Principles of Cloning

Principles of Cloning

by Jose Cibelli
     
 

ISBN-10: 012174597X

ISBN-13: 9780121745974

Pub. Date: 08/23/2002

Publisher: Elsevier Science

Principles of Cloning is the first comprehensive book on animal cloning since the creation of Dolly. The contributing authors are the principal investigators on each of the animal species cloned to date, and are expertly qualified to present the state-of-the-art information in their respective areas. Editors Cibelli, Lanza and West garnered worldwide

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Overview

Principles of Cloning is the first comprehensive book on animal cloning since the creation of Dolly. The contributing authors are the principal investigators on each of the animal species cloned to date, and are expertly qualified to present the state-of-the-art information in their respective areas. Editors Cibelli, Lanza and West garnered worldwide spotlight late in 2001 when their company, Advanced Cell Technology, announced the successful engineering of the world's first cloned human embryo. The trio was featured in the US News & World Report December 2001 cover story, "The First Human Clone." The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine.

Key Features
• First and most comprehensive book on animal cloning
• Chapters written by the world' expert in each area
• From the early experiments in amphibia to the latest one in mammals, everything is included in this book and told by the researcher that did it and how they did it
• Basic biological mechanisms on how cloning works and all their current and potential applications
• Cloning applications on basic biology, agriculture, biotechnology and medicine are included
• Editors are the pioneers in the field

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Product Details

ISBN-13:
9780121745974
Publisher:
Elsevier Science
Publication date:
08/23/2002
Pages:
531
Product dimensions:
11.00(w) x 8.50(h) x 1.19(d)

Table of Contents

List of Contributors.
Preface.
Introduction.
Historical Perspective.

PART ONE-BASIC BIOLOGICAL PROCESES
Activation of Mammalian Oocytes.
The Nucleus.
Nuclear Reprogramming: Biological and Technological Constraints.
Plasticity of somatic nucleus by epigenetic reprogramming via cell Hybridization.
Cell Cycle.
Determinants of Pluripotency in Mammals.
Cloning and Aging.

PART TWO-METHODS
Micromanipulation Techniques for Cloning.
Microinsemination and Nuclear Transfer with Male Germ Cells.
Development of viable mammalian embryos in vitro: Evolution of sequential media.
Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets.
Genetic Modification and Cloning in Mammals.
Pregnancy and Neonatal Care of Clone Animals.
Donor Cell Type and Cloning Efficiency in Mammals.

PART THREE-CLONING BY SPECIES
The Cloning of Amphibians.
Cloning of Fish.
Cloning of Mice.
Cloning of Rabbits.
Nuclear Transfer in Swine.
Cloning of Cattle.
Cloning of Sheep.
Cloning of Goats.

PART FOUR-CURRENTLY SOUGHT AFTER SPECIES
Cloning of Endangered Species.
Cloning of Rats.

PART FIVE-NUCLEAR TRANSFER IN PRIMATES
Cloning in Non-Human Primates.

PART SIX-APPLICATIONS
Nuclear Transfer for Stem Cells (CRNT).
Current Research and Commercial Applications of Cloning Technology.
Transgenic Cloned Goats and the Production of Therapeutic Proteins.

PART SEVEN-ETHICAL AND LEGAL AFFAIRS
Ethical Implications of Cloning.

FINAL REMARKS
Mammalian Cloning- Challenges for the Future.

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