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First published in 1979, this is an essential text for all who prescribe or monitor the effects of drug therapy on the fetus, neonate, infant, child, or adolescent. The previous edition, published in 1995, won an American Journal of Nursing Book of the Year Award in the category of pediatric nursing. The new, thoroughly referenced edition is an extensive update of the 12 chapters of the third edition, and a chapter is added on pediatric pharmacogenetics and pediatric chemotherapy. The editors, who have published collaboratively and individually several hundred professional and research articles plus several books, retained a multidisciplinary Pediatric Advisory Committee to ensure accuracy, timeliness, and comprehensiveness.
| Preface | xi | |
| Acknowledgments | xiii | |
| Contributing Authors | xv | |
| Pediatric Advisory Committee | xvii | |
| 1. | Administering Drugs to Infants, Children, and Adolescents | 1 |
| Drug Administration | 2 | |
| General Developmental Considerations for Drug Administration (Table) | 3 | |
| Special Considerations | 6 | |
| Oral Dosage Forms | 7 | |
| Rectal Dosage Forms | 19 | |
| Vaginal Dosage Forms | 22 | |
| Ophthalmic Dosage Forms | 23 | |
| Otic Dosage Forms | 27 | |
| Intranasal Dosage Forms | 28 | |
| Inhalation Dosage Forms | 31 | |
| Topical Dosage Forms | 36 | |
| Injectable Dosage Forms | 42 | |
| 2. | Drugs as Human Teratogens and Fetotoxins | 87 |
| Maternal Pharmacotherapy and Other Drug Use during Pregnancy | 88 | |
| Factors Affecting Teratogenesis | 89 | |
| Teratogenesis Drug Monographs | 96 | |
| 3. | Drugs Excreted in Human Breast Milk | 201 |
| Absorption | 202 | |
| Metabolism and Excretion | 202 | |
| Drugs Excreted in Human Breast Milk (Table) | 203 | |
| 4. | Pediatric Poisoning | 245 |
| General Considerations | 247 | |
| Treatment of Common Pediatric Poisonings | 253 | |
| 5. | Adverse Drug Reactions in Neonates, Infants, Children, and Adolescents | 283 |
| Classification of ADRs | 283 | |
| Risk Factors | 284 | |
| Establishing ADRs | 285 | |
| Drugs Commonly Required by Infants, Children, and Adolescents: Associated ADRs and Clinical Comments (Table) | 291 | |
| 6. | Pediatric Drug Interactions | 315 |
| Sites of Drug Interactions | 315 | |
| Drug Interactions and QT Prolongation | 316 | |
| Drug Interactions Involving Hepatic Cytochrome P-450 Isoenzymes (Table) | 317 | |
| Drug Interactions in Pediatric Patients | 319 | |
| 7. | Abusable Psychotropic Use among Children and Adolescents | 347 |
| Interactive Model of Abusable Psychotropic Use | 349 | |
| Abusable Psychotropic Variables | 354 | |
| Pattern-of-Use Variables | 370 | |
| Treatment | 373 | |
| 8. | Intravenous Drugs for Neonates, Infants, Children, and Adolescents: Preparation, Storage, and Administration | 387 |
| General Considerations | 387 | |
| Intravenous Drug Administration Guidelines for Infants and Children (Table) | 390 | |
| 9. | Pediatric Immunizations | 433 |
| General Cautions | 433 | |
| Active Immunization Schedules and Monographs for Vaccines and Toxoids | 437 | |
| 10. | Pediatric Pharmacokinetics | 459 |
| Pharmacokinetic Factors and Drug Effect | 459 | |
| Pharmacokinetic Principles | 463 | |
| Altered Pharmacokinetics in Disease States and with Concurrent Drug Therapy | 468 | |
| 11. | Pediatric Pharmacogenetics | 475 |
| Pharmacogenetic Principles | 475 | |
| 12. | Pediatric Antineoplastic Drug Therapy | 493 |
| Pediatric Considerations | 495 | |
| Guidelines for Use | 501 | |
| Antineoplastic Drug Dosing for Children and Adolescents (Table) | 507 | |
| 13. | Drug Dosing for Neonates | 531 |
| Recommended Drug Dosing for Neonates (Table) | 532 | |
| 14. | Drug Dosing for Infants, Children, and Adolescents | 555 |
| Drug Dosages for Infants, Children, and Adolescents | 556 | |
| Recommended Drug Dosing for Infants, Children, and Adolescents (Table) | 558 | |
| Appendices | 779 | |
| Appendix A | Abbreviations and Symbols | 781 |
| Appendix B | Normal Pediatric Laboratory Values | 785 |
| Index | 789 |
Overview
First published in 1979, this is an ...