Principles of Bone Biology

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Overview

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the ...
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Overview

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.

Author Biography: John P. Bilezikian, Columbia University, New York, U.S.A.
Lawrence G. Raisz, University of Connecticut, Farmington, U.S.A.
Gideon A. Rodan, Merck Research Labs, West Point, Pennsylvania, U.S.A.

Audience: This book is designed for endocrinologists, bone and mineral researchers, nephrologists, molecular/cellular biologists, and developmental biologists.

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Editorial Reviews

Bart L. Clarke
This is the first edition of an excellent monograph summarizing the major recent advances occurring in the field of bone biology. The book covers four areas: basic principles of bone biology; molecular mechanisms of metabolic bone disease; pharmacologic mechanisms of therapeutics; and methods in bone research. The book attempts to provide a new repository of knowledge concerning the revolution in bone biology. This is certainly a worthy objective, because there is a large volume of new basic information in the field. The book meets the editors' main objective very well. The intended audience is students, postdoctoral fellows, young investigators, and established scientists in the field of bone biology. A wider secondary audience will be clinicians caring for patients with metabolic bone disorders who desire to develop a deeper understanding of their patients' diseases. The editors are individually very credible authorities in this field, with many of the contributing authors internationally recognized experts in their own areas. The book is clearly and appropriately illustrated with black-and-white drawings and photographs and color prints. References are current and pertinent. The table of contents is very well organized, and the index provides sufficient detail to help the reader find almost any topic covered in the book. The book has a somewhat bland gray cover. An attractive feature of the book is the fairly liberal use of color plates to demonstrate points related to bone histomorphometry and skeletal details in various animal knockout models. This monograph will be useful to both new and accomplished students of bone biology, and to some degree, to the practicing clinicianwith an interest in metabolic bone disease. It fills a major void not occupied by several other recently published textbooks in the field, and it is likely to become the standard against which future textbooks in this field will be compared. The book will likely be purchased by medical libraries, medical bookstores, and scientists and clinicians interested in bone biology.
From The Critics
Reviewer: Bart L. Clarke, MD (Mayo Clinic)
Description: This is the first edition of an excellent monograph summarizing the major recent advances occurring in the field of bone biology. The book covers four areas: basic principles of bone biology; molecular mechanisms of metabolic bone disease; pharmacologic mechanisms of therapeutics; and methods in bone research.
Purpose: The book attempts to provide a new repository of knowledge concerning the revolution in bone biology. This is certainly a worthy objective, because there is a large volume of new basic information in the field. The book meets the editors' main objective very well.
Audience: The intended audience is students, postdoctoral fellows, young investigators, and established scientists in the field of bone biology. A wider secondary audience will be clinicians caring for patients with metabolic bone disorders who desire to develop a deeper understanding of their patients' diseases. The editors are individually very credible authorities in this field, with many of the contributing authors internationally recognized experts in their own areas.
Features: The book is clearly and appropriately illustrated with black-and-white drawings and photographs and color prints. References are current and pertinent. The table of contents is very well organized, and the index provides sufficient detail to help the reader find almost any topic covered in the book. The book has a somewhat bland gray cover. An attractive feature of the book is the fairly liberal use of color plates to demonstrate points related to bone histomorphometry and skeletal details in various animal knockout models.
Assessment: This monograph will be useful to both new and accomplished students of bone biology, and to some degree, to the practicing clinician with an interest in metabolic bone disease. It fills a major void not occupied by several other recently published textbooks in the field, and it is likely to become the standard against which future textbooks in this field will be compared. The book will likely be purchased by medical libraries, medical bookstores, and scientists and clinicians interested in bone biology.
From The Critics
Why a second edition now (the first in 1996)? Because, its editors assert, "Advances in bone biology over the past five years have moved forward at a dizzying pace." Examples of such advance are the elucidation of the molecular interactions between osteoblasts and osteoclasts, and animal studies in which critical genes have disappeared or been over-expressed. The second edition's articles have been revised and 10 new ones added. The 96 chapters are distributed among four parts: part one examines the basic principles of cell biology, biochemistry, the hormones of bone, other systemic hormones influencing bone metabolism, and local regulators. Part two concerns molecular mechanisms of metabolic bone diseases; part three, pharmacological mechanism of therapeutics; and four, methods in bone research. Extensively indexed. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Booknews
The first 53 chapters cover the cells themselves<-->the osteoblast, the osteoclast, and the osteocyte<-->and also covers the biochemistry of collagenous and noncollagenous bone proteins. A second section includes 17 chapters specifically devoted to basic mechanisms of a variety of bone diseases. In the third section, 12 chapters address the advances that have been made in elucidating how old and new drugs act to improve abnormalities in bone metabolism. The 15 chapters in the last section recognize the revolution in investigative methodologies and describe the clinical relevance of bone densitometry and bone biopsies. Annotation c. by Book News, Inc., Portland, Or.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780123738851
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 1/1/2008
  • Edition number: 3
  • Pages: 1942

Meet the Author

Dr. Bilezikian, Professor of Medicine and Pharmacology at the College of Physicians and Surgeons, Columbia University is the Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia-Presbyterian Medical Center. He also serves as Associate Chair, Department of Medicine.

Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians and Surgeons. He completed four years of house staff training (internship and residency) including the Chief Medical Residency of the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH where he served as a Clinical Associate in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach.

