterly Review of Biology, December 2004)

"…a wonderful introductory text for those who want tounderstand nanotechnology from a biological perspective…anoutstanding work for the educated novice as well as for theseasoned nanotechnologist." (ASM News, October 2004)

"…this book appears to be one of the only overview textsavailable.” (E-STREAMS, September 2004)

" window into the nanoworld...highly readable...will notonly educate students but also reach a wider audience..."(Chemistry World, August 2004)

"Goodsell's fresh perspective on nanotechnology and persuasivearguments about the future of bionanotechnology have certainly mademe into a believer—Bionanotechnology is going to be big!"(Biotechnology Focus, July 2004)

"Bionanotechnology: Lessons from Nature is well writtenand informative.  That alone would make it a good read forchemists. But there's a bonus: The book is full of Goodsell'sunique illustrations of biomolecules and cells." (C&EN,June 14, 2004)

"Written in the style of an excellent biochemistry textbook,Bionanotechnology points the reader to  generalprinciples of the biological nanoworld, and thus provides readerswith guidance on the design of their own devices andsystems…. I can highly recommend this book. I enjoyed readingevery single page" (Nature, July 2004)

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Product Details

  • ISBN-13: 9780471417194
  • Publisher: Wiley
  • Publication date: 9/28/2003
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 350
  • Product dimensions: 7.85 (w) x 9.19 (h) x 0.91 (d)

Table of Contents

1. The Quest for Nanotechnology.

Biotechnology and the Two-Week Revolution.

From Biotechnology to Bionanotechnology.

What is Bionanotechnology?

2. Bionanomachines in Action.

The Unfamiliar World of Bionanomachines.

Gravity and Inertia are Negligible at the Nanoscale.

Nanomachines Show Atomic Granularity.

Thermal Motion is a Significant Force at the Nanoscale.

Bionanomachines Require a Water Environment.

Modern Biomaterials.

Most Natural Bionanomachines are Composed of Protein.

Nucleic Acids Carry Information.

Lipids are Used for Infrastructure.

Polysaccharides are Used in Specialized Structural Roles.

The Legacy of Evolution.

Evolution has Placed Significant Limitations on the Propertiesof Natural Biomolecules.

Guided Tours of Natural Bionanomachinery.

3. Biomolecular Design and Biotechnology.

Recombinant DNA Technology.

DNA may be Engineered with Commercially Available Enzymes.

Site-Directed Mutagenesis makes Specific Changes in theGenome.

Fusion Proteins Combine Two Functions.

Monoclonal Antibodies.

Biomolecular Structure Determination.

X-ray Crystallography Provides Atomic Structures.

NMR Spectroscopy may be Used to Derive Atomic Structures.

Electron Microscopy Reveals Molecular Morphology.

Atomic Force Microscopy Probes the Surface of Biomolecules.

Molecular Modeling.

Bionanomachines are Visualized with Computer Graphics.

Computer Modeling is Used to Predict Biomolecular Structure andFunction.

The Protein Folding Problem.

Docking Simulations Predict the Modes of BiomolecularInteraction.

New Functionalities are Developed with Computer-AssistedMolecular Design.

4. Structural Principles of Bionanotechnology.

Natural Bionanomachinery is Designed for a SpecificEnvironment.

A Hierarchical Strategy Allows Construction of Nanomachines.

The Raw Materials: Biomolecular Structure and Stability.

Molecules are Composed of Atoms Linked by Covalent Bonds.

Dispersion and Repulsion Forces Act at Close Range.

Hydrogen Bonds Provide Stability and Specificity.

Electrostatic Interactions are Formed Between Charged Atoms.

The Hydrophobic Effect Stabilizes Biomolecules in Water.

Protein Folding.

Not All Protein Sequences Adopt Stable Structures.

Globular Proteins have a Hierarchical Structure.

Stable Globular Structure Requires a Combination of DesignStrategies.

Chaperones Provide the Optimal Environment for Folding.

Rigidity Can Make Proteins More Stable at High Temperatures.

Many Proteins Make Use of Disorder.


Symmetry Allows Self-Assembly of Stable Complexes with DefinedSize.

Quasisymmetry is Used to Build Assemblies too Large for PerfectSymmetry.

Crowded Conditions Promote Self-Assembly.


Lipids Self-Organize into Bilayers.

Lipid Bilayers are Fluid.

Proteins May be Designed to Self-Organize with LipidBilayers.

Molecular Recognition.

Crane Principles for Molecular Recognition.

Atomicity Limits the Tolerance of Combining Sites.


Biomolecules Show Flexibility at All Levels.

