Problem-Based Immunology / Edition 1

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Overview

It's one thing to understand the basic science of immunology. It's another thing to know how that science applies to the realities of patient care. This new resource uses skillfully presented clinical case studies to efficiently demonstrate the practical relevance of immunology knowledge in diagnosing a wide range of challenging conditions. It offers as an ideal way to review the fundamental principles of immunology ... and see them translated into real-world diagnosis and management!
  • Covers each major area of the field - immunization, hypersensitivity, autoimmunity, immunodeficiency disorders, tumor immunology, and transplantation.
  • Provides a concise overview of the basic concepts in each area, followed by 6-10 succinct and well-organized case studies that illustrate the associated clinical applications.
  • Begins each case study with an initial case presentation, complete with full-color clinical photographs, allowing you to put your diagnostic reasoning skills to the test - followed by a list of the key clinical features involved in the case · a one-paragraph discussion of each differential diagnostic possibility · and a summary of the correct diagnosis and treatment approach
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Editorial Reviews

From The Critics
Reviewer: Jane Peake, FRACP, DTM&H, M (University of Queensland)
Description: In few areas of medicine has the scientific understanding of underlying pathological processes expanded as quickly as it has in the area of immunology. This makes it difficult for medical students and clinicians to keep abreast of these findings and, in particular, to grasp their clinical relevance. This book is designed to provide an up-to-date understanding in immunology, both of the basic concepts and of clinical applications. Case scenarios are used to provide relevance and to increase interest and illustrate the broad spectrum of clinical immunology disorders.
Purpose: The purpose is to cover the basic science of immunology and, using the problem-based approach, provide the bridge with clinical medicine. Each section presents clinical case studies to demonstrate the practical relevance of immunology knowledge in diagnosing a variety of complex clinical disorders.
Audience: This book is designed for medical students and postgraduate students wanting to learn more about clinical immunology. It may also be of interest to those teaching these students as it provides problems and suggested group discussion topics which can be used to stimulate teaching.
Features: Sections cover each major area in the field of clinical immunology — immunodeficiency, hypersensitivity, autoimmunity, tumor immunology, transplantation, and immunization. Each section contains an overview of the main concepts and then a number of relevant case studies. Each of the case studies starts with a clinical vignette and then poses a number of questions for group discussion. The case is then further explored with analysis of the family history, laboratory investigations, differential diagnosis and, as relevant, further explanation regarding investigations, laboratory result interpretation, therapy, or underlying disease process and etiology. An interesting and unique addition to this book is the final section on psychoneuroimmunobiology, which explores the concept that the immune system is influenced by nonimmunological physiological systems and the interplay between mind and body.
Assessment: This is an excellent basic textbook for medical students and postgraduate students in clinical immunology. Students often have difficulty understanding both the complex science that underpins immunology and the clinical relevance of what they are learning. The design of the book stimulates the student into thinking about the scientific concepts and the cases provide clinical relevance and interest. If used as designed, by starting with the initial discussion questions before proceeding with the case, the student will be engaged in a way that they will want to continue to read more. In the developed world, allergic disease is becoming an increasing problem with rapid increases in the incidence of food allergy, allergic rhinitis, and eczema. The hypersensitivity section would have benefited from having cases that explored these important topics. A further reading section at the end of each case or section would have provided resources for students whose interest has been piqued. Unfortunately, this was only available for the psychoneuroimmunobiology section.
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Product Details

  • ISBN-13: 9781416024163
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/23/2006
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 268
  • Product dimensions: 7.90 (w) x 9.90 (h) x 0.50 (d)

Table of Contents

IMMUNIZATION

Background

• Rationale for immunization
• General principles of immunization
• Broad classes of vaccines
• Role of adjuvants
• Vaccine efficacy and safety
• Vaccine strategies in development
• Novel vaccine applications

Cases

1. Deliberate natural immunization (Leishmania)
2. Immunization in the bioterrorist era; small pox (or anthrax)
3. Immunization in the elderly (influenza)
4. Passive immunization: tetanus toxoid
5. Novel approaches for HIV vaccines
6. Polio vaccines- Salk versus Sabin
7. Cancer vaccine

HYPERSENSITIVITY

Background

• General principles
• Gell and Coombs classifications
• Sensitization and effector phases of Types I-IV hypersensitivity reactions

Cases

8. Anaphylaxis
9. Asthma
10. Transfusion reaction
11. Hemolytic disease of the newborn
12. Serum sickness
13. Farmer’s lung
14. Tuberculosis
15. Poison Ivy dermatitis

AUTOIMMUNITY

Background

• General principles of tolerance induction
• Current evidence/hypothesis for loss of tolerance
• Evidence supporting a role for genetics in autoimmune disorders
• Immunopathology associated with autoreactive antibodies
• Immunopathology associated with T cell mediated damage

Cases

16. Rheumatoid arthritis
17. Systemic lupus erythematosus
18. Graves’ disease
19. Wegener’s granulomatosis
20. Insulin dependent diabetes mellitus
21. Myasthenia gravis
22. Multiple sclerosis
23. Hashimoto’s thyroiditis

IMMUNODEFICIENCY DISORDERS

Background

• General principles of primary and secondary immunodeficiency disorders
• Dysfunctions that lead to primary immunodeficiency disorders affecting (a) T cells and B cells combined, (b) T cells, (c) B cells, (d) Complement, (e) phagocytes
• Conditions that lead to secondary immunodeficiencies

Cases

24. Severe combined immunodeficiency disorder
25. DiGeorge’s syndrome
26. Chronic mucocutaneous candidiasis
27. Bruton’s agammaglobuliniemia (hypogammaglobulinemia)
28. Selective IgA deficiency
29. Hyper IgM syndrome
30. Chromic granulomatous disease
31. Hereditary neurotic angioedema
32. C3 complement deficiency or (C8 complement deficiency)
33. Leukocyte adhesion defect
34. Acquired immunodeficiency disorder
35. Alcoholism and secondary immunodeficiency

TUMOR IMMUNOLOGY

Background

• General principles of tumor immunology
• Tumor specific antigens
• Tumor associated antigens
• Immunosurveillance mechanisms for eliminating tumors
• Evasion of immunosurveillance
• Novel therapies

Cases

36. Choriocarcinoma (?HCG )
37. Colonic carcinoma (CEA)
38. Melanoma
39. Multiple myeloma
40. Waldenstrom’s macroglobulinemia
41. Hodgkin’s lymphoma
42. Liver (or testicular) tumor (AFP)

TRANSPLANTATION

Background

• General Features
• Surgical and ischemia/reperfusion damage
• Role of activated tissue macrophages and activated vascular endothelial cells
• Adaptive immunity in graft rejection
• Tissue matching
• Non specific Immunosuppression
• Specific Immunosuppression

Cases

43. Intestinal transplant
44. Pancreas transplant
45. Kidney transplant
46. Bone marrow transplant
47. Heart (or Liver) transplant

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