Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

*Provides a “one-stop” shop. There is no need to search through many ...
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Principles of Bone Biology: Two-Volume Set

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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

*Provides a “one-stop” shop. There is no need to search through many research journals or books to glean the information one wants…it is all in one source written by the experts in the field.

*THE essential resource for anyone involved in the study of bones and bone diseases.

*Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.

*Readers can easily search and locate information quickly as it will be online with this new edition.
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Editorial Reviews

From the Publisher
"Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently."
-The New England Journal of Medicine
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Product Details

  • ISBN-13: 9780080568751
  • Publisher: Elsevier Science
  • Publication date: 9/29/2008
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 3
  • Pages: 1900
  • File size: 23 MB
  • Note: This product may take a few minutes to download.

Meet the Author

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians&Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians&Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.
Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.
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Table of Contents

Part I
Basic Principles

A. Cell Biology

Chapter 1:
Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity
Ego Seeman

Chapter 2:
Biomechanics of Bone
Elise Morgan

Chapter 3:
Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
Andrew Karaplis

Chapter 4:
Mesenchymal Stem Cells&Osteoblast Lineage
Jane Aubin

Chapter 5:
Transcriptional Control of Osteoblast Differentiation and Function
Thorsten Schinke

Chapter 6:
Wnt Signaling and Bone
Mark Johnson

Chapter 7:
Sclerostin and Bone
Rutger van Bezooijen

Chapter 8:
The Osteocyte
Jenneke Klein-Nulend

Chapter 9:
Cells of Bone: Osteoplast Generation
Tatsuo Suda

Chapter 10:
Osteoclast Function: Biology and Mechanisms
Kalervo Vaananen

Chapter 11:
RANK Signaling
Hiroshi Takanayagi

Regulating Bone Resorption
Roland Baron

Chapter 13:
Apoptosis in Bone Cells
Stavros Manolagas

Chapter 14:
Skeletal Gene Expression in Nuclear Microenvironments
Gary Stein

B. Biochemistry

Chapter 15:
Type I Collagen: Structure, Synthesis, and Regulation
Benoit de Crombrugghe

Chapter 16:
Collagen Crosslinking&Metabolism
Simon Robins

Chapter 17:
Bone Matrix Proteoglycans&Glycoproteins
Pamela Robey

Chapter 18:
Masaki Noda

Chapter 19:
Bone Proteinases
Nicola Partridge

Chapter 20:
Integrins and Other Cell Surface Attachment Molecules of Bone Cells
Michael Horton

Chapter 21:
Intercellular Junctions and Cell-Cell Communication in the Skeletal System
Roberto Civitelli

C. Bone Remodeling and Mineral Homeostasis

Chapter 22:
Histomorphometric Analysis of Bone Remodeling
David Dempster

Chapter 23:
Phosphorus Homeostasis&Related Disorders
Marc Drezner

Chapter 24:
Magnesium Homeostasis
Robert Rude

Chapter 25:
Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon,&Stro
Felix Bronner

Chapter 26:
Biology of the Extracellular Ca2+-Sensing Receptor
Edward Brown

D. The Hormones of Bone

Chapter 27:
Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein
John Potts

Chapter 28:
Parathyroid Hormone - Molecular Biology
Hank Kronenberg

Chapter 29:
Parathyroid Hormone-Receptor Interactions
Mike Rosenblatt

Chapter 30:
Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System
John Bilezikian

Chapter 31:
The Vascular and Cardiovascular Actions of PTH
John Bilezikian

Chapter 32:
PTH and PTHrP Actions on Kidney and Bone
Peter Friedman

Chapter 33:
Physiological Actions of Parathyroid Hormone and PTH-Related Protein
John Wysolmerski

Chapter 34:
Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein
Thomas Clemens

Chapter 35:
Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses
Tony Norman

Chapter 36:
Vitamin D Gene Regulation
Sylvia Christakos

Chapter 37:
Photobiology and Non-Calcemic Actions of Vitamin D
Mike Holick

Chapter 38:
Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects
Bob Gagel

Chapter 39:
Amylin and Calcitonin Gene-Related Peptide
Jill Cornish

E. Other Systemic Hormones That Influence Bone Metabolism

Chapter 40:
Russell Turner

Chapter 41:
The Pharmacology of Selective Estrogen Receptor Modulators
Henry Bryant

Chapter 42:
Mechanisms of Estrogen Action in Bone
Roberto Pacifici

Chapter 43:
Thyroid Hormone&Bone
Paula Stern

Chapter 44:
Clinical and Basic Aspects of Glucocorticoid Action in Bone
Barbara Kream

Chapter 45:
Effects of Diabetetes&Insulin on Bone Physiology
Johan Verhaeghe

Chapter 46:
Androgens:Receptor Expression and Steroid Action in Bone
Kristine Wiren

Chapter 47:
Kinins&Neuro-Osteogenic Factors
Ulf Lerner

Chapter 48:
Regulation of Bone Remodeling by Central and Peripheral Nervous Signals
Patricia Ducy

F. Local Regulators

Chapter 49:
Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology
Cliff Rosen

Chapter 50:
Platelet-Derived Growth Factor&the Skeleton
Ernesto Canalis

Chapter 51:
Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone
Marja Hurley

