Protein Bioinformatics: An Algorithmic Approach to Sequence and Structure Analysis / Edition 1

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Bioinformatics is the study of biological information and biological systems - such as of the relationships between the sequence, structure and function of genes and proteins. The subject has seen tremendous development in recent years, and there are ever-increasing needs for good understanding of quantitative methods in the study of proteins. Protein Bioinformatics: An Algorithmic Approach to Sequence and Structure Analysis takes the novel approach of covering both the sequence and structure analysis of proteins in one volume and from an algorithmic perspective. Protein Bioinformatics: An Algorithmic Approach to Sequence and Structure Analysis is ideally suited for advanced undergraduate and graduate students of bioinformatics, statistics, mathematics and computer science. It also provides an excellent introduction and reference source on the subject for practitioners and researchers.
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Product Details

  • ISBN-13: 9780470848395
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 3/1/2004
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 380
  • Product dimensions: 6.48 (w) x 9.39 (h) x 1.06 (d)

Table of Contents

Pt. I Sequence Analysis
1 Pairwise Global Alignment of Sequences 3
2 Pairwise Local Alignment and Database Search 25
3 Statistical Analysis 47
4 Multiple Global Alignment and Phylogenetic Trees 65
5 Scoring Matrices 101
6 Profiles 123
7 Sequence Patterns 141
Pt. II Structure Analysis
8 Structures and Structure Descriptions 165
9 Superposition and Dynamic Programming 193
10 Geometric Techniques 211
11 Clustering: Combining Local Similarities 229
12 Significance and Assessment of Structure Comparisons 253
13 Multiple Structure Comparison 261
14 Protein Structure Classification 279
Pt. III Sequence-Structure Analysis
15 Structure Prediction: Threading 297
App. A Basics in Mathematics, Probability and Algorithms 315
App. B Introduction to Molecular Biology 323
References 337
Index 349
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