Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy / Edition 3

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Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, is a primary textbook for a first course in pharmacology. It offers an integrated mechanism-based and systems-based approach, incorporating the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition features content reflecting current research findings, more than 400 full-color illustrations, Drug Summary Tables, and increased coverage of drug metabolism and the treatment of mycobacterial infections.

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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This book discusses pharmacology in the framework of human physiology, biochemistry, and pathophysiology. It uses the organization found in most traditional pharmacology textbooks and all chapters follow a strict presentation format. Drugs and information have been updated and the book is current through 2010.
Purpose: The authors state that this book represents a new approach to the teaching of a first- or second-year medical school pharmacology course. I agree with the objective, but there are better books with an emphasis on the clinical aspects of drug actions for teaching medical students. However, this book is superb for teaching a pharmacology graduate course.
Audience: It is designed for teaching pharmacology in the medical school curriculum, but is even better suited for teaching graduate students the principles of pharmacology. The authorship of this book is unique in that it is a collaboration of medical students, residents, and faculty with expertise in the content of each chapter.
Features: This book has a number of features that make it unique among pharmacology books. First, and most important, it has a strong focus on molecular and cellular mechanisms that contribute to the pathophysiology of diseases and the molecular actions of drugs used to treat these diseases. It emphasizes critical thinking, molecular understanding, and systems-based integration. Explanations are enriched by well-designed multicolored illustrations. (My one complaint about the illustrations is that the color does not project well on PowerPoint presentations unless the classroom has very dim lighting.) Each chapter is introduced with a well-written clinical vignette that ends with several "yellow light-bulb" questions regarding the case. These "yellow light-bulbs" are then inserted into the text where the explanation to the question is provided. Finally, each chapter ends with a well-designed signature drug summary table that lists drugs with mechanism of action, clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations. These tables allow students to quickly review all the drugs they need to know for examinations. However, detailed discussion of clinical application of drugs is more limited. Students and faculty have access via a PIN number to a website with the fully searchable eBook, PowerPoint presentations of figures for faculty, and, of course, a question bank test generator for students.
Assessment: This is an excellent textbook for teaching pharmacology to medical students and graduate students. I use this book for our Essentials of Pharmacology graduate course, but I still use Basic and Clinical Pharmacology, 11th edition, Katzung et al. (McGraw-Hill, 2009) for teaching medical students.
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Product Details

  • ISBN-13: 9781608312702
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 6/22/2011
  • Edition description: Third, North American Edition
  • Edition number: 3
  • Pages: 976
  • Sales rank: 182,326
  • Product dimensions: 8.40 (w) x 10.80 (h) x 1.20 (d)

Table of Contents

Section 1. Fundamental Principles of Pharmacology

Chapter 1. Drug-Receptor Interactions
Chapter 2. Pharmacodynamics
Chapter 3. Pharmacokinetics
Chapter 4. Drug Metabolism
Chapter 5. Drug Toxicity
Chapter 6  Pharmacogenomics
Section 2. Principles of Neuropharmacology
Section 2a. Fundamental Principles of Neuropharmacology
Chapter 7. Principles of Cellular Excitability and Electrochemical Transmission
Chapter 8. Principles of Nervous System Physiology and Pharmacology
Section 2b. Principles of Autonomic and Peripheral Nervous System Pharmacology
Chapter 9. Cholinergic Pharmacology
Chapter 10. Adrenergic Pharmacology
Chapter 11. Local Anesthetic Pharmacology
Section 2c. Principles of Central Nervous System Pharmacology
Chapter 12. Pharmacology of GABAergic and Glutamatergic Neurotransmission
Chapter 13. Pharmacology of Dopaminergic Neurotransmission
Chapter 14. Pharmacology of Serotonergic and Central Adrenergic Neurotransmission
Chapter 15. Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System
Chapter 16. General Anesthetic Pharmacology
Chapter 17. Pharmacology of Analgesia
Chapter 18. Pharmacology of Chemical Dependence and Addiction
Section 3. Principles of Cardiovascular Pharmacology
Chapter 19. Pharmacology of Cholesterol and Lipoprotein Metabolism
Chapter 20. Pharmacology of Volume Regulation
Chapter 21. Pharmacology of Vascular Tone
Chapter 22. Pharmacology of Hemostasis and Thrombosis
Chapter 23. Pharmacology of Cardiac Rhythm
Chapter 24. Pharmacology of Cardiac Contractility
Chapter 25. Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure
Section 4. Principles of Endocrine Pharmacology
Chapter 26. Pharmacology of the Hypothalamus and Pituitary Gland
Chapter 27. Pharmacology of the Thyroid Gland
Chapter 28. Pharmacology of the Adrenal Cortex
Chapter 29. Pharmacology of Reproduction
Chapter 30. Pharmacology of the Endocrine Pancreas
Chapter 31. Pharmacology of Bone Mineral Homeostasis
Section 5. Principles of Chemotherapy
Chapter 32. Principles of Antimicrobial and Antineoplastic Pharmacology
Chapter 33. Pharmacology of Bacterial Infections: DNA Replication, Transcription, and Translation
Chapter 34. Pharmacology of Bacterial and Mycobacterial Infections: Cell Wall Synthesis
Chapter 35. Pharmacology of Fungal Infections
Chapter 36. Pharmacology of Parasitic Infections
Chapter 37. Pharmacology of Viral Infections
Chapter 38. Pharmacology of Cancer: Genome Synthesis, Stability, and Maintenance
Chapter 39. Pharmacology of Cancer: Signal Transduction
Chapter 40. Principles of Combination Chemotherapy
Section 6. Principles of Inflammation and Immune Pharmacology
Chapter 41. Principles of Inflammation and the Immune System
Chapter 42. Pharmacology of Eicosanoids
Chapter 43. Histamine Pharmacology
Chapter 44. Pharmacology of Hematopoiesis and Immunomodulation
Chapter 45. Pharmacology of Immunosuppression
Chapter 46. Integrative Inflammation Pharmacology: Peptic Ulcer Disease
Chapter 47. Integrative Inflammation Pharmacology: Asthma
Chapter 48. Integrative Inflammation Pharmacology: Gout
Section 7. Fundamentals of Drug Development and Regulation
Chapter 49. Drug Discovery and Preclinical Development
Chapter 50. Clinical Drug Evaluation and Regulatory Approval
Chapter 51. Systematic Detection of Adverse Events in Marketed Drugs
Section 8. Poisoning by Drugs and Environmental Toxins
Chapter 52. Poisoning by Drugs and Environmental Toxins
Section 9. Frontiers in Pharmacology
Chapter 53. Protein-Based Therapies
Chapter 54. Drug Delivery Modalities

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