Protein-Lipid Interactions: From Membrane Domains to Cellular Networks / Edition 1

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks / Edition 1

by Lukas K. Tamm
     
 

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant thermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological… See more details below

Overview

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant thermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes.

The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as w2ell as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

Product Details

ISBN-13:
9783527311514
Publisher:
Wiley, John & Sons, Incorporated
Publication date:
10/28/2005
Pages:
470
Product dimensions:
7.00(w) x 9.70(h) x 1.10(d)

Table of Contents

Preface.

List of Contributors.

PART I: HOW LIPIDS SHAPE PROTEINS.

1. Lipid Bilayers, Translocons, and the Shaping of Polypeptide Structure (S. White, et al.).

2. Folding and Stability of Monomeric beta-Barrel Membrane Proteins (J. Kleinschmidt).

3. A Paradigm of Membrane Protein Folding: Principles, Kinetics and Stability of Bacteriorhodopsin Folding (P. Booth).

4. Post-Integration Misassembly of Membrane Proteins and Disease (C. Sanders).

PART II: HOW PROTEINS SHAPE LIPIDS.

5. A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins (M. Wiener).

6. Lipid and Detergent Interactions with Membrane Proteins Derived from Solution Nuclear Magnetic Resonance (A. Arora).

PART III: MEMBRANE PENETRATION BY TOXINS.

7. Lipid Interactions of a-Helical Protein Toxins (G. Anderluh & J. Lakey).

8. Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins (A. Heuck & A. Johnson).

9. Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides (Y. Shai).

PART IV: MECHANISMS OF MEMBRANE FUSION.

10. Cell Fusion in Development and Disease (B. Podbilewicz & L. Chermomodik).

11. Molecular Mechanisms of Intracellular Membrane Fusion (O. Vites & R. Jahn).

12. Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion (A. Lai, et al.).

PART V: CHOLESTEROL, LIPID RAFTS, AND PROTEIN SORTING.

13. Protein-Lipid Interactions in the Formation of Raft Microdomains in Biololgical Membranes (A. Kusumi, et al.).

14. Protein and Lipid Partitioning in Locally Heterogeneous Model Membranes (P. Schwille, et al.).

PART VI: TARGETING OF EXTRINSIC MEMBRANE PROTEIN MODULES TO MEMBRANES AND SIGNAL TRANSDUCTION.

15. In vitro and Cellular Membrane-binding Mechanisms of Membrane-targeting Domains (W. Cho & R. Stahelin).

16. Structure and Interactions of C2 Domains at Membrane Surfaces (D. Cafiso).

17. Structural Mechanisms of Allosteric Regulation by Membrane-binding Domains (B. Canagarajah, et al.).

Subject Index.

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