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Doody's Review ServiceReviewer: Dixon B. Kaufman, MD (Northwestern University Feinberg School of Medicine)
Description: This monograph describes the various approaches to the isolation of pancreatic islets from the whole pancreas in animals and man.
Purpose: The predominant purpose of the book is to describe the techniques of islet isolation from the whole pancreas for purposes of transplantation as a treatment of diabetes. There is a relative paucity of information combined a single monograph describing the various techniques, as applied to rodents, large animals, and humans. The book's objectives are met, although there is variability in detail among chapters. One obvious deficiency is that of the technique of islet isolation in primate models. Nevertheless, on a whole, it is one of the most complete monographs on this topic.
Audience: The book is primarily written for basic researchers and clinicians interested in the field of cellular transplantation and, specifically, islet cell transplantation, as well as researchers involved in the field of diabetes. The authors are credible authorities on the subject. The leaders in academics have contributed chapters on the topics.
Features: The book is somewhat austere in its features. In general, it is underillustrated, especially in demonstrating specific techniques, although there are some outstanding color photomicrographs depicting isolated islets. The references are current and pertinent. The table of contents and index are adequate.
Assessment: This is a unique monograph on a topic that will be of interest to a specialized group of researchers and clinicians. It is as up-to-date and as thorough an overview of the techniques of pancreatic islet procurement that has been written.