Principles of Tissue Engineering / Edition 1

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First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system.

This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.

The book contains black-and-white illustrations.

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Product Details

  • ISBN-13: 9780124366251
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 1/28/1997
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 808
  • Product dimensions: 8.79 (w) x 11.24 (h) x 1.99 (d)

Table of Contents

1 The Challenge of Tissue Engineering 1
2 Organization of Cells Into Higher Ordered Structures: The Role of the Epithelial-Mesenchymal Transformation in the Generation and Stabilization of Embryonic Tissues 9
3 The Dynamics of Cell-ECM Interactions with Implications for Tissue Engineering 23
4 Matrix Molecules and Their Ligands 47
5 Illustrations of Inductive Phenomena: Recent Developments in Mesoderm and Neural Induction 67
6 Gene Expression, Cell Determination and Differentiation 79
7 Mechanochemical Switching between Growth and Differentiation by Extracellular Matrix 89
8 Animal Cell Culture 101
9 Regulation of Cell Behavior by Extracellular Proteins 111
10 Growth Factors 133
11 Tissue Culture Bioreactors: Chondrogenesis as a Model System 151
12 In Vivo Synthesis of Tissues and Organs 169
13 Organotypic and Histiotypic Models 181
14 Quantitative Aspects of Tissue Engineering: Basic Issues in Kinetics, Transport and Mechanics 193
15 Using Self-Assembled Monolayers to Study the Interactions of Man-Made Materials with Proteins 211
16 Cell Interactions with Polymers 225
17 Matrix Effects 247
18 Polymer Scaffold Processing 263
19 Biodegradable Polymers for Tissue Engineering 273
20 Approaches to Transplanting Engineered Cells and Tissues 297
21 Immunomodulation of Islet Transplantation: Future Prospects 309
22 Immunoisolation 323
23 Design Considerations in Immunoisolation 333
24 Blood Vessels 349
25 Cardiac Prostheses 365
26 Cornea 383
27 Endocrinology: Pancreas 405
28 Parathyroid 427
29 Tissue Engineering Neointestine 441
30 Extracorporeal Artificial Liver Support 463
31 Stem Cell/Lineage Biology and Lineage-Dependent Extracellular Matrix Chemistry: Keys to Tissue Engineering of Quiescent Tissues Such as Liver 481
32 Red Blood Cell Substitutes Based on Modified Hemoglobin 517
33 Lymphocyte Engineering, Its Status of Art and Its Future 527
34 Tissue Engineering of the Hematopoietic Stem Cell 563
35 Application of Cell and Gene Therapies in the Tissue Engineering of Renal Replacement Devices 577
36 Tissue Engineering: Genitourinary System 591
37 Cell and Molecular Engineering of Bone Regeneration 603
38 Bone and Cartilage Reconstruction 619
39 Tendons and Ligaments 639
40 Mechanosensory Mechanisms In Bone 645
41 Hearing Assistance 663
42 Strategies for the Engineering of Peripheral Nervous Tissue Regeneration 671
43 Transplantation in the Spinal Cord 685
44 Tissue Engineering: Periodontal Applications 709
45 Regeneration of Dentin 727
46 Wound Repair: Lessons for Tissue Engineering 737
47 Skin and Epithelia 769
48 Plant Biotechnology 785
Index 799
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