Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy [NOOK Book]

Overview

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, serves as the primary textbook for a first course in pharmacology. It offers an integrated mechanism, and systems-based approach that incorporates the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition reflects current research findings and features more than 400 full-color illustrations and Drug Summary Tables.
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Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy

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Overview

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, serves as the primary textbook for a first course in pharmacology. It offers an integrated mechanism, and systems-based approach that incorporates the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition reflects current research findings and features more than 400 full-color illustrations and Drug Summary Tables.
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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This is a basic pharmacology textbook with an emphasis on the biochemical and cellular mechanisms required for understanding the treatment of pathophysiological conditions.
Purpose: This is a collaborative effort by Harvard medical faculty and students to prepare a book useful for students who are studying pharmacology as part of their curriculum. This is particularly useful for courses that focus on the biochemical, cellular, and physiological basis of drug action.
Audience: The book is designed for medical, dental, and pharmacy students, but I find it most useful as a basic pharmacology text for PhD graduate students who have a strong background in molecular and cellular principles but a weaker background in anatomic and physiologic principles as seen in most integrative graduate programs today. This book markedly helps fill the void of anatomical- and physiological-based courses in modern graduate programs.
Features: The strength of this book lies in the numerous excellent figures that explain the cellular and molecular aspects of drug actions on a physiological basis. This second edition has 100 new or extensively redesigned figures. Unfortunately, the color scheme of the figures does not show up as well on PowerPoint slides as do figures from many competing texts. The sections on fundamentals of drug development and regulation and frontiers in pharmacology provide a perspective not found in most fundamental pharmacology books. An access code is provided for an electronic version of the book and images. A companion case-based workbook, Principles of Pharmacology Workbook, by Farrell (Lippincott Williams & Wilkins, 2008), reviews important concepts and drug classes in a question-and-answer format that is valuable for course and board exam review.
Assessment: This edition is updated and improved in content and clarity from the first edition. There are many excellent pharmacology textbooks to choose from and I prefer this one for our graduate student course in pharmacology. I still prefer Katzung's Basic & Clinical Pharmacology, 10th edition (McGraw-Hill, 2006), for teaching our medical students because of its superior discussion on the clinical use of drugs.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781469821832
  • Publisher: Wolters Kluwer Health
  • Publication date: 10/31/2012
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 3
  • Pages: 976
  • Sales rank: 965,962
  • File size: 51 MB
  • Note: This product may take a few minutes to download.

Table of Contents

Foreword
Preface
Acknowledgments
Contributors
Sect. I Fundamental principles of pharmacology 1
1 Drug-receptor interactions 3
2 Pharmacodynamics 17
3 Pharmacokinetics 27
4 Drug metabolism 45
Sect. II Principles of neuropharmacology 55
5 Principles of cellular excitability and electrochemical transmission 59
6 Principles of nervous system physiology and pharmacology 71
7 Cholinergic pharmacology 89
8 Adrenergic pharmacology 107
9 Local anesthetic pharmacology 121
10 Pharmacology of excitatory and inhibitory neurotransmission 139
11 Pharmacology of dopaminergic neurotransmission 161
12 Pharmacology of affective disorders 179
13 Pharmacology of abnormal electrical neurotransmission in the central nervous system 193
14 General anesthetic pharmacology 205
15 Pharmacology of analgesia 229
16 Pharmacology of chemical dependence and addiction 247
Sect. III Principles of cardiovascular pharmacology 265
17 Pharmacology of cardiac rhythm 267
18 Pharmacology of cardiac contractility 285
19 Pharmacology of volume regulation 299
20 Pharmacology of vascular tone 317
21 Pharmacology of hemostasis and thrombosis 335
22 Pharmacology of cholesterol and lipoprotein metabolism 357
23 Integrative cardiovascular pharmacology : hypertension, ischemic heart disease, and congestive heart failure 375
Sect. IV Principles of endocrine pharmacology 401
24 Pharmacology of the hypothalamus and pituitary gland 403
25 Pharmacology of the thyroid gland 415
26 Pharmacology of the adrenal cortex 425
27 Pharmacology of reproduction 441
28 Pharmacology to the endocrine pancreas 457
29 Pharmacology of bone mineral homeostasis 473
Sect. V Principles of chemotherapy 491
30 Principles of antimicrobial and antineoplastic pharmacology 493
31 Pharmacology of nucleotide synthesis 505
32 Pharmacology of DNA replication and mitosis 519
33 Pharmacology of transcription and translation 535
34 Pharmacology of viral replication 545
35 Pharmacology of the bacterial cell wall 565
36 Pharmacology of fungal infections 579
37 Pharmacology of parasitic infections 587
38 Principles of combination chemotherapy 603
Sect. VI Principles of inflammation and immune pharmacology 615
39 Principles of inflammation and the immune system 617
40 Pharmacology of eicosanoids 627
41 Histamine pharmacology 647
42 Pharmacology of hematopoietic and immune cell stimulation 655
43 Pharmacology of immunosuppression 667
44 Integrative inflammation pharmacology : peptic ulcer disease 683
45 Integrative inflammation pharmacology : asthma 695
46 Integrative inflammation pharmacology : gout 709
Sect. VII Principles of toxicology 717
47 Principles of toxicology 719
Sect. VIII Contemporary approaches to drug discovery, development and delivery 745
48 Drug discovery and development 747
49 Protein-based and gene therapies 757
50 Drug delivery mechanisms 781
Sect. IX Fundamentals of drug evaluation and pharmacogenomics 789
51 New drug evaluation and drug regulation 791
52 Pharmacogenomics 803
Crebit list 811
Index 815
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