Prognostic and Predictive Value of p53: European School of Oncology Scientific Updates

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Editorial Reviews

This first volume in a series deals with one of the most important genes in the molecular genetics of human cancer, p53, a cellular protein. Since the discovery of the gene and its product in 1979, it has been discovered to be involved in cell cycle control, DNA repair, apoptosis, cellular differentiation, senescence and angiogenesis. This volume, arising from a meeting organized by the European School of Oncology in London in December 1996, addresses the structure, different functions, and interactions of p53; relationship of p53 alterations with other tumor characteristics; incidence and prognostic value of p53 alterations with respect to a spectrum of tumor types and patient subgroups; predictive value of p53 with respect to endocrine therapy, chemotherapy, and radiotherapy; discrepancies in results of studies using different techniques for measuring p53 mutations and alterations of the p53 pathway; p53 as a target for potential new treatments. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

Table of Contents

Introduction 1
The p53 tumour suppressor gene: from molecular biology to clinical investigation 3
Subgroups of p53 mutations may predict the clinical behaviour of cancers in the breast and colon and contribute to therapy response 23
Determination and use of p53 in the management of cancer patients, with special focus on breast cancer 35
Prognostic and predictive significance of p53 protein accumulation in human primary breast cancer analysed with a luminometric immunoassay (LIA) on tumour cytosols 51
p53 status: impact on breast tumour biology and response to therapy 63
The prognostic significance and interactions of p53 in human cancer 77
p53 protein expression in human breast cancer: relationship to tumour differentiation and endocrine response 95
p53 and angiogenesis in neoplasia 115
Prognostic and predictive value of p53 aberrations in tumours of the gastrointestinal tract and pancreas 131
p53 genotypes and haplotypes with a potentially predictive value for risk assessment and retroviral p53 transduction for gene therapy of breast cancer 143
Subject index 161
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