Protein Oxidation and Aging

Protein Oxidation and Aging

by Tilman Grune, Betul Catalgol, Tobias Jung, Vladimir Uversky
     
 

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Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat

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Overview

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging.

Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers:

  • Major aspects of the protein oxidation process
  • Cellular mechanisms for managing oxidized proteins
  • Role of protein oxidation in aging
  • Influence of genetic and environmental factors on protein oxidation
  • Measuring protein oxidation in the aging process
  • Protein oxidation in age-related diseases

References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

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Editorial Reviews

From the Publisher
“With its discussion of current concepts linked to protein oxidation and its impact on aging and the pathology of certain age-related diseases, this book is an important contribution to the field. Students, researchers, scientists, and even clinicians will benefit from it.”  (Doody’s, 10 January 2013)

“The format and compartmentalised writing style make this an excellent compendium of knowledge for any researcher interested in assessing our state of knowledge of protein oxidation and ageing. It is easy to find out about the current state of knowledge about a specific reaction, product, method, and/or disease and follow this up by accessing the extensive list of references.”  (Chemistry & Industry, 1 July 2013)

Doody's Review Service
Reviewer: Sophie La Salle, PhD (Midwestern University Chicago College of Osteopathic Medicine)
Description: This volume in the Wiley Series in Protein and Peptide Science reviews our current understanding of the mechanisms leading to formation and removal of oxidized proteins, and explores the role of protein oxidation in aging and the pathology of age-related diseases.
Purpose: Because protein oxidation and accumulation of oxidized proteins have both been linked to the process of aging and the pathology of various human diseases, this book fulfills the important purpose of presenting the current knowledge and the experimental approaches used in the field.
Audience: It is written for graduate students and researchers in cellular and molecular biology, biochemistry, biophysics, genetics, and physiology. Drug design and development specialists as well as those with an interest in the biology of aging also may find this book useful. The authors possess extensive research experience in oxidative stress and antioxidants, neurodegenerative diseases, and proteomics.
Features: The first of the book's four chapters focuses on the mechanistic aspects of protein oxidation; the second chapter deals with strategies employed by cells to ensure removal of oxidized proteins; the third presents the experimental strategies used to investigate the role of protein oxidation in aging; while the final chapter discusses the role of protein oxidation in age-related diseases. The book is both thorough in its selection of content and its coverage of the literature. Interestingly, data from a variety of model organisms are included, which provide a broad perspective of factors impacting protein oxidation in aging. Each chapter ends with an exhaustive list of references to original work and reviews published in the field. A list of abbreviations and a detailed index are also included. Black-and-white figures appear in each chapter, while corresponding color plates are located between chapters 2 and 3 (although these are difficult to find). Because it has only four chapters, this book is information dense. A more dynamic presentation would make it even more valuable to readers.
Assessment: With its discussion of current concepts linked to protein oxidation and its impact on aging and the pathology of certain age-related diseases, this book is an important contribution to the field. Students, researchers, scientists, and even clinicians will benefit from it.

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Product Details

ISBN-13:
9781118493014
Publisher:
Wiley
Publication date:
11/07/2012
Series:
Wiley Series in Protein and Peptide Science , #15
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
516
File size:
3 MB

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