Protein Engineering and Design / Edition 1

Protein Engineering and Design / Edition 1

by Sheldon J. Park
     
 

ISBN-10: 1420076582

ISBN-13: 9781420076585

Pub. Date: 08/21/2009

Publisher: Taylor & Francis

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein

Overview

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science.

Experimental Protein Engineering

The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering.

Computational Protein Design

The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike.

Product Details

ISBN-13:
9781420076585
Publisher:
Taylor & Francis
Publication date:
08/21/2009
Edition description:
New Edition
Pages:
416
Product dimensions:
6.40(w) x 9.40(h) x 1.00(d)

Table of Contents

Phage Display Systems for Protein Engineering, A. Ernst and S. S. Sidhu

Cell Surface Display Systems for Protein Engineering, S. J. Moore, M. J. Olsen, J. R. Cochran, and F. V. Cochran

Cell-Free Display Systems for Protein Engineering, P. A. Barendt and C. A. Sarkar

Library Construction for Protein Engineering, D. Lipovšek, M. Mena, S. M. Lippow, S. Basu, and B. M. Baynes

Design and Engineering of Synthetic Binding Proteins Using Nonantibody Scaffolds, S. Koide

Combinatorial Enzyme Engineering, P. C. Cirino and C. S. Frei

Engineering of Therapeutic Proteins, F. Wen, S. B. Rubin-Pitel, and H. Zhao

Protein Engineered Biomaterials, C. W. P. Foo and S. C. Heilshorn

Protein Engineering Using Noncanonical Amino Acids, D. Yuksel , D. Pamuk, Y. Ivanova, and K. Kumar

Computer Graphics, Homology Modeling, and Bioinformatics, D. F. Green

Knowledge-Based Protein Design, M. A. Fisher, S. C. Patel, I. Cherny, and M. H. Hecht

Molecular Force Fields, P. Koehl

Rotamer Libraries for Molecular Modeling and Design of Proteins, H. Kono

Search Algorithms, J. M. Shifman and M. Fromer

Modulating Protein Structure, M. S. Hanes, T. M. Handel, and A. B. Chowdry

Modulation of Intrinsic Properties by Computational Design, V. Nanda, F. Xu, and D. Hsieh

Modulating Protein Interactions by Rational and Computational Design, J. S. Marvin and L. L. Looger

Future Challenges of Computational Protein Design, E. J. Choi, G. Guntas, and B. Kuhlman

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