Protein Degradation: The Ubiquitin-Proteasome System / Edition 1

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Overview

Backed by the expertise of the worlds's leading protein degradationexperts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, latest results on novel members of the ubiquitin superfamily and their role in cellular regulation are presented here. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes,, as well as its pathophysiological disease states.

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Editorial Reviews

From the Publisher
"... a comprehensive chapter on the structure of large,self-compartmentalizing proteases ... gives an overview how complexthese 'molecular machines' are that keep our cells clean. Theindividual chapters are followed by extensive references, and thiswill quarantee immediate guided access to the important literature.In summary, the book provides much more than anyone could assemblefrom Pubmed in a meaningful way to get informed appropriately."
Zellbiologie aktuell

"The series - when completed - is likely to become a comprehensivework of reference on the ubiquitin/proteasome system."
ChemBioChem

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Product Details

  • ISBN-13: 9783527311309
  • Publisher: Wiley
  • Publication date: 4/21/2006
  • Series: Protein Degradation Series , #2
  • Edition number: 1
  • Pages: 300
  • Product dimensions: 6.85 (w) x 9.76 (h) x 0.77 (d)

Meet the Author

John Mayer obtained his MS and PhD degrees from the University ofBirmingham (UK). He is currently serving as Professor ofBiochemistry at the School of Biomedical Sciences at NottinghamUniversity.
For the past 30 years, he has investigated intracellularproteolysis and particularly the ubiquitin/proteasome system.Presently, he is particularly interested in intracellularproteolysis in relation to neurodegenerative illnesses.

Aaron Ciechanover obtained his MD from the Hebrew University inJerusalem (Israel), and his PhD from the Technion-Israel Instituteof Technology in Haifa, where he is presently serving as Professorof Biochemistry. Professor Ciechanover is known for his discoveryof the first ubiquitin system mutant cell, demonstrating the roleof the ubiquitin-proteasome proteolytic system in proteindegradation in vivo. In 2004, he has received the Nobel Prize inChemistry for his ground-breaking work on the ubiquitin-proteasomesystem.

Martin Rechsteiner is Professor of Biochemistry at the Universityof Utah in Salt Lake City (USA). He is interested in the proteasomecomponent of the ubiquitin-proteasome pathway. He has identifiedseveral key regulators of proteasome function and is currentlyworking on their structural and functional elucidation.

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Table of Contents

Degrons: signals and sites for ubiquitylation
The proteasome portal and regulation of proteolysis
PAN and the proteasome
Ubiquitin domain proteins
MEKK1: dual function as a protein kinase and a ubiquitin proteinligase
HECT domain ubiquitin protein ligases
UCRP: ubiquitin cross-reactive protein
SUMOs and their function in the cell
Functions of the ubiquitin-proteasome pathway
Molecular Chaperones and the ubiquitin/proteasome system
Dissecting intracellular proteolysis using small moleculeinhibitors and molecular probes
Electron microscopy of compartmentalised proteases
Molecular dissection of autophagy in yeast

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