Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate / Edition 2

Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate / Edition 2

by Kumar Gadamasetti
     
 

ISBN-10: 0849390516

ISBN-13: 9780849390517

Pub. Date: 11/16/2007

Publisher: Taylor & Francis

The second installment of Process Chemistry in the Pharmaceutical Industry enhances coverage of regulatory issues, crystallization, new technologies, automation, outsourcing, and future trends. Readers will gain insight into the multi-faceted challenges that process scientists face in tackling synthetic tasks under a regulatory framework. This book explains safety

Overview

The second installment of Process Chemistry in the Pharmaceutical Industry enhances coverage of regulatory issues, crystallization, new technologies, automation, outsourcing, and future trends. Readers will gain insight into the multi-faceted challenges that process scientists face in tackling synthetic tasks under a regulatory framework. This book explains safety methods and design experiments while also analyzing time-to-market schedules and the consequences of accelerating the development process. Clarifying the misinterpretation of process chemistry as mere scale-up work, this text also explores specifications for rigorous new uses of physical and analytical chemistry in refining drugs.

Product Details

ISBN-13:
9780849390517
Publisher:
Taylor & Francis
Publication date:
11/16/2007
Edition description:
REV
Pages:
520
Product dimensions:
7.10(w) x 10.10(h) x 1.30(d)

Table of Contents

Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever-Changing Climate—An Overview; K. Gadamasetti
Emerging Trends in Process Chemistry; T.F. Braish, F. De Knaep, and K. Gadamasetti
Varenicline: Discovery Synthesis and Process Chemistry Developments; J.W. Coe, H.A. Watson Jr., and R.A. Singer
The SUTENT® Story; R. Vaidyanathan
An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist; C. Savarin, J. Chung, J.A. Murry, R.J. Cvetovich, C. McWilliams, D. Hughes, J. Amato, G. Boice, K. Conrad, E. Corley, R. Reamer, and L. DiMichele
Process Research and Development of LY414197, a 5HT2B Antagonist; A. Borghese and A. Merschaert
To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant; H. J.Federsel and A. Sveno
Chiral Amine Synthesis—Strategies, Examples, and Limitations; T.C. Nugent
Unnatural Amino Acids; D.J. Ager
The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862; C.P. Ashcroft, S. Challenger, A.M. Derrick, Y. Hajikarimian, and N.M. Thomson
Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals; T. Norris
The Lithium–Halogen Exchange Reaction in Process Chemistry; W.F. Bailey and T.L. Rathman
Oxetan-3-one: Chemistry and Synthesis; G. Wuitschik, E.M. Carreira, M. Rogers-Evans, and K. Müller
Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions; O. Navarro and S.P. Nolan
Toward Truly Efficient Organic Reactions in Water; C. Ogawa and S. Kobayashi
The Chemical Development of the Commercial Route to Sildenafil Citrate; P.J. Dunn
Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds; R.L. Hanson
Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science; D. Wieckhusen
In Situ Mid-Infrared Spectroscopy for Process Development; D.A. Conlon, W. Izzo, J. Christopher McWilliams, R.A. Reamer, F. Xu, and P. Collins
Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Reaction; J.C. McWilliams and R.A. Reamer
Development of Efficient One-Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism; F. Xu
Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend®); D.A. Conlon, W. Izzo, and P. Collins
Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals—Promise, Practice, and Challenges; C.A. Mojica and L. St. Pierre-Berry
PEGylation of Biological Macromolecules; J.J. Buckley, R.F. Finn, J. Mo, L.A. Bass, and S.V. Ho
Microwave Technology in Process Optimization; F. Mavandadi
Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture;
S. Casnocha, R. Fedechko, P. Mensah, J. Mott, and S. Nema
Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps; N. Zotova, S.P. Mathew, H. Iwamura, and D.G. Blackmond
Trends in Outsourcing; J. Lu and I. Shinkai
Sourcing Pharmaceutical Products in China and India; D. Robins and S. Hannon Index

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