Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy / Edition 2

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This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system.

Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development.

The fully searchable online text and an image bank are available on thePoint.

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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This book is a collaborative project from the Harvard Medical School Faculty and Students that departs from traditional pharmacology textbooks in that it is designed around molecular targets rather than drug classes. It provides an understanding of drug action in the context of human physiology, biochemistry, and pathophysiology.
Purpose: The purpose is to provide a unique textbook to meet the needs of medical students based on a collaborative effort between students and faculty experts. This effort has led to an extraordinarily superb book with outstanding illustrations that discusses pharmacology from a conceptual viewpoint rather than categorizing drugs in the framework of drug classes. This will become a valuable textbook for many courses in medical and basic pharmacology.
Audience: This is a conceptual pharmacology textbook for medical, dental, and pharmacy students, but practicing physicians and graduate students in experimental pharmacology will also find it to be an excellent textbook.
Features: The first section deals with the general principles of pharmacology. Subsequent sections address the principles of neuropharmacology, cardiovascular pharmacology, endocrine pharmacology, chemotherapy, inflammation, and immune pharmacology and toxicology. Section VIII deals with contemporary approaches to drug discovery, development, and delivery while the last section discusses the fundamentals of drug evaluation and pharmacogenomics. Highlights include the introduction of each chapter with a clinical case specific to a target system followed by relevant biochemistry, physiology, and pathophysiology of the system; over 400 two-color figures that illustrate drug targets in the treatment of diseases; summary tables of drugs by mechanism, class, adverse effects, interactions, and contraindications in a format that allows rapid review; and the application of up-to-date molecular and cellular science allowing the incorporation of new drugs into the learner's knowledge base.
Assessment: This book will be a very strong competitor to Katzung's Basic and Clinical Pharmacology, 9th edition (McGraw-Hill, 2004). I intend to adopt it for our graduate course in pharmacology and then decide whether to also adopt it for the medical pharmacology course. The book is both unique and excellent with the highest quality of well-designed illustrations. I strongly recommend it.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780781783552
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 5/28/2007
  • Edition description: Second Edition
  • Edition number: 2
  • Pages: 985
  • Product dimensions: 8.60 (w) x 10.70 (h) x 1.20 (d)

Table of Contents

Drug-Receptor Interactions
Drug Metabolism
Drug Toxicity


Fundamental Principles of Neuropharmacology
Principles of Cellular Excitability and Electrochemical Transmission
Principles of Nervous System Physiology and Pharmacology

Principles of Autonomic and Peripheral Nervous System Pharmacology
Cholinergic Pharmacology
Adrenergic Pharmacology
Local Anesthetic Pharmacology

Principles of Central Nervous System Pharmacology
Pharmacology of GABAergic and Glutamatergic Neurotransmission
Pharmacology of Dopaminergic Neurotransmission
Pharmacology of Central Adrenergic and Serotonergic Neurotransmission
Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System
General Anesthetic Pharmacology
Pharmacology of Analgesia
Pharmacology of Drug and Alcohol Abuse and Dependence

Pharmacology of Cardiac Rhythm
Pharmacology of Cardiac Contractility
Pharmacology of Volume Regulation
Pharmacology of Vascular Tone
Pharmacology of Hemostasis and Thrombosis
Pharmacology of Cholesterol and Lipoprotein Metabolism
Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure

Pharmacology of the Hypothalamus and Pituitary Gland
Pharmacology of the Thyroid Gland
Pharmacology of the Adrenal Cortex
Pharmacology of Reproduction
Pharmacology of the Endocrine Pancreas
Pharmacology of Bone Mineral Homeostasis

Principles of Antimicrobial and Antineoplastic Pharmacology
Pharmacology of Bacterial Infections: Central Dogma Processes
Pharmacology of Bacterial Infections: Cell Wall Synthesis
Pharmacology of Fungal Infections
Pharmacology of Parasitic Infections
Pharmacology of Viral Infections
Pharmacology of Cancer: DNA Synthesis, Stability, and Maintenance
Pharmacology of Cancer: Signal Transduction
Principles of Combination Chemotherapy

Principles of Inflammation and the Immune System
Pharmacology of Eicosanoids
Histamine Pharmacology
Pharmacology of Hematopoietic and Immune Cell Stimulation
Pharmacology of Immunosuppression
Integrative Inflammation Pharmacology: Peptic Ulcer Disease
Integrative Inflammation Pharmacology: Asthma
Integrative Inflammation Pharmacology: Gout

Drug Discovery and Preclinical Development
Clinical Drug Evaluation and Regulatory Approval
Detection and Management of Adverse Events in Marketed Drugs


Protein-Based and Gene Therapies
Drug Delivery Modalities

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  • Anonymous

    Posted September 2, 2008

    Go with the Katzung Book

    If you're like me, you probably got this book because your med school prof 'recommended' it as a guide to their course. Let me be the first to tell you that instead of going with the book which was 'written by students for students,' you should go with the book which was 'written by a good teacher.' Many parts of this book have unclear wording that more reflect the understanding of the writer as opposed to wording which helps students understand. Since at our school we had access to the Katzung book via Stat!Ref, I frequently clicked over to it online in order to clear up things which were not clear in this book. For example, in the anesthesia section, when there is an unclear concept regarding low/high solubility drugs, the authors try to use math and pharmacokinetics to coax the reader into understanding the solution, whereas the Katzung book presents a simple picture and analogy. There's a reason the Katzung book is consistently among B&N's top 1000 in sales rank, and this one is much lower. Try out the Katzung book, and you will not regret it.

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