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Doody's Review ServiceReviewer: Keith G Hickey, MD, BS (Ochsner Clinic Foundation)
Description: This book explores the latest developments in molecular cardiology research covering the molecular basis of cardiovascular diseases.
Purpose: The purpose is to discuss the molecular biology of cardiovascular diseases. This book provides overviews of the major themes in molecular cardiology, including cardiac function, coronary artery disease, arrhythmias, vascular diseases and risk factors. The authors make these complex topics easy to understand.
Audience: This book is intended for clinicians, scientists, students, and healthcare professionals who want to keep abreast of current findings in molecular cardiology research. The authors are all leading specialists in their fields.
Features: The book is divided into six sections, which are subdivided into chapters, beginning with a historical overview of the major themes in molecular cardiology: genetics, the molecular biology of the cardiovascular system, genomics and gene therapy and stem cells in cardiovascular disease. The next part covers cardiac function and dysfunction, including inherited diseases such as hypertrophic cardiomyopathies and muscular dystrophies that affect the heart. Part three addresses coronary artery disease. Section four on cardiac arrhythmias is timely given the recent progress in understanding the molecular basis and genetics of ventricular arrhythmias and sudden death. This is followed by a section on vascular diseases, which contains state-of-the art chapters on the molecular events that regulate angiogenesis. The book concludes with an excellent section on risk factors, summarizing the molecular basis of lipid metabolism, the biology of aging and the consequences of diabetes. Throughout each section several chapters are dedicated to treatment strategies which clinicians will find relevant. These chapters have excellent tables, photomicrographs, and figures that help illustrate concepts and aid understanding of the text.
Assessment: The authors have written a unique book that examines the latest developments in molecular cardiology and successfully provides a glimpse of what the future in molecular cardiology research holds. Understanding the molecular basis of cardiovascular diseases is no longer reserved for the basic scientist. Clinicians and healthcare professionals will need a working knowledge of the cellular and molecular pathogenetic mechanisms of cardiac diseases, because their treatment will require application of these advances.