Procurement of Pancreatic Islets

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Editorial Reviews

Doody's Review Service
Reviewer: Dixon B. Kaufman, MD (Northwestern University Feinberg School of Medicine)
Description: This monograph describes the various approaches to the isolation of pancreatic islets from the whole pancreas in animals and man.
Purpose: The predominant purpose of the book is to describe the techniques of islet isolation from the whole pancreas for purposes of transplantation as a treatment of diabetes. There is a relative paucity of information combined a single monograph describing the various techniques, as applied to rodents, large animals, and humans. The book's objectives are met, although there is variability in detail among chapters. One obvious deficiency is that of the technique of islet isolation in primate models. Nevertheless, on a whole, it is one of the most complete monographs on this topic.
Audience: The book is primarily written for basic researchers and clinicians interested in the field of cellular transplantation and, specifically, islet cell transplantation, as well as researchers involved in the field of diabetes. The authors are credible authorities on the subject. The leaders in academics have contributed chapters on the topics.
Features: The book is somewhat austere in its features. In general, it is underillustrated, especially in demonstrating specific techniques, although there are some outstanding color photomicrographs depicting isolated islets. The references are current and pertinent. The table of contents and index are adequate.
Assessment: This is a unique monograph on a topic that will be of interest to a specialized group of researchers and clinicians. It is as up-to-date and as thorough an overview of the techniques of pancreatic islet procurement that has been written.
Dixon B. Kaufman
This monograph describes the various approaches to the isolation of pancreatic islets from the whole pancreas in animals and man. The predominant purpose of the book is to describe the techniques of islet isolation from the whole pancreas for purposes of transplantation as a treatment of diabetes. There is a relative paucity of information combined a single monograph describing the various techniques, as applied to rodents, large animals, and humans. The book's objectives are met, although there is variability in detail among chapters. One obvious deficiency is that of the technique of islet isolation in primate models. Nevertheless, on a whole, it is one of the most complete monographs on this topic. The book is primarily written for basic researchers and clinicians interested in the field of cellular transplantation and, specifically, islet cell transplantation, as well as researchers involved in the field of diabetes. The authors are credible authorities on the subject. The leaders in academics have contributed chapters on the topics. The book is somewhat austere in its features. In general, it is underillustrated, especially in demonstrating specific techniques, although there are some outstanding color photomicrographs depicting isolated islets. The references are current and pertinent. The table of contents and index are adequate. This is a unique monograph on a topic that will be of interest to a specialized group of researchers and clinicians. It is as up-to-date and as thorough an overview of the techniques of pancreatic islet procurement that has been written.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781570591334
  • Publisher: CRC Press
  • Publication date: 1/1/1994
  • Series: Medical Intelligence Unit
  • Edition number: 1
  • Pages: 187

Table of Contents

Foreword
Preface
1 Introduction 1
2 Engineering Issues in Islet Immunoisolation 13
3 Fundamentals of Microencapsulation 21
4 Microencapsulation as Bioartificial Organs: Allografts and Xenografts 45
5 Microencapsulation in Small Animals - Xenografts 59
6 Encapsulated Islet Transplantation: Pathway to Human Clinical Trials 81
7 Transplantation of Microencapsulated Human Islets in Nonimmunosuppressed Diabetic Patients 93
8 Insulin Release from Rat Pancreatic Islets Microencapsulated in a HEMA-MMA Polyacrylate 107
9 Macroencapsulation of Islets for the Treatment of Diabetes 119
10 Macroencapsulation in Small Animals 133
11 Macroencapsulation in Large Animals 139
12 Macroporous Devices for Diabetes Correction 147
13 Devices Implanted as AV Shunts 157
14 Relative Contributions of Diffusion and Ultrafiltration in a Vascular Bioartificial Pancreas 169
15 Biohybrid Devices: Future Considerations 175
Index 181
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