Principles of Process Research and Chemical Development in the Pharmaceutical Industry / Edition 1

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Overview

This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.

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Editorial Reviews

Booknews
An aid to help newcomers to the pharmaceutical industry shorten the time necessary to acquire expertise in chemical development. Discusses the goals and basic principles of chemical development, the crucial aspects of a new process that must be considered when scaling up a research synthesis to industrial levels, and case studies and vignettes to demonstrate each phase of the process. Also describes techniques for minimizing impurities, criteria for the cost-effective synthesis of enantio-pure compounds by resolutions, asymmetric synthesis and the chiral-pool strategy, new drug registration requirements, and other aspects. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780471165163
  • Publisher: Wiley
  • Publication date: 1/5/1998
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 240
  • Product dimensions: 6.36 (w) x 9.47 (h) x 0.63 (d)

Table of Contents

The Ideal.

Impure Thoughts.

Going All the Way.

Resolutions.

Mirrors.

Au Naturel.

Radiant.

License.

The Future.

Index.

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