Principles of Molecular Cardiology / Edition 1

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Overview

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

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Editorial Reviews

From The Critics
Reviewer: Keith G Hickey, MD, BS (Ochsner Clinic Foundation)
Description: This book explores the latest developments in molecular cardiology research covering the molecular basis of cardiovascular diseases.
Purpose: The purpose is to discuss the molecular biology of cardiovascular diseases. This book provides overviews of the major themes in molecular cardiology, including cardiac function, coronary artery disease, arrhythmias, vascular diseases and risk factors. The authors make these complex topics easy to understand.
Audience: This book is intended for clinicians, scientists, students, and healthcare professionals who want to keep abreast of current findings in molecular cardiology research. The authors are all leading specialists in their fields.
Features: The book is divided into six sections, which are subdivided into chapters, beginning with a historical overview of the major themes in molecular cardiology: genetics, the molecular biology of the cardiovascular system, genomics and gene therapy and stem cells in cardiovascular disease. The next part covers cardiac function and dysfunction, including inherited diseases such as hypertrophic cardiomyopathies and muscular dystrophies that affect the heart. Part three addresses coronary artery disease. Section four on cardiac arrhythmias is timely given the recent progress in understanding the molecular basis and genetics of ventricular arrhythmias and sudden death. This is followed by a section on vascular diseases, which contains state-of-the art chapters on the molecular events that regulate angiogenesis. The book concludes with an excellent section on risk factors, summarizing the molecular basis of lipid metabolism, the biology of aging and the consequences of diabetes. Throughout each section several chapters are dedicated to treatment strategies which clinicians will find relevant. These chapters have excellent tables, photomicrographs, and figures that help illustrate concepts and aid understanding of the text.
Assessment: The authors have written a unique book that examines the latest developments in molecular cardiology and successfully provides a glimpse of what the future in molecular cardiology research holds. Understanding the molecular basis of cardiovascular diseases is no longer reserved for the basic scientist. Clinicians and healthcare professionals will need a working knowledge of the cellular and molecular pathogenetic mechanisms of cardiac diseases, because their treatment will require application of these advances.
From The Critics
Reviewer: Keith G Hickey, MD, BS (Ochsner Clinic Foundation)
Description: This book explores the latest developments in molecular cardiology research covering the molecular basis of cardiovascular diseases.
Purpose: The purpose is to discuss the molecular biology of cardiovascular diseases. This book provides overviews of the major themes in molecular cardiology, including cardiac function, coronary artery disease, arrhythmias, vascular diseases and risk factors. The authors make these complex topics easy to understand.
Audience: This book is intended for clinicians, scientists, students, and healthcare professionals who want to keep abreast of current findings in molecular cardiology research. The authors are all leading specialists in their fields.
Features: The book is divided into six sections, which are subdivided into chapters, beginning with a historical overview of the major themes in molecular cardiology: genetics, the molecular biology of the cardiovascular system, genomics and gene therapy and stem cells in cardiovascular disease. The next part covers cardiac function and dysfunction, including inherited diseases such as hypertrophic cardiomyopathies and muscular dystrophies that affect the heart. Part three addresses coronary artery disease. Section four on cardiac arrhythmias is timely given the recent progress in understanding the molecular basis and genetics of ventricular arrhythmias and sudden death. This is followed by a section on vascular diseases, which contains state-of-the art chapters on the molecular events that regulate angiogenesis. The book concludes with an excellent section on risk factors, summarizing the molecular basis of lipid metabolism, the biology of aging and the consequences of diabetes. Throughout each section several chapters are dedicated to treatment strategies which clinicians will find relevant. These chapters have excellent tables, photomicrographs, and figures that help illustrate concepts and aid understanding of the text.
Assessment: The authors have written a unique book that examines the latest developments in molecular cardiology and successfully provides a glimpse of what the future in molecular cardiology research holds. Understanding the molecular basis of cardiovascular diseases is no longer reserved for the basic scientist. Clinicians and healthcare professionals will need a working knowledge of the cellular and molecular pathogenetic mechanisms of cardiac diseases, because their treatment will require application of these advances.
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Product Details

