Process development in antibiotic fermentation is of microbiological and commercial importance and this book gives a consistent treatment of the area.
Table of Contents
Preface; Part I. Background: 1. Introduction; 2. The microorganisms and methods of culture; 3. Microbial physiology; 4. Microbial biochemistry; 5. Subsidiary factors important in production fermentations; 6. Submerged culture conditions: the interaction between environment and genotype; Part II. Process Development in the Laboratory: 7. Laboratory fermentation process development; 8. Assessment and understanding of experimental results; 9. Strain improvement; 10. Methods for laboratory process development; Part III. Industrial Fermentation Plants and Pilot Plants: 11. Fermentation plants and pilot plants; 12. Process development in the fermentation plant; 13. Two plant problems: infection and variations in the level of production; Postscript; Bibliography; References; Index.
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