Principles of Molecular Rheumatology / Edition 1

by George C. Tsokos

Overview

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

Product Details

ISBN-13:	9781617371820
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/19/2010
Series:	Current Molecular Medicine , #1
Edition description:	Softcover reprint of hardcover 1st ed. 2000
Pages:	542
Product dimensions:	7.01(w) x 10.00(h) x 0.39(d)

About the Author

Tsokos, George C., MD (Uniformed Services Univ of the Health Sciences)

Table of Contents

Part I. Molecular Mechanisms in Rheumatic Diseases Genetics Peter K. Gregersen Viruses Andras Perl Apoptosis John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou Humoral Response Gary S. Gilkeson T-Cell Signaling Gary A. Koretzky and Erik J. Peterson Adhesion and Costimulatory Molecules Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler Transcription Factors Henry K. Wong Immune Complexes Mark H. Wener Complement V. Michael Holers Eicosanoids and Other Bioactive Lipids Leslie J. Crofford Collagens Sergio A. Jiménez Part II. Cellular Mechanisms in Rheumatic Diseases T-Lymphocytes Nilamadhab Mishra and Gary M. Kammer B-Lymphocytes Robert F. Ashman Monocytes and Macrophages James M. K. Chan and Sharon M. Wahl Polymorphonuclear Cells Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein Synoviocytes David E. Yocum Chondrocytes Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud Osteoblasts and Osteoclasts Stavros C. Manolagas Animal Models Thomas J. Lang and Charles S. Via Part III. Pathogenesis of Rheumatic Diseases Systemic Lupus Erythematosus Stamatis-Nick C. Liossis and George C. Tsokos Rheumatoid Arthritis Richard M. Pope and Harris Perlman Inflammatory Myopathies Norbert Goebels and Reinhard Hohlfeld Systemic Sclerosis Timothy M. Wright Vasculitis Jörg J. Goronzy and Cornelia M. Weyand Osteoarthritis Robin Poole and Ginette Webb Osteoporosis Stavros C. Manolagas Heritable Disorders of Connective Tissue Petros Tsipouras Part IV. Molecular Aspects of Treatment of RheumaticDiseases Corticosteroids Henry K. Wong and George C. Tsokos Cytotoxic Drugs David A. Fox and W. Joseph McCune Complement Inhibitors Savvas C. Makrides Cytokine Response Modifiers Richard E. Jones and Larry W. Moreland Restoration of Immune Tolerance Woodruff Emlen Metalloproteases and Their Modulation as Treatment in Osteoarthritis Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier Gene Therapy Robert P. Kimberly

Editorial Reviews

3 Stars from Doody

The editor and contributors of this work provide a new approach to the study of rheumatology by integrating the most recent advances in biochemistry and cellular and molecular biology with the pathogenesis of the major rheumatic diseases and the therapeutics being used today. The editor and a panel of respected clinicians and scientists provide a resource to understand the basic cellular and molecular biology that plays a role in rheumatic disease. Clinical trainees in the field of rheumatology are the intended audience. In the first two sections of the book basic cellular and molecular issues such as T and B cell activation, apoptosis, viral infections, and the complement system are covered. In the third section contributors then take a unique approach to the major rheumatic disorders by integrating the basic biological mechanisms at play in these diseases. While many of the major categories of rheumatic diseases are covered, one of the few shortcomings of this textbook is that there is no discussion of two important areas -- crystal induced diseases and the seronegative spondyloarthropathies. Finally, current therapeutics that are utilized for the treatment of these diseases are discussed in terms of their molecular and cellular mechanism of actions. Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approiach allows clinical rheumatologists to gain a better understanding of the cellular andmolecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.

Deborah Jane Lenschow

Specialist clinicians and researchers, most from the US and Canada, have assembled an introduction and reference on how recent findings in cellular and molecular biology have been applied to rheumatology. They begin by setting out the molecular and cellular mechanisms that are central to many rheumatic diseases, then examine the pathogenesis of rheumatic diseases and molecular aspects of treating them. The individual contributions consider fairly broad topics, among them viruses, transcription factors, monocytes and macrophages, animal models, systemic sclerosis, heritable disorders of connective tissue, corticosteroids, and gene therapy. The perspective is intended to complement rather than replace classical textbooks for fellows and practitioners. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Deborah Jane Lenschow, MD, PhD (Washington University School of Medicine)
Description: The editor and contributors of this work provide a new approach to the study of rheumatology by integrating the most recent advances in biochemistry and cellular and molecular biology with the pathogenesis of the major rheumatic diseases and the therapeutics being used today.
Purpose: The editor and a panel of respected clinicians and scientists provide a resource to understand the basic cellular and molecular biology that plays a role in rheumatic disease.
Audience: Clinical trainees in the field of rheumatology are the intended audience.
Features: In the first two sections of the book basic cellular and molecular issues such as T and B cell activation, apoptosis, viral infections, and the complement system are covered. In the third section contributors then take a unique approach to the major rheumatic disorders by integrating the basic biological mechanisms at play in these diseases. While many of the major categories of rheumatic diseases are covered, one of the few shortcomings of this textbook is that there is no discussion of two important areas — crystal induced diseases and the seronegative spondyloarthropathies. Finally, current therapeutics that are utilized for the treatment of these diseases are discussed in terms of their molecular and cellular mechanism of actions.
Assessment: Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approiach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.

Doody's Review Service

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal

"It contains many figures of good quality." - Journal of Endocrine Genetics

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing

From the Publisher