Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy / Edition 1

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Unlike other pharmacology texts organized by drug class, Principles of Pharmacology integrates relevant knowledge from the basic biomedical sciences -- physiology, pathophysiology, cell and molecular biology, biochemistry, anatomy, neurobiology, microbiology, and immunology -- to build an integrated, conceptual understanding of drug therapy. By discussing the therapeutic and adverse actions of drugs in the framework of the drug's mechanism of action, the book enables students to achieve a level of mastery in pharmacology that far surpasses that achieved by rote memorization. Content reflects recent advances in biological and biomedical science to improve understanding of mechanisms of drug action at the molecular level. Written and edited by Harvard Medical School students and faculty, the text blends the enthusiasm and perspective of student authors with the experience and expertise of faculty authors, to provide a comprehensive and consistent presentation of modern, mechanism-based pharmacology.
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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: This book is a collaborative project from the Harvard Medical School Faculty and Students that departs from traditional pharmacology textbooks in that it is designed around molecular targets rather than drug classes. It provides an understanding of drug action in the context of human physiology, biochemistry, and pathophysiology.
Purpose: The purpose is to provide a unique textbook to meet the needs of medical students based on a collaborative effort between students and faculty experts. This effort has led to an extraordinarily superb book with outstanding illustrations that discusses pharmacology from a conceptual viewpoint rather than categorizing drugs in the framework of drug classes. This will become a valuable textbook for many courses in medical and basic pharmacology.
Audience: This is a conceptual pharmacology textbook for medical, dental, and pharmacy students, but practicing physicians and graduate students in experimental pharmacology will also find it to be an excellent textbook.
Features: The first section deals with the general principles of pharmacology. Subsequent sections address the principles of neuropharmacology, cardiovascular pharmacology, endocrine pharmacology, chemotherapy, inflammation, and immune pharmacology and toxicology. Section VIII deals with contemporary approaches to drug discovery, development, and delivery while the last section discusses the fundamentals of drug evaluation and pharmacogenomics. Highlights include the introduction of each chapter with a clinical case specific to a target system followed by relevant biochemistry, physiology, and pathophysiology of the system; over 400 two-color figures that illustrate drug targets in the treatment of diseases; summary tables of drugs by mechanism, class, adverse effects, interactions, and contraindications in a format that allows rapid review; and the application of up-to-date molecular and cellular science allowing the incorporation of new drugs into the learner's knowledge base.
Assessment: This book will be a very strong competitor to Katzung's Basic and Clinical Pharmacology, 9th edition (McGraw-Hill, 2004). I intend to adopt it for our graduate course in pharmacology and then decide whether to also adopt it for the medical pharmacology course. The book is both unique and excellent with the highest quality of well-designed illustrations. I strongly recommend it.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780781746786
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 4/13/2004
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 880
  • Product dimensions: 8.40 (w) x 10.80 (h) x 1.30 (d)

Table of Contents

Sect. I Fundamental principles of pharmacology 1
1 Drug-receptor interactions 3
2 Pharmacodynamics 17
3 Pharmacokinetics 27
4 Drug metabolism 45
Sect. II Principles of neuropharmacology 55
5 Principles of cellular excitability and electrochemical transmission 59
6 Principles of nervous system physiology and pharmacology 71
7 Cholinergic pharmacology 89
8 Adrenergic pharmacology 107
9 Local anesthetic pharmacology 121
10 Pharmacology of excitatory and inhibitory neurotransmission 139
11 Pharmacology of dopaminergic neurotransmission 161
12 Pharmacology of affective disorders 179
13 Pharmacology of abnormal electrical neurotransmission in the central nervous system 193
14 General anesthetic pharmacology 205
15 Pharmacology of analgesia 229
16 Pharmacology of chemical dependence and addiction 247
Sect. III Principles of cardiovascular pharmacology 265
17 Pharmacology of cardiac rhythm 267
18 Pharmacology of cardiac contractility 285
19 Pharmacology of volume regulation 299
20 Pharmacology of vascular tone 317
21 Pharmacology of hemostasis and thrombosis 335
22 Pharmacology of cholesterol and lipoprotein metabolism 357
23 Integrative cardiovascular pharmacology : hypertension, ischemic heart disease, and congestive heart failure 375
Sect. IV Principles of endocrine pharmacology 401
24 Pharmacology of the hypothalamus and pituitary gland 403
25 Pharmacology of the thyroid gland 415
26 Pharmacology of the adrenal cortex 425
27 Pharmacology of reproduction 441
28 Pharmacology to the endocrine pancreas 457
29 Pharmacology of bone mineral homeostasis 473
Sect. V Principles of chemotherapy 491
30 Principles of antimicrobial and antineoplastic pharmacology 493
31 Pharmacology of nucleotide synthesis 505
32 Pharmacology of DNA replication and mitosis 519
33 Pharmacology of transcription and translation 535
34 Pharmacology of viral replication 545
35 Pharmacology of the bacterial cell wall 565
36 Pharmacology of fungal infections 579
37 Pharmacology of parasitic infections 587
38 Principles of combination chemotherapy 603
Sect. VI Principles of inflammation and immune pharmacology 615
39 Principles of inflammation and the immune system 617
40 Pharmacology of eicosanoids 627
41 Histamine pharmacology 647
42 Pharmacology of hematopoietic and immune cell stimulation 655
43 Pharmacology of immunosuppression 667
44 Integrative inflammation pharmacology : peptic ulcer disease 683
45 Integrative inflammation pharmacology : asthma 695
46 Integrative inflammation pharmacology : gout 709
Sect. VII Principles of toxicology 717
47 Principles of toxicology 719
Sect. VIII Contemporary approaches to drug discovery, development and delivery 745
48 Drug discovery and development 747
49 Protein-based and gene therapies 757
50 Drug delivery mechanisms 781
Sect. IX Fundamentals of drug evaluation and pharmacogenomics 789
51 New drug evaluation and drug regulation 791
52 Pharmacogenomics 803
Crebit list 811
Index 815
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