Flexibility Poses Great Challenges for the Design ofBionanomachines.

5. Functional Principles of Bionanotechnology.

Information-Driven Nanoassembly.

Nucleic Acids Carry Genetic Information.

Ribosomes Construct Proteins.

Information is Stored in Very Compact Form.


Chemical Energy is Transferred by Carrier Molecules.

Light is Captured with Specialized Small Molecules.

Protein Pathways Transfer Single Electrons.

Electrical Conduction and Change Transfer have Been Observed inDNA.

Electrochemical Gradients are Created across Membranes.

Chemical Transformation.

Enzymes Reduce the Entropy of a Chemical Reaction.

Enzymes Create Environments that Stabilize TransitionStates.

Enzymes Use Chemical Tools to Perform a Reaction.


Protein Activity May be Regulated through AllostericMotions.

Protein Action May be Regulated by Covalent Modification.


Helical Assembly of Subunits Forms Filaments and Fibrils.

Microscale Infractures is Built from Fibrous Components.

Minerals are Combined with Biomaterials for SpecialApplications.

Elastic Proteins Use Disordered Chains.

Cells Make Specific and General Adhesives.

Biomolecular Motors.

ATP Powers Linear Motors.

ATP Synthase and Flagellar Motors are Rotary Motors.

Brownian Ratchets Rectify Random Thermal Motions.

Traffic Across Membranes.

Potassium Channels Use a Selectivity Filter.

ABC Transporters Use a Flip-Flop Mechanism.

Bacteriorhodopsin Uses Light to Pump Protons.

Biomolecular Sensing.

Smell and Taste Detect Specific Molecules.

Light is Sensed by Monitoring Light-Sensitive Motions inRetinal.

Mechanosensory Receptors Sense Motion Across a Membrane.

Bacteria Sense Chemical Gradients by Rectification of RandomMotion.


Cells are Autonomous Self-Replicators.

The Basic Design of Cells is Shaped by the Processes ofEvolution.

Machine-Phase Bionanotechnology.

Muscle Sarcomeres.


6. Bionanotechnology Today.

Basic Capabilities.

Natural Proteins May be Simplified.

Proteins are Being Designed from Scratch.

Proteins May be Constructed with Nonnatural Amino Acids.

Peptide Nucleic Acids Provide a Stable Alternative to DNA andRNA.

Nanomedicine Today.

Computer-Aided Drug has Produced Effective Anti-AIDS Drugs.

Immunotoxins are Targeted Cell Killers.

Drugs May be Delivered with Liposomes.

Artificial Blood Saves Lives.

Gene Therapy will Correct Genetic Defects.

General Medicine is Changing into Personalized Medicine.

Self-Assembly at Many Scales.

Self-Assembling DNA Scaffolds have Been Constructed.

Cyclic Peptides Form Nanotubes.

Fusion Proteins Self-Assemble into Extended Structures.

Small Organic Molecules Self-Assemble into LargeStructures.

Larger Objects May be Self-Assembled.

Harnessing Molecular Motors.

ATP Synthase is Used as a Rotary Motor.

Molecular Machines have Been Built of DNA.

DNA Computers.

The First DNA Computer Solved a Traveling Salesman Problem.

Satisfiability Problems are Solved by DNA Computing.

A Turning Machine has Been Built with DNA.

Molecular Design Using Biological Selection.

Antibodies May be Turned into Enzymes.

Peptides May be Screened with Bacteriophage DisplayLibraries.

Nucleic Acids with Novel Functions May be Selected.

Functional Bionanomachines are Surprisingly Common.

Artificial Life.

Artificial Protocells Reproduce by Budding.

Self-Replicating Molecules are in Elusive Goal.

ATP is Made with  an Artificial PhotosyntheticLiposome.

Poliovirus has Been Created with Only a GeneticBlueprint.

Hybrid Materials.

Nanoscale Conductive Metal Wires May be Constructed withDNA.

 Patterned Aggregates of Gold Nanoparticles are Formed withDNA.

DNA Flexes a Sensitive Mechanical Lever.

Researchers are Harnessing Biomineralization.


Antibodies are Widely Used as Biosensors.

Biosensors Detect Glucose Levels for Management of Diabetes.

Engineered Nanopores Detect Specific DNA Sequences.

7. The Future of Bionanotechnology.

A Timetable for Bionanotechnology.

Lessons for Molecular Nanotechnology.

Three Case Studies.

Case Study: Nanotube Synthase.

Case Study: A General Nanoscale Assembler.

Case Study: Nanosurveillance.

Ethical Considerations.

Respect for Life.

Potential Dangers.

Final Thoughts.




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