BooknewsThis first volume in a series deals with one of the most important genes in the molecular genetics of human cancer, p53, a cellular protein. Since the discovery of the gene and its product in 1979, it has been discovered to be involved in cell cycle control, DNA repair, apoptosis, cellular differentiation, senescence and angiogenesis. This volume, arising from a meeting organized by the European School of Oncology in London in December 1996, addresses the structure, different functions, and interactions of p53; relationship of p53 alterations with other tumor characteristics; incidence and prognostic value of p53 alterations with respect to a spectrum of tumor types and patient subgroups; predictive value of p53 with respect to endocrine therapy, chemotherapy, and radiotherapy; discrepancies in results of studies using different techniques for measuring p53 mutations and alterations of the p53 pathway; p53 as a target for potential new treatments. Annotation c. by Book News, Inc., Portland, Or.
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