Principles of Regenerative Medicine / Edition 2

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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

• Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
• The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
• New discoveries from leading researchers on restoration of diseased tissues and organs

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Product Details

  • ISBN-13: 9780123814227
  • Publisher: Elsevier Science
  • Publication date: 12/21/2010
  • Edition number: 2
  • Pages: 1202
  • Product dimensions: 8.80 (w) x 11.00 (h) x 1.80 (d)

Meet the Author

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazinès Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Robert Lanza, M.D. is currently Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor of Surgical Sciences at Wake Forest University School of Medicine. He has several hundred scientific publications and patents, and over 30 books, including Principles of Tissue Engineering (1st through 4th Editions), Methods of Tissue Engineering, Principles of Cloning (1st and 2nd Editions), Essentials of Stem Cell Biology (1st and 2nd Editions), XENO, Yearbook of Cell & Tissue Transplantation, One World: The Health & Survival of the Human Species in the 21st Century (as editor, with forewords by C. Everett Koop and former President Jimmy Carter), and Medical Science & the Advancement of World Health. Dr. Lanza received his B.A. and M.D. degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He is a former Fulbright Scholar, and studied as a student in the laboratory of Richard Hynes (MIT), Jonas Salk (The Salk Institute), and Nobel laureates Gerald Edelman (Rockefeller University) and Rodney Porter (Oxford University). He also worked closely (and coauthored a series of papers) with the late Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza's current area of research focuses on the use of stem cells in regenerative medicine.

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Table of Contents

1 Molecular Organization of Cells 2 Cell-ECM interactions In Repair and Regeneration 3Developmental Mechanisms of Regeneration 4The molecular basis of pluripotency in Principles of Regenerative Medicine 5How cells change their phenotype 6Scarless Wound Healing 7Somatic Cloning and Epigenetic Reprogramming in Mammals 8Engineered Proteins for Manipulating Gene Expression and Genome Sequence 9Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives 10Embryonic Stem Cells: Derivation and Properties 11Alternate Sources of human embryonic stem cells 12Stem cells derived from amniotic fluid and placenta 13Induced Pluripotent stem cells 14Mesenchymal Stem cells Derived from Bone Marrow 15Multipotent adult progenitor cells 16Mesenchymal Stem cells 17Hepatic Stem Cells and Therapy 18Cardiac stem cells 19Skeletal muscle stem cells 20Stem Cells Derived from Fat 21Stem Cells Derived from Peripheral Blood 22Islet Cell Therapy and Pancreatic Stem Cells 23Regenerative Medicine for Diseases of the Retina 24Somatic cells: Growth and expansion potential of T Lymphocytes 25Mechanical Determinants of Tissue Development 26Morphogenesis and Morphogenic Proteins 27Physical stress as a factor in tissue growth and remodeling 28Intelligent Surfaces for Cell Sheet Engineering 29Applications of Nanotechnology in Regenerative Medicine 30Design Principles in Biomaterials and Scaffolds 31Natural Origin Materials- Processing, Modification and Performance 32Synthetic Polymers 33Collagen Based Scaffold Materials 34Hydrogels 35Surface Modification of Biomaterials 36Histogenesis in Three-Dimensional Scaffolds 37Biocompatibility and Bioresponse to biomaterials 38Mechano-inducible systems for stem cells 39Biomineralization and Bone Regeneration 40Cell therapy for blood substitutes 41Articular Cartilage 42Implantation of Myogenic Cells in Skeletal Muscles 43Clinical islet transplantation 44Fetal Tissues 45Engineering of Large Diameter Vessels 46Engineering of Small Diameter Vessels 47Cardiac Tissue 48Regenerative Medicine in the Cornea 49Alimentary Tract 50Extracorporeal Kidney Support 51Tissue Engineering of the Reproductive System 52Cartilage Tissue Engineering 53Functional Tissue Engineering of Ligament and Tendon Injuries 54Central Nervous System 55Peripheral Nervous System

56 Tissue Engineeing of Skin 57Tissue Engineering of the Respiratory Tree 58Ethical Considerations 59US Stem Cell Research Policy 60Overview of FDA Regulatory Process

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