Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate / Edition 2

Hardcover (Print)
Buy New
Buy New from BN.com
$300.00
Used and New from Other Sellers
Used and New from Other Sellers
from $292.48
Usually ships in 1-2 business days
(Save 2%)
Other sellers (Hardcover)
  • All (5) from $292.48   
  • New (3) from $292.48   
  • Used (2) from $299.99   

Overview

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic, physical, and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercializing drug candidates.

The second installment in this progressive series, this volumereviews the latest breakthroughs to advance process chemistry, including asymmetric synthesis, crystallization, morphology, enzymatic intervention, green chemistry, macromolecules (monoclonal antibodies, biological molecules, polymers), enantioselectivity, organometallic chemistry, process analytical tools, chemical engineering controls, regulatory compliance, and outsourcing/globalization. It explores new approaches to synthetic processes, examines the latest safety methods and experiment design, and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy, ease of synthesis, instrumentation, automization, quality control, cost considerations, green practices, and future trends.

Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions byreputed scientists, technologists, engineers, and professors from leading academic institutions, such as the Imperial College, UK, the University of Tokyo, ETH, Switzerland, the International University at Bermen, Germany, and the University of Connecticut, USA, and from principal pharmaceutical companies that include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly, Astrazeneca and DSM.

Read More Show Less

Product Details

  • ISBN-13: 9780849390517
  • Publisher: CRC Press
  • Publication date: 11/16/2007
  • Edition description: REV
  • Edition number: 2
  • Pages: 520
  • Product dimensions: 7.10 (w) x 10.10 (h) x 1.30 (d)

Table of Contents

Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever-Changing Climate—An Overview; K. Gadamasetti
Emerging Trends in Process Chemistry; T.F. Braish, F. De Knaep, and K. Gadamasetti
Varenicline: Discovery Synthesis and Process Chemistry Developments; J.W. Coe, H.A. Watson Jr., and R.A. Singer
The SUTENT® Story; R. Vaidyanathan
An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist; C. Savarin, J. Chung, J.A. Murry, R.J. Cvetovich, C. McWilliams, D. Hughes, J. Amato, G. Boice, K. Conrad, E. Corley, R. Reamer, and L. DiMichele
Process Research and Development of LY414197, a 5HT2B Antagonist; A. Borghese and A. Merschaert
To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant; H. J.Federsel and A. Sveno
Chiral Amine Synthesis—Strategies, Examples, and Limitations; T.C. Nugent
Unnatural Amino Acids; D.J. Ager
The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862; C.P. Ashcroft, S. Challenger, A.M. Derrick, Y. Hajikarimian, and N.M. Thomson
Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals; T. Norris
The Lithium–Halogen Exchange Reaction in Process Chemistry; W.F. Bailey and T.L. Rathman
Oxetan-3-one: Chemistry and Synthesis; G. Wuitschik, E.M. Carreira, M. Rogers-Evans, and K. Müller
Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions; O. Navarro and S.P. Nolan
Toward Truly Efficient Organic Reactions in Water; C. Ogawa and S. Kobayashi
The Chemical Development of the Commercial Route to Sildenafil Citrate; P.J. Dunn
Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds; R.L. Hanson
Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science; D. Wieckhusen
In Situ Mid-Infrared Spectroscopy for Process Development; D.A. Conlon, W. Izzo, J. Christopher McWilliams, R.A. Reamer, F. Xu, and P. Collins
Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Reaction; J.C. McWilliams and R.A. Reamer
Development of Efficient One-Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism; F. Xu
Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend®); D.A. Conlon, W. Izzo, and P. Collins
Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals—Promise, Practice, and Challenges; C.A. Mojica and L. St. Pierre-Berry
PEGylation of Biological Macromolecules; J.J. Buckley, R.F. Finn, J. Mo, L.A. Bass, and S.V. Ho
Microwave Technology in Process Optimization; F. Mavandadi
Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture;
S. Casnocha, R. Fedechko, P. Mensah, J. Mott, and S. Nema
Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps; N. Zotova, S.P. Mathew, H. Iwamura, and D.G. Blackmond
Trends in Outsourcing; J. Lu and I. Shinkai
Sourcing Pharmaceutical Products in China and India; D. Robins and S. Hannon Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)