Chapter 52:
Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling
Dwight Towler

Chapter 53:
Transforming Growth Factor-â
Sarah Dallas

Chapter 54:
Bone Morphogenetic Proteins and the Skeleton
Vicki Rosen

Chapter 55:
Bone Morphogenetic Protein Receptors&Actions
Kohei Miyazono

Chapter 56:
Colony-Stimulating Factor-1
Willy Hofstetter

Chapter 57:
Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
Mark Horowitz

Chapter 58:
Prostaglandins&Bone Metabolism
Carol Pilbeam

Part II
Molecular Mechanisms of Metabolic Bone Disease

Chapter 59:
Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis
Sunil Wimalawansa

Chapter 60:
Molecular Basis of PTH Overexpression
Andy Arnold

Chapter 61:
Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism
Ghada EI-Hajj Fuleihan

Chapter 62:
Multiple Endocrine Neoplasia Type I
Maria Luisa Brandi

Chapter 63:
Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy
David Goltzman

Chapter 64:
Local Factors in Skeletal Malignancy
Greg Mundy

Chapter 65:
Genetic Regulation of the Parathyroid Gland Development
Raj Thakker

Chapter 66:
Jansen's Metaphyseal Chondrodysplasia&Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations
Harald Jueppner

Chapter 67:
Diseases Resulting from Defects in the G Protein Gs
Lee Weinstein

Chapter 68:
Renal Osteodystrophy – Pathogenic Mechanisms and Therapeutic Options
Bill Goodman

Chapter 69:
Osteogenesis Imperfecta
David Rowe

Chapter 70:
Hereditary Deficiencies in Vitamin D Action
Uri Liberman

Chapter 71:
Oncogenic Osteomalacia
Suzanne Jan de Beur

Chapter 72:
Lyndon Key

Chapter 73:
Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans
Michael Whyte

Chapter 74:
Paget's Disease of Bone
Fred Singer

Chapter 75:
Genetic Determinants of Bone Mass and Osteoporotic Fracture
Stuart Ralston

Chapter 76:
Pathophysiology of Osteoporosis
Bilezikian, Raisz, Martin

Chapter 77:
Evaluation of Risk for Osteoporosis Fracture
Stuart Silverman

Part III
Pharmacological Mechanisms of Therapeutics

Chapter 78:
Parathyroid Hormone
Dave Hanley

Chapter 79:
Robert Heaney

Chapter 80:
Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics
Edward Nemeth

Chapter 81:
Bisphosphonates: Mechanisms of Action
Graham Russell

Chapter 82:
The Pharmacology of Estrogens in Osteoporosis
Robert Lindsay

Chapter 83:
Vitamin D&Analogs
Glenville Jones

Chapter 84:
Estrogen Effects on Bone in the Male Skeleton
Luigi Gennari

Chapter 85:
Mechanisms of Exercise Effects on Bone Quantity and Quality
Clint Rubin

Part IV
Methods in Bone Research

Chapter 86:
Application of Transgenic Mice to Problems of Skeletal Bone
Stephen Clark

Chapter 87:
Biochemical Markers of Bone Metabolism
Markus Seibel

Chapter 88:
Methods and Clinical Issues in Bone Densitometry
Glen Blake

Chapter 89:
Controversial Issues in Bone Densitometry
Paul Miller

Chapter 90:
Macro and Micro Imaging of Bone Architecture
Klaus Engelke, Sven Prevrhal, and Harry K. Genant
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  • Posted October 27, 2009

    more from this reviewer

    Text Book Review

    Textbook: Principles of Bone Biology
    Editors: John Bilezikian, Lawrence Raisz, John Martin
    Published: 2008 (3rd Edition)
    Organization: Two volumes 1942 pages consisting of 4 major parts and 90 chapters

    Principles of Bone Biology is a comprehensive text which includes in-depth analysis of topics ranging from basic cell biology and biochemistry, the complex interactions of bone hemostasis, principals behind metabolic bone diseases including their treatment, and research methods. The list of chapter authors includes many of the most prominent and well published names in the field. As the third edition (previous edition was published in 2002) the chapters have been extensively updated especially in the therapeutics portion.

    The four major sections are 1) Basic Principles 2) Molecular Mechanisms of Metabolic Bone Disease 3)Pharmacological Mechanisms of Therapeutics and 4) Methods in Bone Research. Each section is broken up into subsections that follow a logical order and each chapter is about 15 to 25 pages in length. There is extensive use of graphs, tables and pictures (black and white) that help organize and summarize the content as well as references. Many of the chapters conclude with the authors's remarks and/ or future direction which helpful to the reader to obtain the salient points or understand where the future growth in this field will be.

    Principles of Bone Biology is an excellent reference source on a topic that receives relatively little coverage in the standard internal medicine or orthopedic textbooks. The extensive breath and depth contained in this textbook makes it a valuable resource for those who do research in this area as a way to obtain succinct information and background for their own research. For practitioners who have a focus in treating patients with metabolic bone disease this text can provide greater background on the basics of bone biology as well as the basis of treatment. Finally, this book would be an excellent addition to any medical library as an excellent go to book for any question on bone biology.


    Eric Owen Eisemon, M.D.

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