Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies

Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies

by Robert D. E. Sewell, Claire Simons
     
 

ISBN-10: 0849373107

ISBN-13: 9780849373107

Pub. Date: 12/06/2007

Publisher: Taylor & Francis

Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jabob may be linked to disorders in protein shape referred to as "protein misfolding". Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings

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Overview

Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jabob may be linked to disorders in protein shape referred to as "protein misfolding". Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to potentially more promising treatments.

Product Details

ISBN-13:
9780849373107
Publisher:
Taylor & Francis
Publication date:
12/06/2007
Series:
Enzyme Inhibitors Series
Edition description:
New Edition
Pages:
592
Product dimensions:
6.10(w) x 9.30(h) x 1.20(d)

Table of Contents

Protein Folding and Misfolding, Relevance to Disease and Function Massimi Stefani
Alzheimer’s Disease Charlotte E. Teunissen and Tischa M. van der Cammen
Improving Cholinergic Transmission
Cholinergic Transmission and Acetylcholine release Enhancers Pierre Francotte, Pascal de Tullio and Bernard Pirotte
AChE and its Inhibition Jure Stojan
AChE Inhibitors and their Clinical Assessment Pierre Francotte, Pascal de Tullio and Bernard Pirotte
Reduction in Plaque Formation Christian Czech, Helmut Jacobsen and Celine Adessi
Non-Steroidal Anti-inflammatory Drugs (NSAIDs) Bruno P. Imbimbo and Francesca Speroni
Hydroxy-3-Methyl-Glutaryl-Coenzyme Reductase Inhibitors Dario Cattaneo
Aβ Polymerization Reduction Harry LeVine III and Corrine E. Augelli-Szafran
Carbonic Anhydrase Activators as Potential Anti-Alzheimer’s Disease Agents
Claudiu T. Supuran and Andrea Scozzafava
Detection and Reduction of Neurofibrillary Lesions Jeff Kuret
Protein Misfolding in Alzheimer Disease: Pathogenic or Protective? Rudy J. Castellani, Hyoung-Gon Lee, Akihiko Nunomura, Xiongwei Zhu, Gorge Perry, and Mark A. Smith
Enhancement of Brain Retinoic Acid Levels Ann B. Goodman, Peter McCaffery, Joana A. Palha, Claire Simons and Arthur B. Pardee
Parkinson’s Disease: What is it? What Causes it? And How Can it be Cured? Tom Foltynie, Andrew W. Michell and Roger A. Barker
Restoring Dopamine Levels Nuno Palma, Maria João Bonifácio, Luís Almeida and Patrício Soares-da-Silva
Huntington’s Disease Claire-Anne Gutekunst and Fran Norflus
Amyotrophic Lateral Sclerosis (Motor neuron Disease) Teresa Sanelli, Janice Robertson, Avi Chakabartty and Michael J Strong
Transmissible Spongiform Encephalopathies (TSEs) Michael D. Geschwind and Giuseppe Legname
Overview H. John Smith, Claire Simons and Robert D.E. Sewell

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