Principles of Molecular Rheumatology / Edition 1

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Overview

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the bio chemical mechanisms by which apoptosis, cell signaling, complement, li pids, and viruses contribute to disease expression, and detail both im mune and nonimmune cell function in rheumatic diseases. Their review o f the major rheumatic diseases integrates the cellular, biochemical, a nd molecular biological mechanisms that are important in rheumatic dis ease pathogenesis. Path-breaking and illuminating, Principles of Molec ular Rheumatology expands the envelope of clinical understanding to re veal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging fo r its optimal treatment.

The book contains black-and-white illustrations.

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Editorial Reviews

Deborah Jane Lenschow
The editor and contributors of this work provide a new approach to the study of rheumatology by integrating the most recent advances in biochemistry and cellular and molecular biology with the pathogenesis of the major rheumatic diseases and the therapeutics being used today. The editor and a panel of respected clinicians and scientists provide a resource to understand the basic cellular and molecular biology that plays a role in rheumatic disease. Clinical trainees in the field of rheumatology are the intended audience. In the first two sections of the book basic cellular and molecular issues such as T and B cell activation, apoptosis, viral infections, and the complement system are covered. In the third section contributors then take a unique approach to the major rheumatic disorders by integrating the basic biological mechanisms at play in these diseases. While many of the major categories of rheumatic diseases are covered, one of the few shortcomings of this textbook is that there is no discussion of two important areas -- crystal induced diseases and the seronegative spondyloarthropathies. Finally, current therapeutics that are utilized for the treatment of these diseases are discussed in terms of their molecular and cellular mechanism of actions. Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approiach allows clinical rheumatologists to gain a better understanding of the cellular andmolecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.
Booknews
Specialist clinicians and researchers, most from the US and Canada, have assembled an introduction and reference on how recent findings in cellular and molecular biology have been applied to rheumatology. They begin by setting out the molecular and cellular mechanisms that are central to many rheumatic diseases, then examine the pathogenesis of rheumatic diseases and molecular aspects of treating them. The individual contributions consider fairly broad topics, among them viruses, transcription factors, monocytes and macrophages, animal models, systemic sclerosis, heritable disorders of connective tissue, corticosteroids, and gene therapy. The perspective is intended to complement rather than replace classical textbooks for fellows and practitioners. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Deborah Jane Lenschow, MD, PhD (Washington University School of Medicine)
Description: The editor and contributors of this work provide a new approach to the study of rheumatology by integrating the most recent advances in biochemistry and cellular and molecular biology with the pathogenesis of the major rheumatic diseases and the therapeutics being used today.
Purpose: The editor and a panel of respected clinicians and scientists provide a resource to understand the basic cellular and molecular biology that plays a role in rheumatic disease.
Audience: Clinical trainees in the field of rheumatology are the intended audience.
Features: In the first two sections of the book basic cellular and molecular issues such as T and B cell activation, apoptosis, viral infections, and the complement system are covered. In the third section contributors then take a unique approach to the major rheumatic disorders by integrating the basic biological mechanisms at play in these diseases. While many of the major categories of rheumatic diseases are covered, one of the few shortcomings of this textbook is that there is no discussion of two important areas — crystal induced diseases and the seronegative spondyloarthropathies. Finally, current therapeutics that are utilized for the treatment of these diseases are discussed in terms of their molecular and cellular mechanism of actions.
Assessment: Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approiach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781617371820
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/19/2010
  • Series: Current Molecular Medicine Series , #1
  • Edition description: Softcover reprint of hardcover 1st ed. 2000
  • Edition number: 1
  • Pages: 542
  • Product dimensions: 1.14 (w) x 7.00 (h) x 10.00 (d)

Table of Contents

Part I. Molecular Mechanisms in Rheumatic Diseases

Genetics
Peter K. Gregersen

Viruses
Andras Perl

Apoptosis
John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou

Humoral Response
Gary S. Gilkeson

T-Cell Signaling
Gary A. Koretzky and Erik J. Peterson

Adhesion and Costimulatory Molecules
Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler

Transcription Factors
Henry K. Wong

Immune Complexes
Mark H. Wener

Complement
V. Michael Holers

Eicosanoids and Other Bioactive Lipids
Leslie J. Crofford

Collagens
Sergio A. Jiménez

Part II. Cellular Mechanisms in Rheumatic Diseases

T-Lymphocytes
Nilamadhab Mishra and Gary M. Kammer

B-Lymphocytes
Robert F. Ashman

Monocytes and Macrophages
James M. K. Chan and Sharon M. Wahl

Polymorphonuclear Cells
Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein

Synoviocytes
David E. Yocum

Chondrocytes
Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud

Osteoblasts and Osteoclasts
Stavros C. Manolagas

Animal Models
Thomas J. Lang and Charles S. Via

Part III. Pathogenesis of Rheumatic Diseases

Systemic Lupus Erythematosus
Stamatis-Nick C. Liossis and George C. Tsokos

Rheumatoid Arthritis
Richard M. Pope and Harris Perlman

Inflammatory Myopathies
Norbert Goebels and Reinhard Hohlfeld

Systemic Sclerosis
Timothy M. Wright

Vasculitis
Jörg J. Goronzy and Cornelia M. Weyand

Osteoarthritis
Robin Poole and Ginette Webb

Osteoporosis
Stavros C. Manolagas

Heritable Disorders of Connective Tissue
Petros Tsipouras

Part IV. Molecular Aspects of Treatment of RheumaticDiseases

Corticosteroids
Henry K. Wong and George C. Tsokos

Cytotoxic Drugs
David A. Fox and W. Joseph McCune

Complement Inhibitors
Savvas C. Makrides

Cytokine Response Modifiers
Richard E. Jones and Larry W. Moreland

Restoration of Immune Tolerance
Woodruff Emlen

Metalloproteases and Their Modulation as Treatment in Osteoarthritis
Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier

Gene Therapy
Robert P. Kimberly

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