Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate / Edition 2

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The second installment of Process Chemistry in the Pharmaceutical Industry enhances coverage of regulatory issues, crystallization, new technologies, automation, outsourcing, and future trends. Readers will gain insight into the multi-faceted challenges that process scientists face in tackling synthetic tasks under a regulatory framework. This book explains safety methods and design experiments while also analyzing time-to-market schedules and the consequences of accelerating the development process. Clarifying the misinterpretation of process chemistry as mere scale-up work, this text also explores specifications for rigorous new uses of physical and analytical chemistry in refining drugs.

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Product Details

  • ISBN-13: 9780849390517
  • Publisher: Taylor & Francis
  • Publication date: 11/16/2007
  • Edition description: REV
  • Edition number: 2
  • Pages: 520
  • Product dimensions: 7.10 (w) x 10.10 (h) x 1.30 (d)

Table of Contents

Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever-Changing Climate—An Overview; K. Gadamasetti
Emerging Trends in Process Chemistry; T.F. Braish, F. De Knaep, and K. Gadamasetti
Varenicline: Discovery Synthesis and Process Chemistry Developments; J.W. Coe, H.A. Watson Jr., and R.A. Singer
The SUTENT® Story; R. Vaidyanathan
An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist; C. Savarin, J. Chung, J.A. Murry, R.J. Cvetovich, C. McWilliams, D. Hughes, J. Amato, G. Boice, K. Conrad, E. Corley, R. Reamer, and L. DiMichele
Process Research and Development of LY414197, a 5HT2B Antagonist; A. Borghese and A. Merschaert
To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant; H. J.Federsel and A. Sveno
Chiral Amine Synthesis—Strategies, Examples, and Limitations; T.C. Nugent
Unnatural Amino Acids; D.J. Ager
The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862; C.P. Ashcroft, S. Challenger, A.M. Derrick, Y. Hajikarimian, and N.M. Thomson
Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals; T. Norris
The Lithium–Halogen Exchange Reaction in Process Chemistry; W.F. Bailey and T.L. Rathman
Oxetan-3-one: Chemistry and Synthesis; G. Wuitschik, E.M. Carreira, M. Rogers-Evans, and K. Müller
Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions; O. Navarro and S.P. Nolan
Toward Truly Efficient Organic Reactions in Water; C. Ogawa and S. Kobayashi
The Chemical Development of the Commercial Route to Sildenafil Citrate; P.J. Dunn
Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds; R.L. Hanson
Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science; D. Wieckhusen
In Situ Mid-Infrared Spectroscopy for Process Development; D.A. Conlon, W. Izzo, J. Christopher McWilliams, R.A. Reamer, F. Xu, and P. Collins
Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Reaction; J.C. McWilliams and R.A. Reamer
Development of Efficient One-Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism; F. Xu
Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend®); D.A. Conlon, W. Izzo, and P. Collins
Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals—Promise, Practice, and Challenges; C.A. Mojica and L. St. Pierre-Berry
PEGylation of Biological Macromolecules; J.J. Buckley, R.F. Finn, J. Mo, L.A. Bass, and S.V. Ho
Microwave Technology in Process Optimization; F. Mavandadi
Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture;
S. Casnocha, R. Fedechko, P. Mensah, J. Mott, and S. Nema
Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps; N. Zotova, S.P. Mathew, H. Iwamura, and D.G. Blackmond
Trends in Outsourcing; J. Lu and I. Shinkai
Sourcing Pharmaceutical Products in China and India; D. Robins and S. Hannon Index

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