Protein Degradation: The Ubiquitin-Proteasome System / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $159.02
Usually ships in 1-2 business days
(Save 39%)
Other sellers (Hardcover)
  • All (8) from $159.02   
  • New (5) from $168.01   
  • Used (3) from $159.02   


Backed by the expertise of the worlds's leading protein degradationexperts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, latest results on novel members of the ubiquitin superfamily and their role in cellular regulation are presented here. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes,, as well as its pathophysiological disease states.

Read More Show Less

Editorial Reviews

From the Publisher
"... a comprehensive chapter on the structure of large,self-compartmentalizing proteases ... gives an overview how complexthese 'molecular machines' are that keep our cells clean. Theindividual chapters are followed by extensive references, and thiswill quarantee immediate guided access to the important literature.In summary, the book provides much more than anyone could assemblefrom Pubmed in a meaningful way to get informed appropriately."
Zellbiologie aktuell

"The series - when completed - is likely to become a comprehensivework of reference on the ubiquitin/proteasome system."

Read More Show Less

Product Details

  • ISBN-13: 9783527311309
  • Publisher: Wiley
  • Publication date: 4/21/2006
  • Series: Protein Degradation Series , #2
  • Edition number: 1
  • Pages: 300
  • Product dimensions: 6.85 (w) x 9.76 (h) x 0.77 (d)

Meet the Author

John Mayer obtained his MS and PhD degrees from the University ofBirmingham (UK). He is currently serving as Professor ofBiochemistry at the School of Biomedical Sciences at NottinghamUniversity.
For the past 30 years, he has investigated intracellularproteolysis and particularly the ubiquitin/proteasome system.Presently, he is particularly interested in intracellularproteolysis in relation to neurodegenerative illnesses.

Aaron Ciechanover obtained his MD from the Hebrew University inJerusalem (Israel), and his PhD from the Technion-Israel Instituteof Technology in Haifa, where he is presently serving as Professorof Biochemistry. Professor Ciechanover is known for his discoveryof the first ubiquitin system mutant cell, demonstrating the roleof the ubiquitin-proteasome proteolytic system in proteindegradation in vivo. In 2004, he has received the Nobel Prize inChemistry for his ground-breaking work on the ubiquitin-proteasomesystem.

Martin Rechsteiner is Professor of Biochemistry at the Universityof Utah in Salt Lake City (USA). He is interested in the proteasomecomponent of the ubiquitin-proteasome pathway. He has identifiedseveral key regulators of proteasome function and is currentlyworking on their structural and functional elucidation.

Read More Show Less

Table of Contents

Degrons: signals and sites for ubiquitylation
The proteasome portal and regulation of proteolysis
PAN and the proteasome
Ubiquitin domain proteins
MEKK1: dual function as a protein kinase and a ubiquitin proteinligase
HECT domain ubiquitin protein ligases
UCRP: ubiquitin cross-reactive protein
SUMOs and their function in the cell
Functions of the ubiquitin-proteasome pathway
Molecular Chaperones and the ubiquitin/proteasome system
Dissecting intracellular proteolysis using small moleculeinhibitors and molecular probes
Electron microscopy of compartmentalised proteases
Molecular dissection of autophagy in yeast

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)