Dr. Bilezikian belongs to a number of professional societies, including the American Society for Bone and Mineral Research, of which he served as President in 1996. He is a member of the Endocrine Society, the American Federation for Clinical Research, the American Society for Clinical Investigation, the Association of American Physicians, the American Association of Clinical Endocrinologists, the American Society for Pharmacology and Experimental Therapeutics, and the International Society of Clinical Densitometry, of which he is President.

He is Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism. His books include Editor-in-Chief of The Parathyroids (1994), and co-editor of Principles of Bone Biology (1996), The Aging Skeleton (1999), and Dynamics of Bone and Cartilage Metabolism (1999). He has been on numerous panels, including serving as Chair of the NIH Consensus Development Panel on Optimal Calcium Intake, and the Food and Nutrition Board of the National Academy of Sciences. He is a major national and international spokesperson for the field of metabolic bone diseases. Dr. Bilezikian's major research inte

Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.

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Read an Excerpt

The most current and timely source of information about the biology and pathobiology of bone.
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Table of Contents

PART I: BASIC PRINCIPLES

Cell Biology
The Structure & Development of the Skeleton.
Biomechanics of Bone.
Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation.
Mesenchymal Stem Cells & Osteoblast Lineage.
Transcriptional Control of Osteoblast Differentiation and Function.
The Osteocyte.
Cells of Bone: Osteoclast Generation.
Osteoclast Function.
Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts.
Apoptosis in Bone Cells.
Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells.

Biochemistry
Type I Collagen: Structure, Synthesis, and Regulation.
Collagen Crosslinking & Metabolism.
Bone Matrix Proteoglycans & Glycoproteins.
Osteopontin.
Bone Proteinases.
Cell Surface Attachment Molecules.
Intercellular Junctions and Cell-Cell Communication in Bone.

Bone Remodeling and Mineral Homeostasis
Histomorphometric Analysis of Bone Remodeling.
Phosphorus Homeostasis & Related Disorders.
Magnesium Homeostasis.
Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium.
The Biology of the Extracellular Ca2+-Sensing Receptor (CaR).

The Hormones of Bone
Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide.
Parathyroid Hormone - Molecular Biology.
Parathyroid Hormone-Receptor Interactions.
Actions of Parathyroid Hormone.
Renal and Skeletal Actions of PTH and PTHrP.
Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues.
Vascular, Cardiovascular and Neurological Actions of PTHrP.
Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses.
Vitamin D Gene Regulation.
Photobiology and Non-Calcemic Actions of Vitamin D.
The Structure and Molecular Biology of the Calcitonin Receptor.
Physiology & Pathophysiology of Calcitonin.
Amylin & CGRP.

Other Systemic Hormones That Influence Bone Metabolism
Estrogens & Progestins.
Selective Estrogen Receptor Modulators (SERMs).
Mechanisms of Estrogen Action in Bone.
Thyroid Hormone & Bone.
Clinical and Basic Aspects of Glucocorticoid Action in Bone.
Effects of Diabetes & Insulin on Bone Physiology.
Androgens: Receptor Expression and Steroid Action in Bone.
Kinins & Neuro-Osteogenic Factors.

Local Regulators
The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology.
Platelet-Derived Growth Factor & the Skeleton.
Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone.
Vascular Endothelial Growth Factors.
Transforming Growth Factor (beta).
Bone Morphogenetic Proteins.
Bone Morphogenetic Protein Receptors & Actions.
Colony-Stimulating Factors.
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines.
Prostaglandins & Bone Metabolism.
Nitric Oxide and other Vasoactive Agents.

PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES

Molecular Basis of PTH Overexpression.
Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism.
Multiple Endocrine Neoplasia Type I.
The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2.
Systemic Factors in Skeletal Manifestations of Malignancy.
Local Factors in Skeletal Malignancy.
Molecular Basis of PTH Underexpression.
Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations.
Signal Transduction via G Proteins; Pseudohypoparathyroidism.
Other Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright Syndrome.
Osteogenesis Imperfecta.
Hereditary Deficiencies in Vitamin D Action.
Oncogenic Osteomalacia.
Osteopetrosis.
Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man.
Paget's Disease of Bone.
Genetic Determinants of Bone Mass.
Pathophysiology of Osteoporosis.
Evaluation of Risk for Osteoporosis Fractures.

PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS

Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone.
Calcium.
Calcium Receptors as Novel Drug Targets.
Bisphosphonates: Mechanisms of Action.
Fluoride in Osteoporosis.
The Pharmacology of Estrogens in Osteoporosis.
Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs.
Molecular and Clinical Pharmacology of Calcitonin.
Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases.
Anabolic Steroid Effects on Bone in Women.
Estrogen Effects on Bone in the Male Skeleton.
Mechanisms of Exercise Effects on Bone.

PART IV: METHODS IN BONE RESEARCH

Application of Transgenic Mice to Problems of Skeletal Bone.
Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes.
Current Methodologic Issues in Cell & Tissue Culture.
Biochemical Markers of Bone Metabolism.
Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry.
Controversies in Bone Mass Measurement.
Macro and Micro Imaging of Bone Architecture.
Transilial Bone Biopsy.
Animal Models in Osteoporosis Research.
Defining the Genetics of Osteoporosis - Using the Mouse to Understand Man.
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