  • ISBN-13: 9781588292018
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/1/2005
  • Series: Contemporary Cardiology Series
  • Edition description: 2005
  • Edition number: 1
  • Pages: 618
  • Product dimensions: 8.84 (w) x 11.44 (h) x 1.39 (d)

Table of Contents

Part I. Overview

Cardiovascular Genetics

Christopher Semsarian and Christine Seidman

Molecular Biology Applications in Cardiovascular Medicine

Eugene Yang, Scott M. Wasserman, Tatsuro Ishida, Raymond Tabibiazar, and Thomas Quertermous

Genomics and Its Application to Cardiovascular Disease

Robert Roberts

Gene Therapy and Cardiovascular Diseases

Yi Chu, Neal L. Weintraub, and Donald D. Heistad

Stem Cells and Progenitor Cells in Cardiovascular Disease

Jalees Rehman and Keith L. March

Part II. Myocardial Disease

Development of the Vertebrate Heart

Mabelle Ashe and David Bader

Inherited Myocardial Diseases

Elizabeth M. McNally

Receptor-Signaling Pathways in Heart Failure

Shayela Suvarna, Liza Barki-Harrington, Miwako Suzuki, Philippe Le Corvoisier, and Howard A. Rockman

Recent Insights into the Molecular Pathophysiology of Viral Myocarditis

Tony Tran, Roger D. Rossen, and Douglas L. Mann

Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease

Vidu Garg and Deepak Srivastava

Part III. Coronary Artery Disease

Coronary Artery Development

Mark W. Majesky

Atherosclerosis

George A. Stouffer

Antiplatelet Drugs

Karlheinz Peter

Myocardial Infarction

D. Douglas Miller and Steven C. Herrmann

Transplant Arteriopathy: Pathology, Pathogenesis, and Prospects for Treatment

Joannis Vamvakopoulos, Einari Aavik, Daniel du Toit, Pekka Häyry, and Minnie Sarwal

Thrombolysis: Scientific Basis for Current Therapy

Guy L. Reed III

Coronary Restenosis

Julius Aitsebaomo, Martin Moser, Susan Smyth, and Cam Patterson

Part IV. Arrhythmias

Induction and Patterning of Purkinje Fiber Network

Takashi Mikawa, Robert G. Gourdie, Kimiko Takebayashi-Suzuki, Nobuyuki Kanzawa, David J. Pennisi, Clifton P. Poma, and Maxim Shulimovich

Mechanisms of Sudden Cardiac Death

Wayne E. Cascio

Gene Therapy for Cardiac Arrhythmias

J. Kevin Donahue and Eduardo Marbán

Genetics and Arrhythmias

Kui Hong and Ramon Brugada

Part V. Vascular Diseases

Therapeutic Angiogenesis for Ischemic Vascular Disease

Jai Pal Singh and J. Anthony Ware

Nitric Oxide in Cardiovascular Biology and Pathophysiology

Marshall A. Corson

Vasculitis

Ronald J. Falk and J. Charles Jennette

Primary Pulmonary Hypertension

Evangelos D. Michelakis and Stephen L. Archer

The Molecular Basis of Cerebrovascular Malformations

Douglas A. Marchuk

Thrombotic Vascular Disease

Stephan Moll and Gilbert C. White II

Part VI. Risk Factors

Risk Factors

Ngoc-Anh Le and W. Virgil Brown

Vascular Aging: From Molecular to Clinical Cardiology

Samer S. Najjar and Edward G. Lakatta

Oxidative Stress

Nageswara R. Madamanchi and Marschall S. Runge

Diabetes Mellitus: An Important Cardiovascular Risk Factor

David R. Clemmons

Vascular Inflammation as a Cardiovascular Risk Factor

Allan R. Brasier, Adrian Recinos III, and Mohsen S. Eledrisi

Index

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