Protein Electrophoresis in Clinical Diagnosis

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"Since the publication of High-Resolution Electrophoresis and Immunofixation 2e, there have been ever-increasing advances in the analyses of proteins, by electrophoresis in particular. Protein Electrophoresis in Clinical Diagnosis shows the changes in both techniques and interpretation, presenting a comprehensive review of serum protein techniques, immunofixation techniques and pattern interpretation of serum, urine and cerebrospinal fluid. Conditions associated with Monoclonal Gammopathies are considered, as are the appropriate strategies for
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Overview

"Since the publication of High-Resolution Electrophoresis and Immunofixation 2e, there have been ever-increasing advances in the analyses of proteins, by electrophoresis in particular. Protein Electrophoresis in Clinical Diagnosis shows the changes in both techniques and interpretation, presenting a comprehensive review of serum protein techniques, immunofixation techniques and pattern interpretation of serum, urine and cerebrospinal fluid. Conditions associated with Monoclonal Gammopathies are considered, as are the appropriate strategies for their detection." Dr. Keren's book will once again become essential to every laboratory, and will be used by pathologists, chemical chemists, medical technologists and clinicians (particularly hematologists and oncologists).
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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is a comprehensive book on protein electrophoresis and clinical diagnosis. This is the fourth revision; the previous version was published in 2003.
Purpose: The purpose is to provide instruction on the use of protein electrophoresis of serum, urine, and cerebrospinal fluid in clinical diagnosis. These very worthy objectives are well met.
Audience: Although the author does not specify the intended audience, the previous version was directed at those who interpret electrophoresis gels. This version would appeal to this same audience (i.e., laboratory personnel performing and interpreting protein electrophoresis) as well as pathologists/laboratory medicine practitioners providing clinical consultation on these results and the broad base of "customers" who order these tests and want to better understand methodology, interpretation, and clinical use (e.g., medical students, primary care providers, clinical hematologists/oncologists, etc.). The author is a well-respected authority in this field.
Features: This comprehensive book includes anything you might ever want to know about protein electrophoresis. Despite it having one-third fewer pages than the previous version, it remains equally (if not more) detailed. This version has seamlessly incorporated technological advances, including capillary electrophoresis, immunosubtraction, and a brief mention of the clinical utility of serum free light chain testing, while retaining historical methods (e.g., Ouchterlonies) for historical continuity. The pictures and images are absolutely gorgeous. The electrophoretic gels are displayed in full color (blue- or purple-stained bands), the nuances of minor restricted bands fully apparent, and spectrophotometric tracings and quantification accompanying the gels. All but the last chapter discuss each of the various topics in great depth. I really appreciate that, in many of the chapters, Dr. Keren includes his opinions ("I would do...") on cases that are not straightforward. This is analogous to "how I would treat..." expert guidance now commonly provided by professional societies. Finally, the last chapter contains 47 case studies — perfect for use with residency or fellowship training.
Assessment: You need this book if you perform protein electrophoresis. Get it.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780340812136
  • Publisher: Taylor & Francis
  • Publication date: 11/20/2003
  • Series: A Hodder Arnold Publication
  • Pages: 422
  • Product dimensions: 7.66 (w) x 9.96 (h) x 0.98 (d)

Meet the Author

University of Michigan Medical School
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Table of Contents

1. Protein Structure and Electrophoresis
2. Techniques for Protein Electrophoresis
3. Immunofixation, Immunosubtraction and Immunoselection Techniques
4. Proteins Identified by Serum Protein Electrophoresis
5. Approach to Pattern Interpretation in Serum
6. Conditions Associated with Monoclonal Gammopathies
7. Examination of Urine for Proteinuria
8. Approach to Pattern Interpretation in Cerebrospinal Fluid (CSF)
9. Laboratory Strategies for Diagnosing Monoclonal Gammopathies
10.Case Studies for Interpretation
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