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Doody's Review ServiceReviewer: Robert J. Matusik, PhD (Vanderbilt University School of Medicine)
Description: This book on the prostate is organized into three parts, covering epidemiology, ontogeny and etiology, and diagnostic and therapeutic aspects of benign prostatic hyperplasia (BPH) and cancer of the prostate (CaP).
Purpose: The graying of the population will result in a tripling of the number people older than age of 60 by the year 2020, and because prostatic disease is found most frequently in men older than the age of 60, these epidemiological predictions have warranted new research in this area.
Audience: Students and basic and clinical researchers entering prostatic research will find that this book serves as a handy resource on the status of our knowledge.
Features: Dr. Naz has selected established investigators in the field of prostatic research to write individual chapters as part of this resource book. The authors present the normal prostatic development in the rodent and human where they present an excellent collection of illustrations. They consider the hormonal influences androgens and estrogen; the role of mutations in the androgen receptor in CaP; and the altered balance between proliferation and apoptosis in tumors. The last chapter discusses chemoprevention and both current and future therapeutic aspects of dealing with prostatic disease.
Assessment: This is a good resource on the prostrate that covers the anatomy, biochemical, and molecular biological changes that normally occur and the mechanisms that may be involved in developing BPH and CaP as well as in the progression of the cancer to the androgen nonresponsive state.