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Doody's Review ServiceReviewer: Mary F. Mulcahy, MD (Northwestern University Feinberg School of Medicine)
Description: This is the third volume in a series exploring recent advances in cancer pathogenesis and treatment. A few specific topics are addressed in which progress either through clinical research, bench research, or epidemiologic studies have been made.
Purpose: The purpose is to present thought provoking information which may be applied to clinical practice and research. This aspect of oncology is not generally addressed in standard texts in any great depth. The editors are successful in illustrating the application of research, both basic and clinical, to clinical practice.
Audience: It is unclear for whom the editors intended this book. The topics covered and the level at which it is written would certainly be of interest to students, clinicians, researchers, and ethicists. The primary editor is unquestionably a credible authority, having made innumerable contributions to cancer treatment.
Features: This volume covers a wide range of topics. It opens with a unique chapter on the history and development of clinical research, IRBs, and informed consent. The future of breast cancer research is examined, as well as the ethics and issues regarding genetically determined breast cancer. The exciting field of angiogenesis inhibitors is explored, providing theoretical and practical rationale for clinical applications. Progress in lung cancer is addressed in regard to chemotherapy and surgical advances. The section on urologic tumors applauds the success in the treatment of testicular cancer, as well as the controversies in prostate cancer screening. Immunotherapy is discussed, covering both vaccines and interferon in the treatment of melanoma. Finally, the role of infectious agents in neoplasm is explored. The last section on advances in solid tumors applies some of these principles to less common, difficult to treat tumors.
Assessment: The editors of this book excel in their ability to translate scientific data into clinically relevant ideas. All of the conclusions drawn are based on reliable evidence. The progression of both bench and clinical research to changes and advances in medical practice are clearly evident. This book provides examples of exciting areas of progress in cancer treatment.