Principles of Molecular Rheumatology / Edition 1

Principles of Molecular Rheumatology / Edition 1

by George C. Tsokos
     
 

Rheumatic diseases are complex in nature and require for their optimal diagnosis and treatment a critical understanding of the mechanisms that lead to their tissue pathology and various clinical manifestations. In Principles of Molecular Rheumatology, George Tsokos and a panel of authoritative clinicians and researchers synthesize all the latest findings from

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Overview

Rheumatic diseases are complex in nature and require for their optimal diagnosis and treatment a critical understanding of the mechanisms that lead to their tissue pathology and various clinical manifestations. In Principles of Molecular Rheumatology, George Tsokos and a panel of authoritative clinicians and researchers synthesize all the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. The authors also discuss the molecular and cellular mechanisms of action following the administration of the principal drugs used in rheumatology.

Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

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Product Details

ISBN-13:
9781617371820
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/19/2010
Series:
Current Molecular Medicine Series, #1
Edition description:
Softcover reprint of hardcover 1st ed. 2000
Pages:
542
Product dimensions:
1.14(w) x 7.00(h) x 10.00(d)

Related Subjects

Table of Contents

Part I. Molecular Mechanisms in Rheumatic Diseases

Genetics
Peter K. Gregersen

Viruses
Andras Perl

Apoptosis
John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou

Humoral Response
Gary S. Gilkeson

T-Cell Signaling
Gary A. Koretzky and Erik J. Peterson

Adhesion and Costimulatory Molecules
Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler

Transcription Factors
Henry K. Wong

Immune Complexes
Mark H. Wener

Complement
V. Michael Holers

Eicosanoids and Other Bioactive Lipids
Leslie J. Crofford

Collagens
Sergio A. Jiménez

Part II. Cellular Mechanisms in Rheumatic Diseases

T-Lymphocytes
Nilamadhab Mishra and Gary M. Kammer

B-Lymphocytes
Robert F. Ashman

Monocytes and Macrophages
James M. K. Chan and Sharon M. Wahl

Polymorphonuclear Cells
Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein

Synoviocytes
David E. Yocum

Chondrocytes
Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud

Osteoblasts and Osteoclasts
Stavros C. Manolagas

Animal Models
Thomas J. Lang and Charles S. Via

Part III. Pathogenesis of Rheumatic Diseases

Systemic Lupus Erythematosus
Stamatis-Nick C. Liossis and George C. Tsokos

Rheumatoid Arthritis
Richard M. Pope and Harris Perlman

Inflammatory Myopathies
Norbert Goebels and Reinhard Hohlfeld

Systemic Sclerosis
Timothy M. Wright

Vasculitis
Jörg J. Goronzy and Cornelia M. Weyand

Osteoarthritis
Robin Poole and Ginette Webb

Osteoporosis
Stavros C. Manolagas

Heritable Disorders of Connective Tissue
Petros Tsipouras

Part IV. Molecular Aspects of Treatment of RheumaticDiseases

Corticosteroids
Henry K. Wong and George C. Tsokos

Cytotoxic Drugs
David A. Fox and W. Joseph McCune

Complement Inhibitors
Savvas C. Makrides

Cytokine Response Modifiers
Richard E. Jones and Larry W. Moreland

Restoration of Immune Tolerance
Woodruff Emlen

Metalloproteases and Their Modulation as Treatment in Osteoarthritis
Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier

Gene Therapy
Robert P. Kimberly

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