Principles of Precision Hormone Therapy: Healthy Aging and Prevention of Chronic Disease

by Franck Mauvais-Jarvis (Editor)

Overview

Hormones—such as estrogens, testosterone, thyroid hormones, and growth hormone—are essential for metabolic homeostasis in all cells. However, their levels decline with age, contributing to aging and chronic disease. Proper hormone therapy can help delay the onset of age-related diseases, yet there is currently no authoritative, up-to-date resource on precision hormone optimization for healthy aging. Current standard of care textbooks rely on outdated concepts, while books aimed at non-specialist clinicians and patients are often written by non-experts and lack a solid scientific foundation.

This book bridges that gap by presenting cutting-edge scientific data and insights from leading academic and private practice experts on the role of hormone optimization in healthy aging. It dispels common misconceptions about hormone therapy risks and highlights the proven benefits of precision hormone treatments. Drawing on both scientific evidence and clinical experience, it explores the distinctions between synthetic hormones and bioidentical, physiological hormones. Designed to challenge conventional thinking, this book aims to inspire discussion and further research among scientists and healthcare practitioners. It is an essential resource for basic and clinical researchers seeking translational knowledge on hormone therapy, as well as clinicians looking to integrate hormone optimization into their practice.

Product Details

ISBN-13:	9783031896491
Publisher:	Springer Nature Switzerland
Publication date:	08/10/2025
Pages:	487
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Dr. Franck Mauvais-Jarvis is a physician-scientist specializing in endocrinology, metabolism, and hormone therapy. Trained in top endocrinology programs at Paris university hospitals, he has practiced in the U.S. for over 20 years. He also holds a PhD in Biochemistry and Molecular Biology from Paris. Following postdoctoral training at the Joslin Diabetes Center and Harvard Medical School, he became a leading expert on the roles of estrogens, androgens, and biological sex in metabolism, diabetes, and obesity.

Dr. Mauvais-Jarvis currently directs the Hormone Therapy Clinic for aging male and female veterans at the New Orleans VA Medical Center (VAMC). He is also the principal investigator of the NIH-sponsored Center of Biomedical Research Excellence in Sex-Based Precision Medicine and leads the Hormones & Metabolism Discovery Research Laboratory at Tulane University School of Medicine. Previously, he led major federally funded research programs at Baylor College of Medicine, and Northwestern University. His contributions have earned him election to the American Society for Clinical Investigation and the Association of American Physicians.

Table of Contents

1. Introduction.- Part I: Menopausal hormone therapy in women.- 2. Consequences of oestradiol deficiency in menopausal women.- 3. Menopausal hormone therapy and prevention of chronic disease.- 4. Menopausal hormone therapy in primary care. Benefits, risks, and how to tailor the dose.- 5. Menopausal hormone therapy and prevention of cardiovascular disease.- 6. Menopausal hormone therapy and diabetes.- 7. Menopausal hormone therapy and cognition: An opportunity for precision medicine.- 8. Menopause hormone therapy in chronic auto-immune, pulmonary, and neurodegenerative diseases.- 9. Current concepts in menopausal hormone therapy and breast cancer.- 10. Progesterone and progestins in women’s health.- 11. Testosterone therapy in menopausal women with sexual dysfunction: 1940-2024.- 12. Testosterone therapy and metabolic health in menopausal women.- Part II. Testosterone therapy in hypogonadal men.- 13. Impact of testosterone deficiency and therapy on men’s health.- 14. History of testosterone therapy in men with testosterone deficiency.- 15. Testosterone therapy in men with functional hypogonadism.- 16. Male testosterone deficiency and therapy in primary care.- 17. Long-term effects of testosterone therapy in men with testosterone deficiency.- 18. Hypogonadism in men with obesity and diabetes.- 19. Testosterone therapy and prevention of type 2 diabetes in men with hypogonadism.- 20. Testosterone therapy and cardiovascular health.- 21. Testosterone therapy and the prostate.- 22. Benefits of testosterone therapy on mood and well-being.- 23. Testosterone deficiency and benefits of testosterone therapy in male veterans.- Part III. Thyroid and growth hormone therapy.- 24. Precision thyroid hormone therapy for hypothyroidism.- 25. Growth hormone deficiency and therapy during aging.