Proinflammatory and Antiinflammatory Peptides

by Sami I. Said (Editor)

Overview

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

Product Details

ISBN-13:	9780367400675
Publisher:	Taylor & Francis
Publication date:	09/23/2019
Series:	Lung Biology in Health and Disease
Edition description:	Reprint
Pages:	760
Product dimensions:	6.12(w) x 9.19(h) x (d)

Table of Contents

Part 1 Cell injury and inflammation: inflammation, cell injury and apoptosis; proinflammatory and antiinflammatory response cytokines in the inflammatory response. Part 1 Proinflammatory peptides: proinflammatory peptides in sensory nerves of the airways; sensory neuropeptides and bronchial hyperresponsiveness; the tachykinin family of peptides and their receptors; endothelins in inflammation; endothelins in the lung; proinflammatory peptides in relation to other inflammatory mediators; cellular regulation of kinin receptors - potential roles in inflammation. Part 3 Antiinflammatory peptides: modulation of inflammatory effects of cytokines by the neuropeptide -MSH; regulation of VIP gene expression; neuroregulation of pulmonary immune responses by VIP and substance P; role of vasoactive intestinal peptide in myocardial ischaemia - reperfusion injury; antiinflammatory actions of VIP in the lungs and airways; VIP regulation of neuronal proliferation and differentiation; implications for neuronal repair; neurotrophic action of VIP - from CNS ontogeny to therapeutic strategy. Part 4 Modulation of peptide action - therapeutic applications: long-acting VIP analogs; catalytic anti-VIP antibodies and their relevance to the airways; enzymatic degradation of bradykinin; enzymatic modulation of the tachykinins and VIP in the lung; therapeutic effects and immunomodulatory activities of natriuretic peptides.

Editorial Reviews

". . .a thorough and scholarly account of the diverse roles that peptides can play in inflammation. The move in inflammation research will be made familiar with the important concept that inflammation is controlled not only by pro-inflammatory factors but also, and perhaps more importantly, from a therapeutic perspective, by anti-inflammatory checks and messengers. The more advanced researcher is provided with comprehensive overviews of pro- and anti-inflammatory peptides."
—-Trends in Pharmacological Science

From the Publisher

This volume of the Lung Biology in Health and Disease series is a synopsis of current and authoritative information relative to peptides that can influence inflammation and cell injury in the lung. The purpose is to review peptides and their biologic functions including biochemistry, pharmacology, molecular biology, and therapeutic potential. These objectives are worthy and this book solidly meets these objectives. The book is written for basic scientists and subspecialty clinicians interested in the role of peptides in inflammation and tissue repair. The editors and chapter authors are internationally recognized experts in their fields. The diagrams and tables are useful and appropriate in number. The table of contents and index provide adequate guidance. The references are both relevant and current. The simple, attractive appearance of this book is characteristic of the series. This is a useful compendium of current, authoritative reviews of peptides that can influence tissue inflammation and cell injury as well as their analogs, agonists, and antagonists. It would be of interest to basic scientists and clinician subspecialists interested in peptides. Medical libraries would likely find it a useful reference.

Leslie C. Grammer

In 23 papers from a symposium sponsored by the Federation f American Societies or Experimental Biology (no date or location noted) analyzes the role of peptides in promoting or suppressing inflammation. They examine the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair; cytokines and inflammation, neuropeptides; endothelin and tachykinin peptides; peptide modulation and regulation; peptide chemistry and biochemistry; the pharmacology of peptide synthesis; enzymatic degradation; and other topics. Addressed to professionals and graduate students in any of a wide range of medical fields. Annotation c. by Book News, Inc., Portland, Or.

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